Dihexa DI10 Factory direct delivery price advantage and quality advantage
Pharmaceutical Grade
99%
SH
JL
box
Yes
2028-12-31
Peptide
-
Product Description
-
Seller Information
-
DescriptionBasic Info
-
Product Name:
Dihexa DI10
Categories:
Research-
Class:
Angiotensin IV-derived oligopeptide / HGF-c-Met potentiator
Status:Research compound — Not FDA approved
Mechanism:A synthetic, orally active, blood-brain-barrier-permeable oligopeptide (Hexanoyl-Tyr-Ile-Ahx-NH₂) derived from angiotensin IV. Dihexa binds hepatocyte growth factor (HGF) with high affinity (Kd = 65 pM) and allosterically potentiates HGF activity at its receptor c-Met, promoting dendritic spinogenesis and synaptogenesis. In preclinical models it was reported to be seven orders of magnitude more potent than BDNF at promoting synapse formation. Note: the foundational 2014 paper (McCoy AT, et al. Neurobiol Learn Mem. 2014) was retracted in 2025.
EC50 (HGF Binding KD):65 pM
Activity note:Dihexa is an HGF potentiator, not a direct receptor agonist. It does not activate c-Met alone but markedly augments HGF-induced c-Met activation at low nanomolar HGF concentrations. Functional synaptogenic activity was reported at 10⁻¹°–10⁻⁻ M (original data now subject to retraction).
Source:Original report: McCoy AT, et al. Neurobiol Learn Mem. 2014;115:112-120 (retracted 2025). Benoist CC, et al. J Pharmacol Exp Ther. 2014;351(3):628-637.
Clinical Development:
References-
PubChem:UNII:Literature:
Benoist CC, et al. J Pharmacol Exp Ther. 2014 — HGF/c-Met mechanism; McCoy AT, et al. Neurobiol Learn Mem. 2014 — Synaptogenesis data (Retracted 2025); Athira Pharma: Fosgonimeton (prodrug) pipeline status
Disclaimer:Dihexa is NOT FDA-approved or EMA-approved as a medicine. It is a research compound only. The foundational 2014 paper describing its synaptogenic potency was retracted in 2025. Its phosphate prodrug fosgonimeton failed a Phase 2/3 Alzheimer’s trial (LIFT-AD, 2024). This listing is for industrial and laboratory research use only. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
-
-
Seller Information
-
Business Type:
Trader
-
Main Products:
Peptide
-
Location:
zhejiangshengjinhuashiyiwushijiangdongjiedaodongnanlu656hao
-
Average lead Time:
15 days
-
Total Annual Revenue:
$1 million-$2.5 million
-
Total Employees:
5-10
-
Year of Establishment:
2026
-
-
Country Product Purchase Quantity Date Posted Post an enquiry for this product
More from this Seller
-
-
-
Fast Delivery Semaglutide Gip GLP-1 Low Price CAS 910463-68-2
Pharmaceutical Grade / 99%
$33-36/UNIT FOB
-
-
-
-
Teriparatide A pureza atinge mais de 99%, e todos os produtos foram testados.
Pharmaceutical Grade / 99%
$33-36/UNIT FOB
-
-
-
-
Wolverine BC+TB500 WS10 CAS 885340-08-9 99% Purity TB-500 Thymosin B4 Acetate 4mg 10mg 20mg
Pharmaceutical Grade / 99%
$33-36/UNIT FOB
-
-
-
-
Factory Direct Supply Vilon Bulk Peptide Supplier Peptide Raw Material|Fats Shipping Manufacturer
Pharmaceutical Grade / 99%
$33-36/UNIT FOB
-
-
-
-
Freeze Dried Whole Sale Price Livagen 5mg Customized LI20 Safe Shipping
Pharmaceutical Grade / 99%
$33-36/UNIT FOB
-
-
-
-
KissPeptin-10 KS5 KS10 374675-21-5 Factory direct delivery price advantage and quality advantage
Pharmaceutical Grade / 99%
$1/UNIT FOB
-