High Purity Clobetasol propionate CAS 25122-46-7 >98% For Pharmaceutical Intermediate Research
3 Inquiries
25122-46-7
Chemicals
99%
Qingdao
Guozhao
25kg/drum
Yes
2026-11-22
CHEMICALS
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Product Details
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceClobetasol propionate is a anti-inflammatory corticosteroid used to treat various skin disorders.Target: Glucocorticoid ReceptorClobetasol propionate is a corticosteroid of the glucocorticoid class used to treat various skin disorders including eczema and psoriasis. It is also highly effective for contact dermatitis caused by exposure to poison ivy/oak. Clobetasol belongs to US Class I (Europe: class IV) of the corticosteroids, making it one of the most potent available. It comes in sham
Clobetasol propionate is the 17-O-propionate ester of clobetasol. A potent corticosteroid, it is used to treat various skin disorders, including exzema and psoriasis. It has a role as an anti-inflammatory drug. It is an 11beta-hydroxy steroid, a 20-oxo steroid, a glucocorticoid, a fluorinated steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a chlorinated steroid. It derives from a clobetasol and a propionic acid.|Clobetasol propionate is a prednisolone derivative with higher specificity for glucocorticoid receptors than mineralocorticoid receptors. It has demonstrated superior activity compared to [fluocinonide] and was first described in the literature in 1974. Clobetasol Propionate was granted FDA approval on 27 December 1985.|Clobetasol Propionate is the propionate salt form of clobetasol, a topical synthetic corticosteroid with anti-inflammatory, anti-pruritic, and vasoconstrictive properties. Clobetasol propionate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. This results in synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators. Specifically, clobetasol propionate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from membrane phospholipids by phospholipase A2.|A derivative of PREDNISOLONE with high glucocorticoid activity and low mineralocorticoid activity. Absorbed through the skin faster than FLUOCINONIDE, it is used topically in treatment of PSORIASIS but may cause marked adrenocortical suppression.Research & Reference NoteHigh Purity Clobetasol propionate CAS 25122-46-7 >98% For Pharmaceutical Intermediate Research is listed on ECHEMI for industrial / laboratory sourcing. This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
Authoritative sourcesDisclaimer: This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
Reviewed by ECHEMI Scientific Review - Platform editorial review for research chemicals
Basic Info-
Product Name:
Clobetasol propionate
Other Name:Pregna-1,4-diene-3,20-dione,21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-,(11β,16β)-;Pregna-1,4-diene-3,20-dione,21-chloro-9-fluoro-11β,17-dihydroxy-16β-methyl-,17-propionate;(11β,16β)-21-Chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione;21-Chloro-21-deoxybetamethasone 17-propionate;Dermovate;Clobetasol propionate;Clobetasol 17-propionate;CGP 9555;Clobesol;Temovate;Clobederm;GR 2/925;Dermoxin;Dermoxinale;Dermoval;CCl 4725;Karison;Clobex;Olux;Skin Cap;Olux-E;Tenovate
CAS No.:25122-46-7
Molecular Formula:C25H32ClFO5
InChIKeys:InChIKey=CBGUOGMQLZIXBE-XGQKBEPLSA-N
Molecular Weight:466.97000
Exact Mass:466.97
EC Number:246-634-3
UNII:779619577M
DSSTox ID:DTXSID6045907
NCI Thesaurus Code:C28934
HScode:2937290090
Categories:
Characteristics-
PSA:
80.67000
XLogP3:4.10310
Appearance:White Crystalline Powder
Density:1.28 g/cm3
Melting Point:195.5-197 °C
Boiling Point:569ºC at 760 mmHg
Flash Point:297.9ºC
Refractive Index:1.56
Vapor Pressure:2.58E-15mmHg at 25°C
Collision Cross Section:205.1 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Hazard IdentificationClassification of the substance or mixture
Reproductive toxicity, Category 1B
Specific target organ toxicity â repeated exposure, Category 2
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 4
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H360 May damage fertility or the unborn child
H373 May cause damage to organs through prolonged or repeated exposure
H413 May cause long lasting harmful effects to aquatic life
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
Response P318 IF exposed or concerned, get medical advice.
P319 Get medical help if you feel unwell.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Distributor
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Main Products:
CHEMICALS
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Location:
No. 109, Chailu Street, Qingnian Park Subdistrict, Huaian District, Jinan City, Shandong Province 280
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Year of Establishment:
2026
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Inquiry History3 Inquiries
Country Product Purchase Quantity Date Posted 
Trinidad and Tobago
Clobetasol propionate 99% white powder 25122-46-7 Senwayer
1 KG Dec 4, 2023 
Pakistan
Clobetasol Propionate
2 KG Dec 17, 2025 
United States
Clobetasol propionate
5 G Sep 2, 2025 Post an enquiry for this product
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