Tirzepatide, LY3298176/insulinotropic polypeptide, metabolic disease research

Product Description

Tirzepatide is a synthetic peptide compound with the development code LY3298176, CAS Number 2023788-19-2, molecular formula C₂₂₅H₃₄₈N₄₈O₆₈, and molecular weight 4813.45. It belongs to a new generation of “dual receptor agonist” peptides capable of simultaneously acting on two key receptors in the human body that are closely related to metabolic regulation, making it a widely used and highly sought-after compound in the field of metabolic research. This product is supplied as a high-purity (≥99%, as determined by HPLC) lyophilized powder. It is stable, easy to store, and convenient for experimental preparation, and can be used directly in various scientific research experiments.

Key Benefits

The most distinctive feature of tirzepatide lies in its “dual-target” mechanism of action. It simultaneously activates the glucose-dependent insulinotropic polypeptide receptor (GIPR) and the glucagon-like peptide-1 receptor (GLP-1R), both of which play crucial roles in appetite regulation, insulin secretion, and energy metabolism. Compared to single-target agonists, this dual-pathway synergistic design is believed to deliver more comprehensive metabolic regulation effects, which is the primary reason for the significant attention it has received in the field of metabolic research. In vitro experiments show that the compound exhibits strong agonist activity for both receptors, and it has also demonstrated clear metabolic regulatory effects in relevant animal models.

1. Synergistic Activation of Two Receptors: Simultaneously activates both the GIPR and GLP-1R receptors to achieve dual-pathway synergistic regulation, which is its core advantage over single-target peptides.

2. Body Weight Regulation: Significant weight loss was observed in relevant animal models.

3. Glucose Metabolism Regulation: Experimental data show that it improves glucose control, providing important reference value for research on glucose metabolism.

4. Prolonged Duration of Action: As a structurally modified long-acting peptide analog, it exhibits a prolonged duration of action, making it suitable for long-term observational studies.

5. High Receptor Affinity: In vitro studies indicate that it possesses strong activation capacity for both target receptors, with sensitive and stable experimental responses.

Applications

Tirzepatide is currently used primarily in scientific research related to metabolic diseases, covering the full spectrum of experimental scenarios from molecular mechanisms to animal models. It serves as a commonly used tool compound in high-priority research areas such as obesity and type 2 diabetes, while also providing an important reference molecule for the development of a new generation of peptide-based metabolic drugs.

1. Research on the mechanisms of metabolic diseases: Used to explore the pathogenesis and intervention targets of diseases such as obesity and type 2 diabetes.

2. In vivo animal experiments: Suitable for subcutaneous administration and long-term efficacy observation in metabolic disease models such as mice and rats.

3. Drug Development Reference: As a representative molecule of dual-receptor agonist peptides, it is used in R&D stages such as structural optimization and lead compound screening for novel metabolic drugs.

4. In Vitro Cellular and Molecular Experiments: Can be used for molecular-level experiments such as receptor agonist activity evaluation and downstream signaling pathway studies.

5. Standard Reference Material: Can serve as a standard reference material for the development of relevant peptide detection methods and quality analysis.