—— Product Specifications ——

—— Product Detail ——

Product Overview

NSI-189 (CAS 1270138-40-3) is a neurogenic compound with the molecular formula C₁₆H₁₉N₃O and a molecular weight of 269.34 g/mol. Chemically, it is (1-benzylpiperidin-4-yl)(4-pyrrolidin-1-ylphenyl)methanone or related derivatives. NSI-189 is a cognitive enhancer that has been studied for its potential to stimulate neurogenesis in the hippocampus. It is a white to off-white crystalline powder with good solubility in organic solvents and limited aqueous solubility. The compound is stable under proper storage conditions and is supplied at ≥99% purity.

Synthetic Process

The synthesis of NSI-189 involves multiple steps including the formation of the piperidine ring, benzylation, and coupling with the pyrrolidinophenyl moiety. Key reactions include reductive amination, Friedel-Crafts acylation, and purification via recrystallization or column chromatography.

Mechanism of Action

NSI-189 acts through multiple neurogenic mechanisms: - Neurogenesis Stimulation: Promotes the proliferation and differentiation of neural progenitor cells - Hippocampal Effects: Enhances hippocampal neurogenesis, which is associated with mood and cognitive function - Cognitive Enhancement: Improves cognitive function in research models - Neuroprotective Effects: May provide neuroprotection through growth factor support

Quality Specifications

• Purity: ≥99.0% determined by HPLC

• Identity confirmed by NMR and mass spectrometry

• Each batch accompanied by comprehensive Certificate of Analysis (COA)

• Store in a cool, dry place protected from light

Packaging & Shipping

• Research quantities: 1g, 5g, 10g amber glass vials

• Bulk quantities: 25g, 100g, 500g amber glass bottles

• Custom packaging available upon request

— C ompany Profile ——

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

—— Q&A ——

Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

Q4: What is your MOQ? Is there a discount?
A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.

Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.