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Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > AHU-377 for Sale > Sacubitril CAS 149709-62-6 98% Purity API Intermediate for Heart Failure Research
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Sacubitril CAS 149709-62-6 98% Purity API Intermediate for Heart Failure Research

TDS

Unit Price:

$100-130/G FOB

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CAS No.:

149709-62-6

Grade:

Reagent Grade

Content:

99%

Port:

qingdao

Brand:

//

Packaging:

10mg, 25mg, 50mg, 100mg, 1g

Sample Available:

Yes

Price valid (until):

2026-10-26

Company Type:
Trader
Location:
China
Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance
Average Lead Time:
7 days
Qualification:
Main Products:

Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

  • Product Description

  • Seller Information

  • Description

    —— Product Specification ——

    Parameter Specification Details
    Product Name Sacubitril AHU-377; LCZ696 intermediate
    CAS Number 149709-62-6 —
    Molecular Formula C₂₄H₂₉NO₅ 24 carbons, 29 hydrogens, 1 nitrogen, 5 oxygens
    Molecular Weight 411.49 g/mol —
    Appearance Colorless to pale yellow oil Low melting solid at 20°C
    Purity ≥98.0% Determined by HPLC
    Density 1.151±0.06 g/cm³ (Predicted) —
    pKa 4.72±0.10 (Predicted) —
    Storage -20°C, sealed, protected from light Long-term storage
    Packaging 1g, 5g, 10g, 25g, 100g Amber glass vials/bottles
    Application Research use only //


    —— Product Detail ——

    Product Overview

    Tenofovir alafenamide fumarate (CAS 1392275-56-7), also known as TAF, GS-7340 hemifumarate, or Vemlidy, is an orally bioavailable phosphonoamidate prodrug of the antiviral agent tenofovir . It is a hemifumarate salt form with the molecular formula C₂₁H₂₉N₆O₅P · ½ C₄H₄O₄ and a molecular weight of 534.5 g/mol . The compound is a nucleotide reverse transcriptase inhibitor (NRTI) developed by Gilead Sciences for the treatment of chronic hepatitis B virus (HBV) infection and HIV infection . Compared to tenofovir disoproxil fumarate (TDF), TAF achieves similar antiviral efficacy at less than one-tenth the dose, with improved plasma stability and better delivery of tenofovir to hepatocytes, resulting in improved renal and bone safety profiles



    Packaging & Shipping

      • Research quantities: 10mg, 25mg, 50mg amber glass vials

      • Bulk quantities: 100mg, 1g, 5g amber glass bottles

      • Custom packaging available upon request

      • Not classified as hazardous material for transport under normal conditions

      • Product for research and analytical use only; not for human or veterinary use

    Shop CAS 18048-64-1 Eltrombopag Intermediate for Pharmaceutical Research  kr-Detailed Image 1

    — Company profile ——


     Shop CAS 1231930-42-9 Abemaciclib Intermediate for Pharma researech use KR-Detailed Image 1

    Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

    Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

    We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

    To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

    Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

     

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    —— Q&A ——

    Q1: How to confirm the product quality before placing orders?
    A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

    Q2: Can you supply free samples?
    A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

    Q3: How do you treat quality complaints?
    A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

    Q4: What is your MOQ? Is there a discount?
    A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
    Q: Is there a discount?
    A: Yes, for larger quantities, we always support with better prices.

    Q5: How to start orders or make payments?
    A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.



