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Methyl 4-bromo-2-fluorobenzoate High Purity Organic Intermediate CAS 433-19-2 Research Grade Reagent for Pharmaceutical and Agrochemical Synthesis buy - large image1

Methyl 4-bromo-2-fluorobenzoate High Purity Organic Intermediate CAS 433-19-2 Research Grade Reagent for Pharmaceutical and Agrochemical Synthesis

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Unit Price:

$30-35/KG FOB

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CAS No.:

433-19-2

Grade:

Reagent Grade

Content:

99%

Port:

qingdao

Brand:

Packaging:

1g/vial, 5g/vial, 25g/vial, 100g/vial

Sample Available:

Yes

Price valid (until):

2026-11-08

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Jinan topfull chemical co.,ltd

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

7 days

Qualification:

Main Products:

Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

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Product Details
Seller Information

Description

—— Product Specifications ——

Shop Methyl 4-bromo-2-fluorobenzoate High Purity Organic Intermediate CAS 433-19-2 Research Grade Reagent for Pharmaceutical and Agrochemical Synthesis-Detailed Image 1

—— Product Detail ——

- - - - Product Overview
        
        Methyl 4-bromo-2-fluorobenzoate is an organic compound with the molecular formula C₈H₆BrFO₂ and molecular weight of 233.04 g/mol. This colorless to light yellow liquid is a valuable intermediate in pharmaceutical and agrochemical research. The compound features a bromine atom at the 4-position, a fluorine atom at the 2-position, and a methyl ester group on the aromatic ring.
        
        Synthetic Process
        
        Esterification: 4-Bromo-2-fluorobenzoic acid is esterified with methanol in the presence of an acid catalyst
        
        Purification: The crude product is purified by fractional distillation
        
        Quality Control: The final product is analyzed to ensure ≥98.0% purity by GC
        
        Mechanism of Action
        
        Cross-Coupling Substrate: The aryl bromide enables Suzuki-Miyaura and other coupling reactions
        
        Ester Functionalization: The methyl ester can be hydrolyzed to the corresponding carboxylic acid or reduced to the alcohol
        
        Fluorinated Building Block: The fluorine atom provides unique electronic properties and metabolic stability
        
        Research Applications & Market Significance
        
        Pharmaceutical Research: Building block for drug discovery programs
        
        Agrochemical Synthesis: Intermediate for herbicides and fungicides
        
        Organic Synthesis: Versatile intermediate for functionalized benzoate derivatives
        
        Material Science: Used in the preparation of specialty polymers
        
        Quality Specifications
        
        Purity: ≥98.0% determined by GC
        
        Boiling point: 120-122°C (15 mmHg)
        
        Density: 1.577 g/mL at 25°C
        
        Refractive index: n²⁰/D 1.537
        
        Storage: 2-8°C, sealed, protected from light
        
        Stable for 24 months when properly stored
        
        Packaging & Shipping
        
        Research quantities: 25g, 100g amber glass bottles
        
        Bulk quantities: 500g, 1kg amber glass bottles
        
        Shipped at ambient temperature

— C ompany Profile ——

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

—— Q&A ——

Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

Q4: What is your MOQ? Is there a discount?
A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.

Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.

ECHEMI Editorial Reference

clear colorless liquid

Certificates

Basic Info

Product Name:

1,4-Bis(trifluoromethyl)benzene

Other Name:

Benzene,1,4-bis(trifluoromethyl)-;p-Xylene,α,α,α,α′,α′,α′-hexafluoro-;1,4-Bis(trifluoromethyl)benzene;α,α,α,α′,α′,α′-Hexafluoro-p-xylene;p-Bis(trifluoromethyl)benzene;p-Trifluoromethylbenzotrifluoride;1,4-Di(trifluoromethyl)benzene;NSC 61992;p-Xylene hexafluoride;PTF-TFM

CAS No.:

433-19-2

Molecular Formula:

C8H4F6

InChIKeys:

InChIKey=PDCBZHHORLHNCZ-UHFFFAOYSA-N

Molecular Weight:

214.11

Exact Mass:

214.11

BRN:

1912445

EC Number:

207-086-0

UNII:

A7C3RX7Y2R

NSC Number:

61992

DSSTox ID:

DTXSID1059991

HScode:

2903999090

Categories:

Organic Reagents

Characteristics

PSA:

XLogP3:

3.83

Appearance:

Colorless liquid.

Density:

1.4±0.1 g/cm3

Melting Point:

-1°C

Boiling Point:

116 °C

Flash Point:

71 °F

Refractive Index:

1.380

Storage Conditions:

Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area.

Vapor Pressure:

22.1mmHg at 25°C

See More 1,4-Bis(trifluoromethyl)benzene Properties 

Hazard Identification

Classification of the substance or mixture

Flammable liquids, Category 2

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H225 Highly flammable liquid and vapour H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P264 Wash ... thoroughly after handling. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse affected areas with water [or shower]. P370+P378 In case of fire: Use ... to extinguish. P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P235 Store in a well-ventilated place. Keep cool. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 1,4-Bis(trifluoromethyl)benzene Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

Location:
RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA

Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
7 days

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
11-50

Year of Establishment:
2022

Jinan Topfull Chemical Co., Ltd. is a global chemical Industrial and focuses on advanced chemical technology. Specialized in Cosmetic materials, water treatment, fine chemicals and so on. We are looking forward to working together with the people of all circles at home and abroad to seek common development!
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Methyl 4-bromo-2-fluorobenzoate High Purity Organic Intermediate CAS 433-19-2 Research Grade Reagent for Pharmaceutical and Agrochemical Synthesis

Product Details

Seller Information