Product Overview

2-Bromothiazole is an organic compound with the molecular formula C₃H₂BrNS and molecular weight of 164.02 g/mol. This colorless to light yellow liquid is a valuable intermediate in pharmaceutical, agrochemical, and material science research. The compound features a bromine atom at the 2-position of the thiazole ring.

Synthetic Process

• Bromination: Thiazole is brominated using elemental bromine or NBS in the presence of a catalyst to yield the 2-brominated product

• Purification: The crude product is purified by fractional distillation

• Quality Control: The final product is analyzed to ensure ≥98.0% purity by GC

Mechanism of Action

• Cross-Coupling Substrate: The heteroaryl bromide enables Suzuki-Miyaura and other coupling reactions

• Heterocyclic Reactivity: The sulfur and nitrogen atoms provide unique electronic properties

• Pharmaceutical Relevance: Thiazole derivatives exhibit various biological activities

Research Applications & Market Significance

• Pharmaceutical Research: Building block for drug discovery programs

• Agrochemical Synthesis: Intermediate for pesticide development

• Material Science: Used in the preparation of organic semiconductors and functional materials

• Organic Synthesis: Versatile intermediate for functionalized thiazole derivatives

Quality Specifications

• Purity: ≥98.0% determined by GC

• Boiling point: 171-173°C

• Density: 1.840 g/mL at 25°C

• Refractive index: n²⁰/D 1.587

• Storage: 2-8°C, sealed, protected from light

• Stable for 24 months when properly stored

Packaging & Shipping

• Research quantities: 5g, 25g amber glass vials

• Bulk quantities: 100g, 500g amber glass bottles

• Shipped at ambient temperature