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Home > Biochemical Engineering > Plant Extracts > Cytisine for Sale > Cytisine, Cytisinicline, Baphitoxine/nicotine-like, smoking-cessation direction, respiratory stimulant
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Cytisine, Cytisinicline, Baphitoxine/nicotine-like, smoking-cessation direction, respiratory stimulant

1 Inquiries

Unit Price:

$100-130/G FOB

Get Latest Price
CAS No.:

485-35-8

Grade:

Pharmaceutical Grade

Content:

99%

Port:

qingdao

Brand:

sinov

Packaging:

vial/box

Price valid (until):

2026-10-22

Company Type:
Trader
Location:
Hongkong, China
Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
Average Lead Time:
7 days
Qualification:
Main Products:

Weight Loss Peptide,Reta,Tirz,Sema,5 Amino 1mq,Cosmetic raw material,API,SLU-PP-332

  • Product Description

  • Seller Information

  • Inquiry History

  • Description


      Product Detail  


    Description

    This product is cytisine, also known as sophorine, with the CAS number 485-35-8. It is a natural bioactive alkaloid extracted and refined from the seeds of leguminous plants such as Sophora alopecuroides, Cytisus scoparius and Wisteria sinensis. Its molecular formula is C₁₁H₁₄N₂O and molecular weight is approximately 190.24. It normally appears as white to yellow crystalline powder with a purity of over 98% (tested by HPLC). As a well-established commercial pharmaceutical raw material, this product can be supplied in different grades including pharmaceutical grade and reagent grade according to application requirements. It is mainly provided to pharmaceutical manufacturers, scientific research institutions and testing organizations. It is an alkaloid variety with a long application history and definite research value. The product shall be stored in a sealed, light-proof and low-temperature environment.

    Key Effects

    Cytisine has a unique mode of action: it targets a specific type of receptor in the human nervous system — the nicotinic acetylcholine receptor, which is also where nicotine exerts its effects. Cytisine binds to this receptor and produces similar but not identical effects. Therefore, it can reduce cravings for nicotine and withdrawal symptoms to a certain extent. This is the core principle behind its development as a smoking cessation drug, and related smoking cessation preparations have been used as medicines in some countries. In addition, in traditional medical applications, cytisine was once used as a respiratory stimulant to rescue respiratory arrest caused by surgery, trauma and other conditions. It is also an important tool compound in neuropharmacology research.

    Its specific functions can be summarized as follows:
    Smoking cessation research support: Acts on nicotinic receptors to help reduce nicotine cravings and withdrawal symptoms;
    Relief of nicotine addiction symptoms: Serves as a partial agonist of nicotinic receptors for research related to nicotine dependence;
    Respiratory stimulant effect: Traditionally used as first aid support for conditions such as reflex respiratory arrest;
    Neuropharmacological research: Used as an experimental tool compound to study nicotinic receptor functions and addiction mechanisms;
    Quality control of traditional Chinese medicine: Acts as a standard reference substance for content determination of relevant medicinal materials and preparations.

    Applications

    This product is a natural alkaloid pharmaceutical raw material, mainly targeted at the fields of smoking cessation drug research and development, neuropharmacological research and pharmaceutical production, and it also has stable applications in the field of traditional Chinese medicine detection.
    Its main application areas can be summarized as follows:
    Smoking cessation drug research and development: Used as an active pharmaceutical ingredient and research compound for smoking cessation medicines (such as relevant tablets);
    Neuropharmacological research: Serves as a tool substance for neuroscience research on nicotinic receptors, nicotine addiction mechanisms and other related topics;
    Pharmaceutical production field: Applied in the raw material supply of relevant alkaloid medicines;
    Traditional Chinese medicine research and detection: Used as a quality control standard substance and reference substance for medicinal materials such as Sophora alopecuroides;
    Scientific research reagent supply: Provided to universities, research institutes and pharmaceutical enterprise laboratories as experimental materials for natural product research;
    Export trade and raw material supply: Supplied as an alkaloid raw material to pharmaceutical companies, scientific research institutions and traders, with specifications available upon customer requirements.

    Shop Cytisine, Cytisinicline, Baphitoxine/nicotine-like, smoking-cessation direction, respiratory stimulant-Detailed Image 1 Shop Cytisine, Cytisinicline, Baphitoxine/nicotine-like, smoking-cessation direction, respiratory stimulant-Detailed Image 2 Shop Cytisine, Cytisinicline, Baphitoxine/nicotine-like, smoking-cessation direction, respiratory stimulant-Detailed Image 3 Shop Cytisine, Cytisinicline, Baphitoxine/nicotine-like, smoking-cessation direction, respiratory stimulant-Detailed Image 4 Shop Cytisine, Cytisinicline, Baphitoxine/nicotine-like, smoking-cessation direction, respiratory stimulant-Detailed Image 5


    Items Specifications
    CYTISINE 10mg
    CYTISINE 1g
    CYTISINE 1kg
    ECHEMI Editorial Reference
    Cytisine is an alkaloid that occurs naturally in several plant genera, such as Laburnum and Cytisus. Cytisine is a partial agonist of α4β2 nAChRs[1], and partial to full agonist at β4 containing receptors and α7 receptors[2]. has been used medically to help with smoking cessation[3].
    Cytisine is an organic heterotricyclic compound that is the toxic principle in Laburnum seeds and is found in many members of the Fabaceae (legume, pea or bean) family. An acetylcholine agonist, it is widely used throughout Eastern Europe as an aid to giving up smoking. It has a role as a nicotinic acetylcholine receptor agonist, a phytotoxin and a plant metabolite. It is an alkaloid, an organic heterotricyclic compound, a secondary amino compound, a lactam and a bridged compound.|Cytisine is an alkaloid naturally derived from the Fabaceae family of plants including the genera Laburnum and Cytisus. Recent studies have shown it to be a more effective and significantly more affordable smoking cessation treatment than nicotine replacement therapy. Also known as baptitoxine or sophorine, cytisine has been used as a smoking cessation treatment since 1964, and is relatively unknown in regions outside of central and Eastern Europe. Cytisine is a partial nicotinic acetylcholine agonist with a half-life of 4.8 hours. Recent Phase III clinical trials using Tabex (a brand of Cytisine marketed by Sopharma AD) have shown similar efficacy to varenicline, but at a fraction of the cost.

