Product Overview

4-Bromophenylhydrazine hydrochloride is an organic compound with the molecular formula C₆H₈BrClN₂ and molecular weight of 223.50 g/mol. This white to off-white crystalline solid is a valuable intermediate in pharmaceutical, agrochemical, and dye research. The compound features a hydrazine group and a bromine atom on the aromatic ring.

Synthetic Process

• Diazotization: 4-Bromoaniline is diazotized using sodium nitrite in acidic medium

• Reduction: The diazonium salt is reduced using tin(II) chloride or sodium sulfite to yield the hydrazine

• Hydrochloride Formation: The free base is treated with hydrochloric acid to form the hydrochloride salt

• Purification: The crude product is purified by recrystallization from suitable solvents

Mechanism of Action

• Hydrazine Reactivity: The hydrazine group reacts with aldehydes and ketones to form hydrazones

• Fischer Indole Synthesis: Key reagent for the synthesis of indole derivatives

• Cross-Coupling Substrate: The aryl bromide enables Suzuki-Miyaura and other coupling reactions

Research Applications & Market Significance

• Pharmaceutical Research: Building block for drug discovery programs

• Dye Synthesis: Intermediate for azo dyes and other colorants

• Agrochemical Synthesis: Intermediate for herbicide and pesticide production

• Organic Synthesis: Versatile intermediate for functionalized aromatic compounds

Quality Specifications

• Purity: ≥98.0% determined by HPLC

• Melting point: 218-222°C (dec.)

• Loss on drying: ≤0.5%

• Storage: 2-8°C, sealed, protected from light

• Stable for 24 months when properly stored

Packaging & Shipping

• Research quantities: 25g, 100g amber glass bottles

• Bulk quantities: 500g, 1kg amber glass bottles

• Shipped at ambient temperature