Elamipretide, SS-31/oxidative stress reduction, energy metabolism improvement

Description

SS-31 (Elamipretide;Elamipretide, MTP-131) is a synthetically produced tetrapeptide compound with CAS Number 736992-21-5, molecular formula C₃₂H₄₉N₉O₅, and molecular weight 639.79. It is currently the most representative “mitochondria-targeted peptide” under investigation, capable of specifically binding to the inner mitochondrial membrane, and serves as a crucial tool molecule in the field of mitochondrial function research. This product is supplied as a high-purity (≥98%, as determined by HPLC) white powder; it is chemically stable and can be used directly in various scientific research experiments.

Key Benefits

The most fundamental characteristic of SS-31 lies in its “mitochondria-targeted” mechanism of action. It binds to cardiolipin on the inner mitochondrial membrane, helping to maintain mitochondrial membrane stability and thereby improving mitochondrial function—enhancing cellular ATP synthesis, optimizing the efficiency of the electron transport chain, and reducing the production of reactive oxygen species (ROS) during oxidative stress. Since mitochondria are central to cellular energy production, this protective effect has drawn significant attention in research on energy metabolism and cell damage.

1. Mitochondrial-targeted binding: It specifically acts on cardiolipin in the inner mitochondrial membrane and is currently one of the most representative mitochondrial-targeted peptides.

2. Energy Metabolism Support: Experimental studies have shown that it enhances cellular ATP synthesis and improves the efficiency of electron transport.

3. Antioxidant Stress Protection: It reduces the formation of reactive oxygen species (ROS) and mitigates oxidative stress-induced cellular damage.

4. Membrane Stability Protection: It helps maintain the structural and functional stability of the mitochondrial inner membrane, thereby protecting overall mitochondrial function.

Applications

SS-31 is primarily used in research related to mitochondrial function, covering multiple levels from cellular experiments to animal models. It is a commonly used tool compound in research areas closely related to mitochondria, such as cardiology, neurology, and metabolism, and is also frequently used as a reference molecule for the development of mitochondria-targeted compounds.

1. Mitochondrial function research: Used in studies of mechanisms such as mitochondrial dynamics, energy metabolism, and oxidative stress.

2. Disease Model Experiments: Suitable for experimental observations in animal models of heart failure, ischemia-reperfusion injury, neurodegenerative diseases, and other conditions.

3. In Vitro Cell Experiments: Used for molecular-level research, such as the assessment of cellular energy metabolism and reactive oxygen species (ROS) levels.

4. Drug Discovery Reference: As a representative molecule of mitochondria-targeted peptides, it is used for structural optimization and lead compound screening of related drugs.