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Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > Retatrutide for Sale > China Factory Retatrutide CAS 2381089-83-2 99% Purity GLP-1 Peptide Lyophilized Powder Research Use
China Factory Retatrutide CAS 2381089-83-2 99% Purity GLP-1 Peptide Lyophilized Powder Research Use buy - large image1
China Factory Retatrutide CAS 2381089-83-2 99% Purity GLP-1 Peptide Lyophilized Powder Research Use buy - image1
China Factory Retatrutide CAS 2381089-83-2 99% Purity GLP-1 Peptide Lyophilized Powder Research Use buy - image2
China Factory Retatrutide CAS 2381089-83-2 99% Purity GLP-1 Peptide Lyophilized Powder Research Use buy - image3
China Factory Retatrutide CAS 2381089-83-2 99% Purity GLP-1 Peptide Lyophilized Powder Research Use buy - image4
China Factory Retatrutide CAS 2381089-83-2 99% Purity GLP-1 Peptide Lyophilized Powder Research Use buy - image5
China Factory Retatrutide CAS 2381089-83-2 99% Purity GLP-1 Peptide Lyophilized Powder Research Use buy - image6

China Factory Retatrutide CAS 2381089-83-2 99% Purity GLP-1 Peptide Lyophilized Powder Research Use

7023 Inquiries

Unit Price:

$60-70/MT FOB

Get Latest Price
CAS No.:

2381089-83-2

Grade:

Pharmaceutical Grade

Content:

99%

Port:

gz

Packaging:

10mg 20mg ,10vials/box

Price valid (until):

2027-12-31

Company Type:
Trader
Location:
China
Qualification:
Main Products:

Retatrutide,Tirzepatide,GHK-Cu,TB500,Nad+

  • Product Description

  • Seller Information

  • Inquiry History

  • Description


    Description  


    Sales manager:Nora
    whatsapp:+12817797656
    Email:lisa@qtsbio.com


    Product Name Retatrutide
    Appearance White powder
    CAS No. 2381089-83-2
    Application Weight Loss


       Product Function


    Retatrutide (LY3437943) acetate is a triple agonist peptide for the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R).

    Retatrutide acetate inhibits human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643, and 0.775 nM, respectively. It exhibits activity on mouse GCGR, GIPR, and GLP-1R with EC50 values of 2.32, 0.191, and 0.794 nM, respectively.

    In vivo, Retatrutide (LY3437943) acetate engages with GCGR and enhances glucose tolerance in an ipGTT by acting through GIP or GLP-1 receptors. Activation via the glucagon receptor by Retatrutide acetate leads to significant weight reduction and increased energy expenditure. Retatrutide acetate can be utilized in research related to obesity.

    Retatrutide, LY3437943

    CAS#: 2381089-83-2

    Molecular Formula: C221H342N46O68

    Molecular Weight: 4731.33

    Sequence: H-Tyr-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-α-Me-Leu-Leu-Asp-Lys-{diacid-C20-gamma-Glu-(AEEA)-Lys}-Ala-Gln-Aib-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2

    Appearance: White Powder

    Purity (HPLC): ≥99.0%

    Single Impurity (HPLC): ≤1.0%

    Sodium Content (HPLC): 5.0%-12.0%

    Moisture Content (Karl Fischer): ≤10.0%

    Peptide Content: ≥80.0%

    Storage: Store at 2-8 degrees Celsius in a dry and cool place.

    Packaging: 1g-1kg, plastic bottle

    Intended Use: For scientific research purposes

    .

    Scientific research shows that Reta can effectively regulate appetite, reduce food intake, promote body metabolism, accelerate fat burning, and achieve significant weight loss effects.

    Clinical data show that within the prescribed course of treatment, users experience a significant average weight loss, with sustained good results.