    Basic Info
    Product Name:

    Cytisine

    Other Name:

    1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one,1,2,3,4,5,6-hexahydro-,(1R,5S)-;Cytisine;1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one,1,2,3,4,5,6-hexahydro-,(1R)-;(1R,5S)-1,2,3,4,5,6-Hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one;Baptitoxin;Baptitoxine;Cytiton;Cytitone;Sophorine;Ulexine;Tabex;Ulexin;Laburnin;Sophorin;(-)-Cytisine;Cytisin;Tsitafat;Cytisinicline;3728-36-7;1267572-93-9;1932311-41-5;1933793-08-8;2308481-87-8

    CAS No.:

    485-35-8

    Molecular Formula:

    C11H14N2O

    InChIKeys:

    InChIKey=ANJTVLIZGCUXLD-UHFFFAOYSA-N

    Molecular Weight:

    190.24

    Exact Mass:

    190.24

    EC Number:

    207-616-0

    UNII:

    53S5U404NU

    NSC Number:

    407282

    Color/Form:

    Orthorhombic prisms from acetone|Solid

    ATC Code:

    N - Nervous system

    HScode:

    2933990090

    Categories:

    Plant Extracts

    Characteristics
    PSA:

    32.3

    XLogP3:

    0.2

    Appearance:

    light yellow powder

    Density:

    1.2±0.1 g/cm3

    Melting Point:

    152-153 °C

    Boiling Point:

    218 °C @ Press: 2 Torr

    Flash Point:

    203.6±25.7 °C

    Refractive Index:

    1.623

    Water Solubility:

    439g/L(16 ºC)

    Storage Conditions:

    Store at RT

    Vapor Pressure:

    7.61X10-6 mm Hg at 25 deg C (est)

    Toxicity:

    LD50 in mice (mg/kg): 1.73 i.v.; 9.4 i.p.; 101 orally (Barlow, McLeod)

    Specific rotation:

    D17 -120°

    Henrys Law Constant:

    Henry's Law constant = 4.01X10-12 atm-cu m/mol at 25 °C (est)

    Dissociation Constants:

    pK1 = 6.11; pK2 = 13.08

    Collision Cross Section:

    137.9 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

    Experimental Properties:

    Deliquescent crystals, soluble in water and alchol. pH of 0.1 molar aqueous solution = 4.3 /Cytisine hydrochloride/|Hydroxyl radical reaction rate constant = 8.59X10-11 cu cm/molec-sec at 25 °C (est)

    Hazard Identification

    Classification of the substance or mixture

    Acute toxicity - Category 3, Oral

    Skin irritation, Category 2

    Eye irritation, Category 2

    Specific target organ toxicity – single exposure, Category 3

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H301 Toxic if swallowed

    H315 Causes skin irritation

    H319 Causes serious eye irritation

    H335 May cause respiratory irritation

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

    P271 Use only outdoors or in a well-ventilated area.

    Response

    P301+P316 IF SWALLOWED: Get emergency medical help immediately.

    P321 Specific treatment (see ... on this label).

    P330 Rinse mouth.

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P332+P317 If skin irritation occurs: Get medical help.

    P362+P364 Take off contaminated clothing and wash it before reuse.

    P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

    P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

    P319 Get medical help if you feel unwell.

    Storage

    P405 Store locked up.

    P403+P233 Store in a well-ventilated place. Keep container tightly closed.

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    In original packages, in dry, and light-protected premises at temperature of 15 deg C to 25 deg C (60 - 75 deg F)

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Weight Loss Peptide,Reta,Tirz,Sema,5 Amino 1mq,Cosmetic raw material,API,SLU-PP-332

    Location:

    Unit D01,3/F., Wong King Industrial Building,No.2 Tai Yau Street, Kowloon

    Payment Terms:

    TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    7 days

    Total Annual Revenue:

    $50 million-$100 million

    Total Employees:

    51-100

    Year of Establishment:

    2012

    We have more than 10 years experience in the pharmacy filed. Mainly manufactures pharmaceutical APIs,Pharmaceutical intermediate and Cosmetic raw material. Owing to the good quality and competitive price, we have a very good reputation in China's pharmaceutical circles.

    In the principle of "Quality Oriented", Jianfeng passed the certification of ISO9001:2008 Quality Management System.

    Our products are based on bulk, high volume, wholesale price, third party testing, certificate reporting, and bring high quality ingredients to many domestic and overseas enterprises.

    "Honesty, practicality, innovation, development" are our values. Jianfeng would like to cooperate with you with high quality products and competitive price.

  • Inquiry History
    1 Inquiries
    Country Product Purchase Quantity Date Posted
    United States

    Cytisine

    5  Feb 1, 2024
    Post an enquiry for this product
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