Supplement Tak-653 Raw Powder CAS 1358751-06-0

Product Description

TAK-653 (also known as 9E3TOE5RIZ) is a selective AMPA PAM (Positive Allosteric Modulator) that targets the same pathway as some notable racetams but with higher selectivity and without agonist affinity.

TAK-653, also known as osavampator, is a novel positive allosteric modulator (PAM) of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, currently under development for major depressive disorder (MDD). It enhances synaptic transmission by potentiating glutamate-induced AMPA receptor activity with minimal intrinsic agonist effects, which may contribute to a broader safety margin and reduced seizure risk compared to other AMPA potentiators. Preclinical studies show that TAK-653 activates the mTOR signaling pathway and increases brain-derived neurotrophic factor (BDNF) levels, mechanisms associated with rapid antidepressant effects similar to but without inducing hyperlocomotion, a marker of psychotomimetic side effects. In animal models, it demonstrates cognitive-enhancing properties, improving performance in tasks such as the delayed match-to-sample test. Clinical trials in healthy volunteers indicate that TAK-653 modulates central nervous system function, showing psychostimulant-like effects on neurocognitive tests without significant subjective drug effects1.

Packing&Shipping

FAQ