5-Nitroindole is a nitro-substituted indole derivative supplied as a yellow crystalline powder with a minimum assay of 98.0 percent. As a functionalized nitrogen heterocycle, it serves as a versatile building block and intermediate in organic synthesis, pharmaceutical research and advanced materials studies.

Key Attributes

Key Highlights

• HIGH PURITY: Minimum 98.0 percent assay determined by gas chromatography, with batch-specific COA issued for every shipment.
• CONSISTENT QUALITY: Uniform yellow crystalline powder with a melting range of 140-143 C, indicating a stable and reproducible crystal form from batch to batch.
• VERSATILE BUILDING BLOCK: The nitro group at the C5 position can be reduced to the corresponding amine and activates the ring system toward further substitution, cyclization and coupling transformations.
• PROCESS FRIENDLY: Readily soluble in dichloromethane, ethyl acetate, methanol and ethanol, which suits common reaction media and standard recrystallization workup.
• FLEXIBLE ORDER SIZE: Minimum order quantity of 1 kg, with packing available from small trial quantities up to 25 kg drums for scale-up and production use.
• RELIABLE LEAD TIME: Orders are normally dispatched within 2 weeks after confirmation, supported by stable upstream sourcing.
• FULL DOCUMENTATION: Certificate of analysis and technical documents are supplied with each consignment to support incoming inspection and registration files.
• COMPETITIVE OFFER: Direct supply from Dideu Group with tiered pricing according to order quantity.

Product Description

5-Nitroindole, CAS 6146-52-7, is a nitrated derivative of indole with the molecular formula C8H6N2O2 and a molecular weight of 162.15. It is supplied as a yellow crystalline powder with a minimum purity of 98.0 percent by GC, and is classified under HS code 29339900. The product is intended for industrial and research use as a heterocyclic intermediate and synthetic building block.

From a reactivity standpoint, the nitro substituent at the C5 position exerts a strong electron-withdrawing effect on the bicyclic ring system. This makes 5-nitroindole a useful starting point for two principal transformation routes: catalytic or chemical reduction of the nitro group to yield 5-aminoindole, which is a key precursor for further nitrogen heterocycle construction, and substitution or coupling chemistry on the activated aromatic system. The compound melts at 140-143 C and dissolves readily in dichloromethane, ethyl acetate, methanol and ethanol, allowing straightforward reaction setup, in-process monitoring and purification by recrystallization. Its moderate lipophilicity, with a LogP value of 2.53, is favorable for use in multi-step organic synthesis sequences.

Dideu Group supplies 5-nitroindole with a minimum order quantity of 1 kg and a normal lead time within 2 weeks after order confirmation. Packing covers small trial quantities up to 25 kg drums, and shipments are arranged by air or by sea according to order size and destination. Payment is accepted by T/T and L/C, and each consignment is accompanied by a certificate of analysis and supporting technical documents.

Applications

Organic Synthesis and Heterocyclic Chemistry

5-Nitroindole is widely used as an intermediate in organic synthesis. The C5 nitro group provides a handle for reduction to 5-aminoindole and for further functionalization of the indole nucleus, supporting the construction of substituted indoles, indolines and fused heterocyclic systems.

Pharmaceutical and Agrochemical Intermediates

As a functionalized indole building block, 5-nitroindole may be used in the synthesis of active pharmaceutical ingredient intermediates and agrochemical intermediates that carry a substituted indole or indole-derived scaffold. The 5-amino derivative obtained by nitro reduction is a common entry point for amide, sulfonamide and urea type structures.

Life Science and Nucleic Acid Research

Published research has employed 5-nitroindole as a universal base analog in nucleic acid studies, including investigations of aromatic stacking behavior in DNA and the design of nucleoside-derived cationic lipids for siRNA transfection. It is also used in structure-activity studies of nitroaromatic compounds.

Advanced Materials Research

5-Nitroindole crystals have been studied as an organic nonlinear optical material, where the push-pull character of the nitro group on the indole ring contributes to the second-order optical response of the crystal lattice.

Fine Chemical and Specialty Applications

Based on its heterocyclic structure and reactivity, 5-nitroindole is a candidate for use as a synthetic precursor in the preparation of specialty fine chemicals, including dye and pigment intermediates, corrosion inhibitor components and custom heterocyclic compounds.

Note: The Pharmaceutical and Agrochemical Intermediates and Fine Chemical and Specialty Applications items above are inferred from the molecular structure and reactivity of this compound rather than from documented end uses. Please verify suitability for your specific application.

Specifications

Packaging and Shipping

Storage Recommendations

• Keep the container tightly closed when not in use.
• Store in a cool, dry and well-ventilated place.
• Protect from light to maintain color and assay.
• Keep away from heat sources.

Mode of Transport: By air or by sea, selected according to order quantity and destination.

Lead Time: Within 2 weeks after order confirmation.

Payment Terms: T/T and L/C.

Company Profile

Dideu Group is a professional supplier of fine chemicals and specialty chemicals, serving customers in global markets with a full range of products from lab-scale reagents to industrial quantities. Our portfolio covers heterocyclic building blocks, pharmaceutical and agrochemical intermediates, inorganic salts and custom synthesis products. We work with established manufacturing partners and apply batch-level quality control so that every consignment is released against a documented specification. Each shipment is supported by a certificate of analysis and the technical documents required for incoming inspection and regulatory filing. Our sales and logistics teams handle quotation, packing, documentation and transport coordination, keeping delivery schedules predictable for repeat customers. Dideu Group aims to be a long-term sourcing partner rather than a one-off supplier.

FAQ

1. What is the minimum order quantity for 5-nitroindole?

The minimum order quantity is 1 kg. Smaller trial quantities can also be arranged, and packing scales up to 25 kg drums for production orders.

2. What is the lead time?

Dideu normally dispatches orders within 2 weeks after order confirmation. For larger quantities the exact schedule is confirmed at the quotation stage.

3. What packaging options do you offer?

Standard packing is an aluminum foil bag or HDPE bottle for 100 g, 500 g and 1 kg, and a fiber drum with inner liner for 5 kg, 10 kg and 25 kg. Customized packing can be discussed on request.

4. What payment terms do you accept?

Dideu accepts T/T and L/C. Terms are confirmed in the proforma invoice before production is scheduled.

5. Do you provide COA and technical documents?

Yes. A batch-specific certificate of analysis and supporting technical documents are supplied with every shipment to assist your incoming inspection and filing work.

6. How do you ship the goods?

Shipments are arranged by air or by sea depending on order quantity and destination. Dideu prepares the commercial invoice, packing list and transport documents required for customs clearance.