    Shop China Factory Retatrutide CAS 2381089-83-2 99% Purity GLP-1 Peptide Lyophilized Powder Research Use-Detailed Image 1  Shop China Factory Retatrutide CAS 2381089-83-2 99% Purity GLP-1 Peptide Lyophilized Powder Research Use-Detailed Image 2


    Product Application


      • Mechanism of Action and Molecular Structure of Retatrutide:

        Triple Agonist Design
        - GLP-1 receptor: Retatrutide delays gastric emptying, suppress appetite, and promote insulin secretion.
        - GIP receptor: Retatrutide enhances insulin sensitivity and regulate central satiety signals.
        - Glucagon receptor (GCGR): Retatrutide activates liver energy metabolism, promote lipolysis and glycogenolysis, and increase basal metabolic rate.
        The triple synergistic effect increases energy consumption while reducing energy intake, significantly improving weight loss effects.

        Indications and Efficacy:

        ★ Obesity Treatment:
        In the Phase II clinical trial, patients in the highest dose group (12 mg) lost an average of 24.2% weight after 48 weeks, and some patients lost more than 30%.

        ★ Metabolic Dysfunction-Associated Fatty Liver Disease (MASLD):
        Retatrutide can reduce liver fat content by 86%, and more than 85% of patients achieve regression of liver steatosis.

        ★ Type 2 Diabetes:
        Significantly reduce glycated hemoglobin (HbA1c) and improve blood sugar control.

        ★ Potential Cardiovascular Benefits:
        Animal studies have shown that it may indirectly protect cardiovascular health by improving blood pressure and heart function, but further clinical verification is needed.


    FAQ

    1. How to make an order?
    Send me message and let me know what you need with quantity , then i will calculate to you

    2. What's the lead time and shipping ways?
    We will delivery to the package by UPS, FEDEX, DHL paket and YANWEN express to you after receive your payment, it would take around 5-15 days to your address.

    3. How do i keep the peptides when i receive it ?
    Peptides in the form of lyophilized powder can be transported at room temperature by vacuum packaging, while polypeptides in the dissolved state need to be refrigerated at 2°C - 8°C. For long-term storage, peptides should be stored in the form of lyophilized powder store at -20°C or -80°C in a sealed container with desiccant, which can avoid the degradation of peptides to the greatest extent.

    4. What's the payment methods?
    We could accept pay through Wise, Bank Transfer, Alipay USDT and BTC.



       Why choose us?   


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    Shop China Factory Retatrutide CAS 2381089-83-2 99% Purity GLP-1 Peptide Lyophilized Powder Research Use-Detailed Image 6
    ECHEMI Editorial Reference
    Retatrutide is a novel triple agonist peptide of the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR) and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide inhibits human GCGR, GIPR and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively and mouse GCGR, GIPR, and GLP-1R with EC50 values of 2.32, 0.191 and 0.794 nM, respectively. It is an important tool for obesity research.Retatrutide potently activates the GLP-1R signaling pathway to stimulate glucose-dependent insulin secretion through activity at the GIP receptor (GIPR) or the GLP-1R.Retatrutide is a synthetic peptide with glucose-lowering effects. It is an antidiabetic agent against type 2 diabetes (T2D), stimulating insulin and suppressing glucagon secretion in a glucose-dependent manner.Retatrutide was also shown to delay gastric emptying, lower fasting and postprandial glucose concentration, decrease food intake and reduce body weight in patients with type 2 diabetes.
    Retatrutide (LY-3437943) was discovered by the American pharmaceutical company Eli Lilly and Company. It is a triple glucagon hormone receptor agonist (GLP-1, GIP, and GCGR receptors) for obesity. The 2024 Lasker~DeBakey Clinical Medical Research Award has been given to Joel Habener and Svetlana Mojsov for their discovery of a new hormone GLP-1(7-37) and to Lotte Knudsen for her role in developing sustained acting versions of this hormone as a treatment for obesity.

