Product Overview

1-Acetylimidazole is an N-acyl imidazole, a member of the azole family in which an acetyl group is bonded to the ring nitrogen of imidazole. It is supplied as a white to off-white crystalline solid and is widely used as a mild and selective acyl transfer reagent. Because the imidazole ring acts as a good leaving group, the compound transfers its acetyl unit under gentle conditions, which makes it valuable in pharmaceutical synthesis, protein chemistry and fine organic synthesis.

Key Attributes

Key Highlights

• HIGH PURITY: 98.0% min assay by HPLC, with low impurity profile suitable for synthetic and analytical work.
• MILD AND SELECTIVE ACYLATION: Transfers its acetyl group under gentle conditions, allowing selective acylation where harsher acid chlorides or anhydrides are unsuitable.
• PROVEN IN PROTEIN CHEMISTRY: A classical reagent for the modification of histidine and tyrosine residues in proteins and peptides at near-neutral pH.
• VERSATILE SYNTHETIC BUILDING BLOCK: Serves as an imidazole-containing intermediate for pharmaceutical, agrochemical and fine chemical programs.
• FLEXIBLE ORDER SIZE: Minimum order quantity of 1 kg, with packaging available in 1 kg bottles and 5 kg, 10 kg and 25 kg drums.
• RELIABLE LEAD TIME: Orders are normally shipped within 2 weeks, by air or by sea according to quantity and destination.
• FULL DOCUMENTATION: Certificate of Analysis and technical documents are provided with every shipment.

Product Description

1-Acetylimidazole, also referred to as N-acetylimidazole, is the N-acetyl derivative of imidazole with the molecular formula C5H6N2O and a molecular weight of 110.11. Dideu Group supplies this product as a white to off-white crystalline solid with an assay of 98.0% min, packed to protect it from moisture during storage and transport.

The chemical value of the compound lies in its activated amide structure. Bonding the acetyl group to the imidazole nitrogen weakens the C-N acyl bond and makes imidazole an efficient leaving group, so the acetyl unit is transferred to nucleophiles such as alcohols, amines, thiols and phenols under mild conditions. This reactivity pattern is the reason N-acyl imidazoles are described in the literature as mild acylating agents, and it gives chemists a practical alternative when acid chlorides are too aggressive or when selectivity between two functional groups must be controlled. The compound also functions as a model system in mechanistic studies of acyl-enzyme intermediates.

Because the material hydrolyzes on contact with water, it is packed in sealed inner liners and should be handled in a dry environment and resealed after each use. The crystalline form and melting behavior are consistent from batch to batch, which supports reliable weighing and dosing in both laboratory and production settings.

Dideu Group offers 1-Acetylimidazole with a minimum order quantity of 1 kg and packaging in 1 kg bottles and 5 kg, 10 kg and 25 kg drums. Standard lead time is within 2 weeks from order confirmation, and shipments are arranged by air or by sea. Every batch is released with a Certificate of Analysis and supporting technical documents.

Applications

Pharmaceutical Synthesis

Used as an acetylating agent and heterocyclic building block in the preparation of active pharmaceutical ingredients and their intermediates. Its mild reactivity is particularly useful in multi-step routes where sensitive functional groups must remain intact, and published process patents describe N-acetylimidazole as the acetylating reagent of choice for selective acylation steps in steroidal drug intermediates.

Protein and Peptide Chemistry

A classical reagent for the selective chemical modification of amino acid side chains. It reacts with histidine residues under mild conditions and is also used for tyrosine modification, making it a standard tool for structure-activity studies, enzyme active-site investigation and receptor-binding research.

Bioanalytical and Structural Biology Research

N-acyl imidazole chemistry is applied in nucleic acid research, including RNA structural probing and reversible functionalization of ribose hydroxyl groups. Isotopically labeled derivatives have been used to introduce reporter nuclei for protein NMR studies.

Analytical Chemistry

Employed as an acylation derivatizing reagent for chromatographic analysis, improving the volatility and detection of target analytes in gas chromatography workflows.

Fine Organic Synthesis

Serves as an acyl transfer reagent and imidazole source in the synthesis of heterocyclic compounds, acyl thioesters, metal complexes and specialty intermediates for research and custom manufacturing programs.

Biomass and Polymer Modification

Used in the acylation of biopolymers, including lignin functionalization and surface modification of cellulose-based materials, where it enables esterification under conditions compatible with sensitive natural substrates.

Specifications

Batch-specific values are stated on the Certificate of Analysis issued with each shipment.

Packaging and Shipping

Storage Recommendations

• Store in a cool, dry and well-ventilated place.
• Keep containers tightly sealed and reseal immediately after each use.
• Protect from moisture and high humidity.
• Protect from direct sunlight and heat sources.

Minimum order quantity is 1 kg. Standard lead time is within 2 weeks from order confirmation. Goods are shipped by air or by sea depending on order quantity and destination, and export documentation is prepared in advance to support smooth customs clearance.

Company Profile

Dideu Group is a professional supplier of fine chemicals and specialty chemicals based in China, serving customers in global markets with a full range of products from laboratory-scale reagents to industrial quantities. Our portfolio covers pharmaceutical intermediates, heterocyclic building blocks, acylation and derivatization reagents, inorganic salts and specialty organic chemicals.

Every product we supply is released against defined specifications, and our quality team issues a Certificate of Analysis with each batch so that customers can verify identity, assay and impurity levels before use. We work with research institutes, contract manufacturers and industrial users, and we support both single-shipment orders and repeat supply programs.

Our sales and technical staff respond to enquiries with substance-specific information rather than generic catalogues, helping customers confirm suitability, packaging format and delivery schedule early in the sourcing process. Reliability, documentation quality and consistent batch-to-batch performance are the basis on which we build long-term partnerships.

FAQ

1. What is the minimum order quantity for 1-Acetylimidazole?

The minimum order quantity is 1 kg, supplied in a sealed 1 kg bottle. Larger quantities are packed in 5 kg, 10 kg or 25 kg fibre drums.

2. What is the lead time?

Standard lead time is within 2 weeks from order confirmation. For larger industrial volumes, Dideu will confirm the exact schedule at the quotation stage.

3. What packaging options do you offer?

We offer 500 g and 1 kg in sealed bottles with moisture-proof liners, and 5 kg, 10 kg and 25 kg in fibre drums with inner liners. All packaging is sealed against moisture to protect the product during storage and transport.

4. What payment terms do you accept?

We accept T/T and L/C. The specific terms are agreed during contract negotiation according to order value and customer preference.

5. Do you provide COA and technical documents?

Yes. Dideu provides a Certificate of Analysis with every batch, along with the technical documents required for import and internal quality review.

6. How do you ship the goods?

Shipments are arranged by air or by sea depending on quantity and destination. Air freight is normally used for laboratory-scale and urgent orders, while sea freight is more economical for industrial volumes.

7. How should the product be stored after delivery?

Store in a cool, dry and well-ventilated place with the container tightly sealed. The material hydrolyzes on contact with water, so it should be handled in a dry environment and resealed promptly after each use.