Vericiguat CAS 1350653-20-1 99% Purity Soluble Guanylate Cyclase Stimulator API Intermediate for Heart Failure Research fk
TDS
1350653-20-1
Reagent Grade
99%
qingdao
//
10mg, 25mg, 50mg, 100mg, 1g
Yes
2026-10-26
Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceVericiguat is a novel oral soluble guanylate cyclase (sGC) stimulator.- Soluble guanylate cyclase (sGC) is an enzyme that is activated by nitric oxide (NO). The activation initiates a signaling cascade which converts guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP). cGMP levels increase & protein kinase G (PKG) is activated, resulting in a decrease of intracellular free Ca++ -> vascular smooth muscle cell relaxation.- However, individuals with HF have reduced NO levels. Vericiguat, as a sGC stimulator, increases the enzymatic activity of sGC to generate cGMP independently of NO and enhances sGC sensitivity to endogenous NO.Vericiguat is the 2nd drug in this class and follows riociguat ADEMPAS, which has been approved for treating pulmonary arterial hypertension.SOCRATES-REDUCED was a phase II dose-finding trial of vericiguat in HF-rEF. The primary endpoint, change in NTproBNP over 12 weeks, was not statistically significant compared to placebo. A secondary exploratory analysis suggested a dose-response relationship in which higher doses of vericiguat were associated with greater reductions in NTproBNP levels.
ChEBI: Vericiguat is a pyrazolopyridine that is 5-fluoro-1H-pyrazolo[3,4-b]pyridine in which the amino hydrogen at position 1 has been substituted by a 2-fluorobenzyl group and the hydrogen at position 3 has been substituted by a 4,6-diamino-5-[(methoxycarbonyl)amino]pyrimidin-2-yl group. It is a soluble guanylate cyclase stimulator which is used for treatment of chronic heart failure. It has a role as a soluble guanylate cyclase activator, a vasodilator agent and an antihypertensive agent. It is an aminopyrimidine, a pyrazolopyridine, a carbamate ester and an organofluorine compound.Research & Reference NoteVericiguat CAS 1350653-20-1 99% Purity Soluble Guanylate Cyclase Stimulator API Intermediate for Heart Failure Research fk is listed on ECHEMI for industrial / laboratory sourcing. This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
Authoritative sourcesDisclaimer: This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
Reviewed by ECHEMI Scientific Review - Platform editorial review for research chemicals
Certificates-
TDS
Basic Info-
Product Name:
vericiguat
Other Name:vericiguat;BAY1021189;Carbamic acid, N-[4,6-diamino-2-[5-fluoro-1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-, methyl ester;Vericiguat (BAY 1021189);MK-1242;methyl (4,6-diamino-2-(5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate (Vericiguat);Inhibitor,BAY-1021189,BAY 1021189,inhibit,Guanylate Cyclase,Vericiguat;Vericygua
CAS No.:1350653-20-1
Molecular Formula:C19H16F2N8O2
InChIKeys:QZFHIXARHDBPBY-UHFFFAOYSA-N
Molecular Weight:426.38
Exact Mass:426.38
Color/Form:Light yellow to brown
Categories:
Characteristics-
Density:
1.63±0.1 g/cm3(Predicted)
Boiling Point:535.9±50.0 °C(Predicted)
PKA:10.61±0.70(Predicted)
Critical Temperature & Pressure:Store at 0-8 °C
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Seller Information
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Business Type:
Trader
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Main Products:
Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524
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Location:
RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA
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Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
7 days
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Total Annual Revenue:
$1 million-$2.5 million
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Total Employees:
11-50
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Year of Establishment:
2022
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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