Mazdutide CAS 77614-16-5 99% Purity 5mg 10mg Vials Door To Door Service

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Email：Demi@hzzmtrade.com

Sales Manager:Demi

• Mazdutide is an innovative therapeutic agent with the following details:
  English name: Mazdutide

  CAS number: 2259884-03-0

  Mazdutide is a GLP-1R/GCGR dual receptor agonist developed by Innovent Biologics, intended for the long-term weight management of adult patients with obesity or overweight.
  Mechanism of Action
  Mazdutide innovatively adopts a dual receptor agonist mechanism. On one hand, it activates GLP-1R to promote insulin secretion, suppress appetite, and delay gastric emptying, thereby reducing food intake. On the other hand, it activates GCGR to promote fat oxidation and energy expenditure. This two-pronged approach enhances the ability to reduce weight and regulate metabolism.
  Weight Loss Efficacy
  In the Phase II clinical trial of Mazdutide, patients in the 3mg, 4.5mg, and 6mg Mazdutide groups (administered once weekly) achieved an average weight reduction of 7.2%, 10.6%, and 11.6% respectively after 24 weeks of treatment. Results from the Phase III GLORY-1 trial showed that during the 48-week treatment period, the 6mg Mazdutide group had an average weight loss of 14.01%, while the placebo group only had a weight loss of 0.30%.
  Improvement of Metabolic Indicators
  Mazdutide not only effectively reduces weight but also comprehensively improves metabolic indicators. For example, in the Phase III clinical trial, the 6mg Mazdutide group saw an average reduction of 8.56mmHg in systolic blood pressure, a decrease of 0.65mmol/L in triglycerides, and a significant reduction in uric acid levels. Additionally, it showed a significant improvement effect on fatty liver, which can effectively reduce the pressure on the cardiovascular system and lower the risk of obesity-related complications.
  Target Population
  It is suitable for patients with simple obesity (BMI ≥ 28) and patients with a BMI of ≥ 24 who have one or more comorbidities, such as hyperglycemia, hypertension, dyslipidemia, fatty liver, and obstructive sleep apnea.

Mazdutide (brand name: Xinelem) is a global first and the first to be approved for market use, a dual receptor for glucagon (GCG) and glucagon-like peptide-1 (GLP-1), belonging to a long-acting synthetic gastrin-releasing peptide (OXM) analog.
Core efficacy
1. Significant weight loss effect
In overweight/obese adults, a 6 mg dose treatment for 48 weeks resulted in an average weight loss of 14.01%, and some patients achieved a maximum reduction of 21% (high dose 16 mg, in clinical trial stage)
The proportion of patients with weight loss ≥ 5%: 82.8% in the 6 mg group (vs 11.5% in placebo)
The average reduction in waist circumference: 10.96 cm (6 mg group)
2. Improved blood glucose control (applicable to type 2 diabetes)
After 24 weeks of treatment, glycated hemoglobin (HbA1c) decreased by 2.15% (6 mg group), superior to placebo (-0.14%) and dulaglutide
In patients with type 2 diabetes combined with obesity, 48% of patients achieved the dual goals of HbA1c < 7.0% and weight loss ≥ 10%, significantly better than semaglutide (21%)
3. Improved liver fat metabolism
For patients with baseline liver fat content ≥ 10%, liver fat content decreased by 80.2% after 48 weeks of treatment
Significantly increased the proportion of liver fat returning to normal (< 5%)
Multiple metabolic benefits
Blood pressure: Systolic blood pressure decreased by approximately 6.75 mmHg
Blood lipids: Triglycerides ↓ 0.52 mmol/L, total cholesterol ↓ 0.45 mmol/L, LDL-C ↓ 0.31 mmol/L

Packing
Product Specifications
5mg/vial,10vials/box
10mg/vial,10vials/box
15mg/vial,10vials/box
20mg/vial,10vials/box
30mg/vial,10vials/box
40mg/vial,10vials/box
50mg/vial,10vials/box
60mg/vial,10vials/box

Our company is located in Hangzhou and is a company specializing in the research, production and development of peptide products. Founded in recent years, the company is committed to applying advanced biotechnology to the health industry to meet the market demand for high-quality and high-efficiency peptide products.

We have an experienced professional team that is dedicated to providing innovative solutions and excellent customer service. We work closely with our clients, relying on advanced production facilities and strict quality control systems, to ensure that our products meet the highest safety and purity standards.

Over the years, we have continuously supplied new products to markets such as Europe, America, Australia, Japan and Southeast Asia. We have always adhered to the corporate principle of "quality and reputation first", and through years of continuous development, we have gained a good reputation in the fitness industry.

We provide customers with first-class products, competitive prices and top-notch services to meet the individual needs of each customer.
We have collaborated with numerous leading logistics companies worldwide, and with a wide global transportation network, we ensure that our safe and efficient logistics services can meet your urgent needs. We look forward to establishing a long-term business partnership with you on the basis of equality and mutual benefit.

Q1. How do you ensure product quality?

A1. We have a strict quality management system in place. All batches must pass tests and meet our
standards before being released into the warehouse.

Q2: Why should you buy from us instead of other suppliers?

A2: Because we are a factory, we can provide lower prices and guaranteed quality. We have extensiveexperience in domestic and foreign trade and provide services in an honest, timely and efficient manner.

Q3: How to place an order for each product?

A3: Please send us an inquiry and let us know your requirements; we will send you a complete quotation
including freight, confirm the order and send payment/deposit, we willarrange production or delivery of
the goods after receiving the bank receipt.

Q4: Do you have stock?

A4: We understand most customers prefer stock, so we'll try to keep stock for most products. However,
for some rare products, we won't keep stock and it needs time to synthesize.

Q5: What's your MOQ?

A5: For this product, 10vials/box (5mg/10mg/15mg/20mg/30mg/vial), minimum order is 1 boxes.

Q6: Is there a discount?

A6: Different quantity has different discount, for larger quantity, we alway support with better price.

.Q7:How to make an order?

A7:Please send us a message and inform us of your required products and quantity. Then we will calculate the quotation for you promptly.

Q8:Can we do printing or labeling on the bottles?

A8:Yes, you can. We offer various printing methods, such as screen printing, hot stamping and label printing.

Q9:What is the normal lead time?

A9:For in-stock products, we will ship them within 24-48 hours after receiving your payment. For small-batch customized color bottles, the delivery time is 3-15 days.