Retatrutide,reta

Retatrutide is a triple agonist of GLP-1/GIP/ glucagon receptor, which can simultaneously improve blood sugar control, suppress appetite and promote weight loss. The pharmacological mechanism of action: Retatrutide exerts its effects through triple receptor activation: • GLP-1 receptor activation: It enhances insulin secretion, inhibits glucagon release, delays gastric emptying, and increases satiety, thereby lowering blood sugar and reducing food intake. • GIP receptor activation: It enhances insulin secretion when blood sugar rises, regulates lipid metabolism, and reduces food intake. At the same time, it can stimulate the release of glucagon when blood sugar is low, helping to maintain stable blood sugar levels. • Glucagon receptor (GCGR) activation: Increases energy expenditure, promotes lipolysis, reduces fat production, and enhances insulin secretion under the balance of GLP-1 and GIP. The synergy of the three can produce a superimposed effect at multiple levels, including central appetite regulation, peripheral energy expenditure, and liver glycolipid metabolism, thereby achieving blood sugar control and significant weight loss.

Clinical effect

• Blood glucose control: In patients with type 2 diabetes, Retatrutide can significantly reduce glycated hemoglobin (HbA1c) and improve blood glucose homeostasis .

• Weight management: Clinical trials have shown that after 68 weeks of Retatrutide at a dose of 12 mg, the average weight loss of obese patients was approximately 28.7%, among which 39.4% of the patients lost more than 30% and 23.7% lost more than 35%. In the interim trial of type 2 diabetes patients, the average weight loss was 17.5% at 24 weeks and 24.2% at 48 weeks.

• Comprehensive metabolic improvement: It may have a positive regulatory effect on metabolic indicators such as blood lipids and blood pressure, reducing the risk of cardiovascular diseases

The applicable population mainly targets patients with type 2 diabetes complicated with obesity or overweight, as well as patients with simple obesity (BMI≥30 or ≥27 with complications). . Some studies have also explored its potential in metabolism-related diseases such as non-alcoholic fatty liver disease (NAFLD).

Shanghai TL-output Peptide Technology Co., Ltd China and is recognized as a high-tech enterprise providing technical consulting and testing services for novel chemical compounds.


The company’s internal quality control standards consistently exceed national regulatory requirements, and a comprehensive quality assurance system has been firmly established. Over 60% of our products are exported overseas, with primary markets including Europe, the Americas, Australia, Russia, Japan, South Korea, as well as various countries and regions across Southeast Asia.

The company maintains a 1,000-square-meter R&D and pilot-scale production facility, equipped with a wide array of modern laboratory research instruments. This facility enables us to conduct small-scale research and pilot production for a diverse range of chemical compounds. Furthermore, the company operates a collaborative production base spanning 30 *mu* (approximately 2 hectares), outfitted with a complete suite of large-scale stainless steel and glass-lined production equipment. With reactor capacities ranging from 50 to 2,000 liters, the facility possesses the capability to handle R&D and production at the ton scale.

Shanghai TL-output Peptide Technology Co., Ltd. is supported by a highly organized team, experienced technical personnel, and expert chemists specializing in R&D and quality control—assets that enable us to consistently deliver high-quality products. We collaborate with numerous renowned domestic and international scientific research institutions, providing professional services and superior products; our custom synthesis services, in particular, have earned us an excellent reputation within the industry.


Upholding the core philosophy of "Green and Healthy," Shanghai TL-output Peptide Technology Co., Ltd. sincerely looks forward to strengthening exchanges and cooperation with partners and friends both at home and abroad.

Q
How does your factory control quality
A
All the raw material purchasing and production quality control are strictly following the ISO9001: 2008 management system. Besides, the full-featured detection equipment and GMP quality management system to provide the strongest guarantee for high quality product.
Q
What’s your main markets
A
We accept FOB, CIF, etc. You can choose the one which is the most convenient or cost effective for you. We have multiple global routes and support door-to-door dedicated transportation services. The sample within 3 days, and bulk order within 5 days.
Q
What’s your main markets
A
North America, Europe, Asia, etc.
Q
What is your package
A
Usually glass bottle, supports customized packaging specifications