Metyrapone1 54-36-4
TDS 7 Inquiries
54-36-4
Pharmaceutical Grade
99.99%
shanghai
Orient
Vial/Bottle/Bag/Carton
Yes
2029-12-31
pharmaceutical intermediates,peptides,electronic chemicals
-
Product Details
-
Seller Information
-
Inquiry History
-
DescriptionECHEMI Editorial ReferenceMetyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1.Target: CYP11B1Metyrapone is a drug used in the diagnosis of adrenal insufficiency and occasionally in the treatment of Cushing's syndrome (hypercortisolism). Metyrapone blocks cortisol synthesis by reversibly inhibiting steroid 11β-hydroxylase. This stimulates ACTH secretion, which in turn increases plasma 11-Deoxycortisol levels.
Solid
Metyrapone is an aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency. It has a role as a diagnostic agent, an antimetabolite and an EC 1.14.15.4 (steroid 11beta-monooxygenase) inhibitor.|An inhibitor of the enzyme steroid 11-beta-monooxygenase. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of cushing syndrome.|Metyrapone is an Adrenal Steroid Synthesis Inhibitor. The mechanism of action of metyrapone is as an Adrenal Steroid Synthesis Inhibitor.|Metyrapone is a pyridine derivative and a glucocorticoid synthesis inhibitor. Metyrapone inhibits 11-beta-hydroxylase, thereby inhibiting synthesis of cortisol from 11-deoxycortisol and corticosterone from desoxycorticosterone in the adrenal gland. Removal of the negative feedback mechanism exerted by cortisol results in increased adrenocorticotropic hormone (ACTH) secretion by the pituitary gland. In turn, continuing stimulation of adrenal gland by ACTH results in accumulation of corticoid precursors, 11-desoxycortisol and desoxycorticosterone. These metabolites are excreted in urine that maybe used as indicators for pituitary responsiveness.|An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.CertificatesBasic Info-
Product Name:
Metyrapone
Other Name:1-Propanone,2-methyl-1,2-di-3-pyridinyl-;1-Propanone,2-methyl-1,2-di-3-pyridyl-;2-Methyl-1,2-di-3-pyridinyl-1-propanone;1,2-Bis(3-pyridyl)-2-methyl-1-propanone;Mepyrapone;Methapyrapone;Methopirapone;Methopyrapone;Methopyrinine;2-Methyl-1,2-bis(3-pyridyl)-1-propanone;2-Methyl-1,2-di(β-pyridyl)-1-propanone;2-Methyl-1,2-di-3-pyridyl-1-propanone;Metopirone;Metopyrone;Metyrapone;Su 4885;Metopiron;Metyrapon;Methopyrone;Methbipyranone;Metroprione;NSC 25265;37245-80-0
CAS No.:54-36-4
Molecular Formula:C14H14N2O
InChIKeys:InChIKey=FJLBFSROUSIWMA-UHFFFAOYSA-N
Molecular Weight:226.27
Exact Mass:226.27
EC Number:200-206-2
UNII:ZS9KD92H6V
NSC Number:760076|25265
DSSTox ID:DTXSID1023314
NCI Thesaurus Code:C47619
Color/Form:CRYSTALS FROM ETHER & PENTANE|WHITE TO LIGHT AMBER, FINE CRYSTALLINE POWDER
ATC Code:V - Various
HScode:2933399090
Categories:
Characteristics-
PSA:
42.8
XLogP3:2
Appearance:Solid
Density:1.1±0.1 g/cm3
Melting Point:50-51 °C
Boiling Point:384.4°C at 760 mmHg
Flash Point:>230 °F
Refractive Index:1.565
Water Solubility:Sparingly soluble with water.
Storage Conditions:Store at +4°C
Odor:CHARACTERISTIC ODOR
Experimental Properties:FORMS WATER-SOLUBLE SALTS WITH ACIDS
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Skin irritation, Category 2
Eye irritation, Category 2
Specific target organ toxicity â single exposure, Category 3
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
Storage P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
-
-
Seller Information
-
Business Type:
Trader
-
Main Products:
pharmaceutical intermediates,peptides,electronic chemicals
-
Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone
-
Payment Terms:
100% TT in advance
-
Average lead Time:
10 days
-
Total Annual Revenue:
$10 million-$25 million
-
Total Employees:
51-100
-
Year of Establishment:
2024
-
-
Inquiry History7 Inquiries
Country Product Purchase Quantity Date Posted 
United Kingdom
Metyrapone
50 G Sep 21, 2026 
Botswana
metyrapone
500 G Jul 3, 2026 
Canada
Metyrapone
100 G Mar 28, 2026
United Kingdom
Metyrapone
2 MT Mar 14, 2026 
United States
Metyrapone Powder
1 KG Nov 11, 2024 
Saudi Arabia
Metyrapone
1 KG Oct 20, 2024 
India
Metyrapone
1 KG Jul 20, 2024 Post an enquiry for this product
More from this Seller
-
-
![Linear Alkyl Benzene Sulphonic Acid (Labsa)-- 27176-87-0]( "Linear Alkyl Benzene Sulphonic Acid (Labsa)-- 27176-87-0")
-
Linear Alkyl Benzene Sulphonic Acid (Labsa)-- 27176-87-0
Pharmaceutical Grade / 99.99%
-
-
-
![HMG peptide]( "HMG peptide")
-
HMG peptide
Industrail Grade / 99%
$33-34/UNIT FOB
-
-
-
![n-Butane | Pharmaceutical Grade | CAS 106-97-8| 99.99% Purity | 10mg 20mg 30mg Vials]( "n-Butane | Pharmaceutical Grade | CAS 106-97-8| 99.99% Purity | 10mg 20mg 30mg Vials")
-
n-Butane | Pharmaceutical Grade | CAS 106-97-8| 99.99% Purity | 10mg 20mg 30mg Vials
Pharmaceutical Grade / 99.99%
-
-
-
![2-PROPENYLTRIMETHYLSILANE 18163-07-0]( "2-PROPENYLTRIMETHYLSILANE 18163-07-0")
-
2-PROPENYLTRIMETHYLSILANE 18163-07-0
Industrial Grade / 99%
-
-
-
![Bromoethane 99% Min CAS 74-96-4 Ethyl Bromide Organic Synthesis Intermediate Bulk Supply]( "Bromoethane 99% Min CAS 74-96-4 Ethyl Bromide Organic Synthesis Intermediate Bulk Supply")
-
Bromoethane 99% Min CAS 74-96-4 Ethyl Bromide Organic Synthesis Intermediate Bulk Supply
Industrial Grade / 99.99%
-
-
-
![Triethylenetetramine CAS:112-24-3]( "Triethylenetetramine CAS:112-24-3")
-
Triethylenetetramine CAS:112-24-3
Industrial Grade / 99%
$23-25/MT FOB
-
