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Brefeldin A High Purity Natural Product CAS 20350-15-6 Research Grade Reagent for Cell Biology and Pharmaceutical Research

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CAS No.:

20350-15-6

Grade:

Reagent Grade

Content:

99%

Port:

qingdao

Brand:

Packaging:

1g/vial, 5g/vial, 25g/vial, 100g/vial

Sample Available:

Yes

Price valid (until):

2026-10-26

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Jinan topfull chemical co.,ltd

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

7 days

Qualification:

Main Products:

Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

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Product Details
Seller Information

Description

—— Product Specifications ——

Shop Brefeldin A High Purity Natural Product CAS 20350-15-6 Research Grade Reagent for Cell Biology and Pharmaceutical Research-Detailed Image 1

—— Product Detail ——

- - - - Product Overview
        
        Brefeldin A (BFA) is a naturally occurring macrolide antibiotic with the molecular formula C₁₆H₂₄O₄ and molecular weight of 280.36 g/mol. This white to off-white crystalline powder is a valuable research reagent in cell biology and pharmaceutical research. Brefeldin A is produced by various fungi and is widely used as a protein transport inhibitor in cell biology studies.
        
        Synthetic Process
        
        Fermentation: Brefeldin A is produced by fermentation of fungi such as Eupenicillium brefeldianum
        
        Extraction: The compound is extracted from the fermentation broth using organic solvents
        
        Purification: The crude extract is purified by chromatography and recrystallization
        
        Drying: The purified product is dried under vacuum
        
        Mechanism of Action
        
        Protein Transport Inhibition: Blocks the transport of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus by inhibiting the ADP-ribosylation factor 1 (ARF1) guanine nucleotide exchange factor
        
        Golgi Disruption: Causes rapid disassembly of the Golgi apparatus and redistribution of Golgi proteins to the ER
        
        Autophagy Modulation: Affects autophagic flux and lysosomal function
        
        Antiviral Activity: Exhibits antiviral properties by interfering with viral protein trafficking
        
        Research Applications & Market Significance
        
        Cell Biology: Essential tool for studying protein transport and organelle dynamics
        
        Antiviral Research: Investigated as a potential antiviral agent
        
        Cancer Research: Studied for its effects on cell cycle progression and apoptosis
        
        Immunology: Used in studies of immune cell function and cytokine secretion
        
        Drug Discovery: Serves as a tool compound for target validation studies
        
        Quality Specifications
        
        Purity: ≥98.0% determined by HPLC
        
        Melting point: 204-206°C
        
        Loss on drying: ≤1.0%
        
        Residue on ignition: ≤0.1%
        
        Storage: -20°C, sealed, protected from light
        
        Stable for 24 months when properly stored
        
        Packaging & Shipping
        
        Research quantities: 5mg, 10mg amber glass vials
        
        Bulk quantities: 25mg, 100mg amber glass vials
        
        Shipped with cool packs for temperature-sensitive orders
        
        International shipping available with proper documentation

— C ompany Profile ——

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

—— Q&A ——

Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

Q4: What is your MOQ? Is there a discount?
A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.

Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.

ECHEMI Editorial Reference

Brefeldin A is a specific inhibitor of protein trafficking which blocks the protein transport from the endoplasmic reticulum to the Golgi complex.
A fungal metabolite which is a macrocyclic lactone exhibiting a wide range of antibiotic activity.

Certificates

Basic Info

Product Name:

Brefeldin A

Other Name:

4H-Cyclopent[f]oxacyclotridecin-4-one,1,6,7,8,9,11a,12,13,14,14a-decahydro-1,13-dihydroxy-6-methyl-,(1R,2E,6S,10E,11aS,13S,14aR)-;4H-Cyclopent[f]oxacyclotridecin-4-one,1,6,7,8,9,11aβ,12,13,14,14aα-decahydro-1β,13α-dihydroxy-6β-methyl-;4H-Cyclopent[f]oxacyclotridecin-4-one,1,6,7,8,9,11a,12,13,14,14a-decahydro-1,13-dihydroxy-6-methyl-,[1R-(1R*,2E,6S*,10E,11aS*,13S*,14aR*)]-;(1R,2E,6S,10E,11aS,13S,14aR)-1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one;Brefeldin A;Ascotoxin;Cyanein;Decumbin;Cyanaein;Nectrolide;Synergisidin;(+)-Brefeldin A;Brefeldin;NSC 107456;NSC 244390;NSC 56310;NSC 89671;3459-16-3;11006-23-8;11039-44-4;19022-59-4;27740-36-9;31874-13-2;60132-23-2;78206-62-9

CAS No.:

20350-15-6

Molecular Formula:

C16H24O4

InChIKeys:

InChIKey=KQNZDYYTLMIZCT-KQPMLPITSA-N

Molecular Weight:

280.36

Exact Mass:

280.36

EC Number:

247-104-4

HScode:

29411090

Categories:

Alkaloids

Characteristics

PSA:

66.8

XLogP3:

1.96240

Appearance:

White to almost white Crystalline Powder

Density:

1.1±0.1 g/cm3

Melting Point:

190 °C

Boiling Point:

492.675°C at 760 mmHg

Flash Point:

87 °C

Refractive Index:

1.513

Water Solubility:

soluble in dimethylsulfoxide, dichloromethane and ethanol. Slightly soluble in water.methanol: 10 mg/mL, clear, colorless to faintly yellow

Storage Conditions:

2-8°C

Vapor Pressure:

0.56 hPa ( 20 °C)

Toxicity:

LD50 i.p. in mice: >200 mg/kg (Haerri)

Specific rotation:

93 º (C=2 IN MEOH)

See More Brefeldin A Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Brefeldin A Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

Location:
RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA

Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
7 days

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
11-50

Year of Establishment:
2022

Jinan Topfull Chemical Co., Ltd. is a global chemical Industrial and focuses on advanced chemical technology. Specialized in Cosmetic materials, water treatment, fine chemicals and so on. We are looking forward to working together with the people of all circles at home and abroad to seek common development!
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Brefeldin A High Purity Natural Product CAS 20350-15-6 Research Grade Reagent for Cell Biology and Pharmaceutical Research

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