    ECHEMI Editorial Reference
    AHU377 and angiotensin IIAT1 receptor antagonist valsartan at a molar ratio of 1: 1 compose LCZ696. LCZ696 was a dual inhibitor of angiotensin II (AT2) receptor and enkephalinase (Neprilysin) receptor. And with its better antihypertensive efficacy than standard antihypertensive drugs, it is a new drug for the treatment of heart failure. AHU377 is a prodrug that converts the active form of the enzyme cleavage LBQ657 ethyl ester. So far its efficacy and safety in milestone phase III surpas.
    Sacubitril is a member of biphenyls.|Sacubitril is a prodrug neprilysin inhibitor used in combination with valsartan to reduce the risk of cardiovascular events in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction. It was approved by the FDA after being given the status of priority review for on July 7, 2015. Sacubitril's active metabolite, LBQ657 inhibits neprilysin, a neutral endopeptidase that would typically cleave natiuretic peptides such as atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and c-type natriuretic peptide (CNP). ANP and BNP are released under atrial and ventricle stress, which activate downstream receptors leading to vasodilation, natriuresis and diuresis. Under normal conditions, neprilysin breaks down other vasodilating peptides and also vasoconstrictors such as angiotensin I and II, endothelin-1 and peptide amyloid beta-protein. Inhibition of neprilysin therefore leads to reduced breakdown and increased concentration of endogenous natriuretic peptides in addition to increased levels of vasoconstricting hormones such as angiotensin II.|Sacubitril is a neprilysn (NEP) inhibitor prodrug with natriuretic activity. Upon administration, sacubitril is metabolized by esterases to its active metabolite, sacubitrilat, which inhibits NEP, a neutral endopeptidase that cleaves natriuretic peptides such as atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and c-type natriuretic peptide (CNP), as well as certain vasoconstricting peptides including as angiotensin I and II, and endothelin-1. Additionally, sacubitrilat may inhibit NEP-mediated catabolism of certain peptide-based agents, thereby improving their in vivo stability and increasing tumor cell exposure.
    ChEBI: Sacubitril is a member of biphenyls.
    Research & Reference Note

    Sacubitril CAS 149709-62-6 98% Purity API Intermediate for Heart Failure Research is listed on ECHEMI for industrial / laboratory sourcing. This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

    Disclaimer: This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

    Reviewed by ECHEMI Scientific Review - Platform editorial review for research chemicals

    Certificates
    • Sacubitril CAS 149709-62-6 98% Purity API Intermediate for Heart Failure Research Certificates 1 TDS

    Basic Info
    Product Name:

    AHU-377

    Other Name:

    4-(((2R,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-Methyl-5-oxopentan-2-yl)aMino)-4-oxobutanoic acid;AHU-377;4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-Methyl-5-oxopentan-2-yl)aMino)-4-oxobutanoic acid;(2R,4S)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester;AHU-377,149709-62-6;AHU-37;AHU377; AHU 377; SACUBITRIL;LCZ696(valsartan + sacubitril) impurity 4

    CAS No.:

    149709-62-6

    Molecular Formula:

    C24H29NO5

    InChIKeys:

    PYNXFZCZUAOOQC-VNLCLAKNNA-N

    Molecular Weight:

    411.49

    Exact Mass:

    411.49

    EC Number:

    1592732-453-0

    UNII:

    17ERJ0MKGI

    DSSTox ID:

    DTXSID20164370

    NCI Thesaurus Code:

    C152281

    Color/Form:

    colorless

    ATC Code:

    C09DX04

    Characteristics
    PSA:

    92.7

    XLogP3:

    3.96

    Density:

    1.151±0.06 g/cm3(Predicted)

    Boiling Point:

    656.9±55.0 °C(Predicted)

    Flash Point:

    351.1±31.5 °C

    Refractive Index:

    1.549

    PKA:

    4.72±0.10(Predicted)

    Critical Temperature & Pressure:

    Sealed in dry,Store in freezer, under -20°C

    Hazard Identification

    Classification of the substance or mixture

    no data available

    GHS label elements, including precautionary statements

    Pictogram(s) no data available
    Signal word

    no data available

    Hazard statement(s)

    no data available

    Precautionary statement(s)
    Prevention

    no data available

    Response

    no data available

    Storage

    no data available

    Disposal

    no data available

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

    Location:

    RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA

    Payment Terms:

    TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    7 days

    Total Annual Revenue:

    $1 million-$2.5 million

    Total Employees:

    11-50

    Year of Establishment:

    2022

    Jinan Topfull Chemical Co., Ltd. is a global chemical Industrial and focuses on advanced chemical technology. Specialized in Cosmetic materials, water treatment, fine chemicals and so on. We are looking forward to working together with the people of all circles at home and abroad to seek common development!
  • Country Product Purchase Quantity Date Posted
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