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Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > vericiguat for Sale > Vericiguat CAS 1350653-20-1 99% Purity Soluble Guanylate Cyclase Stimulator API Intermediate for Heart Failure Research fk
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Vericiguat CAS 1350653-20-1 99% Purity Soluble Guanylate Cyclase Stimulator API Intermediate for Heart Failure Research fk

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Unit Price:

$100-130/G FOB

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CAS No.:

1350653-20-1

Grade:

Reagent Grade

Content:

99%

Port:

qingdao

Brand:

//

Packaging:

10mg, 25mg, 50mg, 100mg, 1g

Sample Available:

Yes

Price valid (until):

2026-10-26

Company Type:
Trader
Location:
China
Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance
Average Lead Time:
7 days
Qualification:
Main Products:

Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

  • Product Description

  • Seller Information

  • Description

    —— Product Specification ——

    Parameter Specification Details
    Product Name Vericiguat BAY1021189; MK-1242
    CAS Number 1350653-20-1 —
    Molecular Formula C₁₉H₁₆F₂N₈O₂ 19 carbons, 16 hydrogens, 2 fluorines, 8 nitrogens, 2 oxygens
    Molecular Weight 426.39 g/mol —
    Appearance White to off-white crystalline powder Visual inspection
    Purity ≥99.0% Determined by HPLC
    Storage 0-8°C, sealed, protected from light Refrigerator
    Packaging 1g, 5g, 10g, 25g, 100g Amber glass vials/bottles
    Application Research use only Soluble guanylate cyclase stimulator studies


    —— Product Detail ——

    Product Overview

    Vericiguat (CAS 1350653-20-1), also known as BAY1021189 or MK-1242, is an orally active soluble guanylate cyclase (sGC) stimulator with the molecular formula C₁₉H₁₆F₂N₈O₂ and a molecular weight of 426.39 g/mol . The compound is chemically designated as methyl (4,6-diamino-2-(5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate . It features a pyrazolo[3,4-b]pyridine core substituted with a 2-fluorobenzyl group and a 4,6-diamino-pyrimidinyl carbamate moiety . Vericiguat is developed for the treatment of chronic heart failure, specifically for patients with worsening heart failure and reduced ejection fraction



    Packaging & Shipping

      • Research quantities: 10mg, 25mg, 50mg amber glass vials

      • Bulk quantities: 100mg, 1g, 5g amber glass bottles

      • Custom packaging available upon request

      • Not classified as hazardous material for transport under normal conditions

      • Product for research and analytical use only; not for human or veterinary use

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    — Company profile ——


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    Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

    Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

    We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

    To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

    Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

     

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    —— Q&A ——

    Q1: How to confirm the product quality before placing orders?
    A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

    Q2: Can you supply free samples?
    A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

    Q3: How do you treat quality complaints?
    A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

    Q4: What is your MOQ? Is there a discount?
    A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
    Q: Is there a discount?
    A: Yes, for larger quantities, we always support with better prices.

    Q5: How to start orders or make payments?
    A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.



    ECHEMI Editorial Reference
    Vericiguat is a novel oral soluble guanylate cyclase (sGC) stimulator.- Soluble guanylate cyclase (sGC) is an enzyme that is activated by nitric oxide (NO). The activation initiates a signaling cascade which converts guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP). cGMP levels increase & protein kinase G (PKG) is activated, resulting in a decrease of intracellular free Ca++ -> vascular smooth muscle cell relaxation.- However, individuals with HF have reduced NO levels. Vericiguat, as a sGC stimulator, increases the enzymatic activity of sGC to generate cGMP independently of NO and enhances sGC sensitivity to endogenous NO.Vericiguat is the 2nd drug in this class and follows riociguat ADEMPAS, which has been approved for treating pulmonary arterial hypertension.SOCRATES-REDUCED was a phase II dose-finding trial of vericiguat in HF-rEF. The primary endpoint, change in NTproBNP over 12 weeks, was not statistically significant compared to placebo. A secondary exploratory analysis suggested a dose-response relationship in which higher doses of vericiguat were associated with greater reductions in NTproBNP levels.
    ChEBI: Vericiguat is a pyrazolopyridine that is 5-fluoro-1H-pyrazolo[3,4-b]pyridine in which the amino hydrogen at position 1 has been substituted by a 2-fluorobenzyl group and the hydrogen at position 3 has been substituted by a 4,6-diamino-5-[(methoxycarbonyl)amino]pyrimidin-2-yl group. It is a soluble guanylate cyclase stimulator which is used for treatment of chronic heart failure. It has a role as a soluble guanylate cyclase activator, a vasodilator agent and an antihypertensive agent. It is an aminopyrimidine, a pyrazolopyridine, a carbamate ester and an organofluorine compound.
    Research & Reference Note

    Vericiguat CAS 1350653-20-1 99% Purity Soluble Guanylate Cyclase Stimulator API Intermediate for Heart Failure Research fk is listed on ECHEMI for industrial / laboratory sourcing. This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

    Disclaimer: This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

    Reviewed by ECHEMI Scientific Review - Platform editorial review for research chemicals

    Certificates
    • Vericiguat CAS 1350653-20-1 99% Purity Soluble Guanylate Cyclase Stimulator API Intermediate for Heart Failure Research fk Certificates 1 TDS

    Basic Info
    Product Name:

    vericiguat

    Other Name:

    vericiguat;BAY1021189;Carbamic acid, N-[4,6-diamino-2-[5-fluoro-1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-, methyl ester;Vericiguat (BAY 1021189);MK-1242;methyl (4,6-diamino-2-(5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate (Vericiguat);Inhibitor,BAY-1021189,BAY 1021189,inhibit,Guanylate Cyclase,Vericiguat;Vericygua

    CAS No.:

    1350653-20-1

    Molecular Formula:

    C19H16F2N8O2

    InChIKeys:

    QZFHIXARHDBPBY-UHFFFAOYSA-N

    Molecular Weight:

    426.38

    Exact Mass:

    426.38

    Color/Form:

    Light yellow to brown

    Characteristics
    Density:

    1.63±0.1 g/cm3(Predicted)

    Boiling Point:

    535.9±50.0 °C(Predicted)

    PKA:

    10.61±0.70(Predicted)

    Critical Temperature & Pressure:

    Store at 0-8 °C

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

    Location:

    RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA

    Payment Terms:

    TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    7 days

    Total Annual Revenue:

    $1 million-$2.5 million

    Total Employees:

    11-50

    Year of Establishment:

    2022

    Jinan Topfull Chemical Co., Ltd. is a global chemical Industrial and focuses on advanced chemical technology. Specialized in Cosmetic materials, water treatment, fine chemicals and so on. We are looking forward to working together with the people of all circles at home and abroad to seek common development!
  • Country Product Purchase Quantity Date Posted
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