    Basic Info
    Product Name:

    Retatrutide

    Other Name:

    Retatrutide;GIPR/GLP-1R;LY3437943Retatrutide;Retalutide;Retatrutide (sodium salt);Retatrutide RT5;retatrutide 5mg;Retatratide

    CAS No.:

    2381089-83-2

    InChIKeys:

    MLOLQJNKXBNWFW-SAGGEDDASA-N

    Molecular Weight:

    0

    EC Number:

    200-001-8

    Color/Form:

    White lyophilized

    Characteristics
    Water Solubility:

    Soluble in water (5mg/ml).

    Storage Conditions:

    -20°C

    Critical Temperature & Pressure:

    -20°C

    Research
    Class:

    Triple agonist — GCGR, GIPR, GLP-1R

    Status:

    Investigational (Phase 3)

    Mechanism:

    Simultaneously activates glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Engineered from the native GIP backbone with amino acid substitutions to confer GCGR and GLP-1R activity.

    EC50 (Human GCGR):

    5.79 nM

    EC50 (Mouse GIPR):

    0.191 nM

    EC50 (Mouse GLP1R):

    0.794 nM

    EC50 (Mouse GCGR):

    2.32 nM

    EC50 (Human GLP1R):

    0.775 nM

    EC50 (Human GIPR):

    0.0643 nM

    Source:

    Jastreboff AM, et al. N Engl J Med. 2023;389(6):514-526.DOI

    Clinical Development:

    NCT04881760; NCT05882045; NCT06354660

    References
    ChEMBL:

    CHEMBL5095485

    DrugBank:

    DB18993

    KEGG DRUG:

    D12430

    PubChem:

    PubChem

    Disclaimer:

    Retatrutide is an investigational compound not yet approved by FDA or EMA. This listing is for industrial and laboratory research use only. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Retatrutide,Tirzepatide,GHK-Cu,TB500,Nad+

    Location:

    Beijing

    Year of Establishment:

    2026

  • Inquiry History
    7023 Inquiries
    Country Product Purchase Quantity Date Posted
    United States

    Retatrutide 2381089-83-2

    3 MT Mar 28, 2026
    United Kingdom

    Retatrutide - 2381089-83-2

    1 G Feb 10, 2026
    United States

    Retatrutide CAS 2381089-83-2 10mg vial

    20 MT Mar 7, 2026
    United States

    Factory Retatrutide API 99% Purity CAS 2381089-83-2

    5 KG Nov 10, 2025
    United Kingdom

    Peptide powder Retatrutide 99% pure for Body building cas 2381089-83-2 Weight Loss Peptide with COA

    1 MT Mar 22, 2026
    United States

    2381089-83-2

    100 G Jul 14, 2026
    United States

    2381089-83-2

    100 G Feb 24, 2026
    United States

    2381089-83-2

    100 MT Dec 9, 2023
    United States

    Retatrutide 2381089-83-2

    200 MG May 16, 2026
    United Kingdom

    2381089-83-2 retatrutide

    300 MG Feb 13, 2026
    United States

    Retatrutide 2381089-83-2 wholesale

    500 MT Nov 3, 2023
    United States

    Retatrutide CAS 2381089-83-2 99%

    10 PCS Feb 21, 2026
    Poland

    CAS 2381089-83-2 (Custom Peptide)

    40 MT Apr 10, 2026
    Austria

    Peptide Retatruide CAS 2381089-83-2

    100 MT Apr 4, 2026
    Austria

    Retatrutide CAS 2381089-83-2 10mg vial

    20 PCS Feb 10, 2026
    United States

    GLP-1 / GIP Retatrutide cas 2381089-83-2

    1 MT Oct 16, 2024
    United States

    Retatrutide 99% High Quality CAS 2381089-83-2

    1 G Jan 23, 2026
    United States

    Injection Peptide Tirzepatide/Retatrutide/ Semaglutide Peptides CAS 2381089-83-2

    10  Oct 21, 2023
    Australia

    GMP Grade 99% Retatrutide Lyophilized Powder CAS 2381089-83-2

    10 G Jun 12, 2026
    Palestine

    Factory 99% Purity Retatrutide Peptide CAS 2381089-83-2 Door-To-Door Service

    10 MG Mar 16, 2026
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