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O-304 1261289-04-6

Name: O-304 1261289-04-6
Brand: OORENT
SKU: pr2610101098
Price: 33 USD
Availability: InStock

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Unit Price:

$33-34/MT FOB

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CAS No.:

1261289-04-6

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

shanghai

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Sample Available:

Yes

Price valid (until):

2026-11-10

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Payment Terms:

100% TT in advance

Average Lead Time:

10 days

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Product Detailv

O-304 Basic information

Product Name:	O-304
Synonyms:	O-304;O-304 1261289-04-6;4-chloro-N-(2-(4-chlorobenzyl)-3-oxo-2,3-dihydro-1,2,4-thiadiazol-5-yl)benzamide;CS-2682;0 304;O-304;0 304;Benzamide, 4-chloro-N-[2-[(4-chlorophenyl)methyl]-2,3-dihydro-3-oxo-1,2,4-thiadiazol-5-yl]-;O 304,AMPK,O-304,inhibit,Inhibitor,AMP-activated protein kinase,O304
CAS:	1261289-04-6
MF:	C16H11Cl2N3O2S
MW:	380.25
EINECS:	202-303-5
Product Categories:	API
Mol File:	1261289-04-6.mol

O-304 Chemical Properties

density	1.50±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:30): 0.03 mg/ml; Ethanol: slightly soluble
form	A crystalline solid
pka	7.81±0.20(Predicted)
color	White to off-white
InChI	InChI=1S/C16H11Cl2N3O2S/c17-12-5-1-10(2-6-12)9-21-16(23)20-15(24-21)19-14(22)11-3-7-13(18)8-4-11/h1-8H,9H2,(H,19,20,22,23)
InChIKey	WEDWLYRQKUTOAX-UHFFFAOYSA-N
SMILES	C(NC1SN(CC2=CC=C(Cl)C=C2)C(=O)N=1)(=O)C1=CC=C(Cl)C=C1

Safety Information

MSDS Information

O-304 Usage And Synthesis

Uses	O-304 is a first-in-class, orally available pan-AMPK activator, which increases AMPK activity by suppressing the dephosphorylation of pAMPK. O-304 exhibits a great potential as a agent to treat type 2 diabetes (T2D) and associated cardiovascular complications [1][2].
Mechanism of action	O-304 acts as an AMPK-specific activator to treat testosterone propionate-induced benign prostatic hyperplasia (BPH) in rats via oral administration[3]. Its mechanism of action involves the specific activation of AMPK, which in turn activates the downstream PGC-1α signalling pathway, thereby inhibiting inflammation, proliferation and mitochondrial dysfunction associated with the progression of BPH, and thus exerting a potential therapeutic effect on BPH.
in vivo	O-304 increases glucose uptake in skeletal muscle, reduces β cell stress, and promotes β cell rest in diet-induced obese mice. O-304 reduces fasting plasma glucose levels and homeostasis model assessment of insulin resistance (HOMA-IR) in a proof-of-concept phase IIa clinical trial in type 2 diabetes (T2D) patients on Metformin^[2].
References	[1] Periodic Reporting for period 1-AMPK-DIAB (A small molecule AMP activated protein kinase (AMPK) activator, denoted O304, as a novelinnovative drug for the treatment of type 2 diabetes). [3] Yongzhi Li. (2021). SIRT3 affects mitochondrial metabolic reprogramming via the AMPK-PGC-1α axis in the development of benign prostatic hyperplasia. Prostate, 81 15, 1135–1148. https://doi.org/10.1002/pros.24208

O-304 Preparation Products And Raw materials

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Basic Info

Product Name:

O-304

Other Name:

O-304;O-304 1261289-04-6;4-chloro-N-(2-(4-chlorobenzyl)-3-oxo-2,3-dihydro-1,2,4-thiadiazol-5-yl)benzamide;CS-2682;0 304;O-304;0 304;Benzamide, 4-chloro-N-[2-[(4-chlorophenyl)methyl]-2,3-dihydro-3-oxo-1,2,4-thiadiazol-5-yl]-;O 304,AMPK,O-304,inhibit,Inhibitor,AMP-activated protein kinase,O304

CAS No.:

1261289-04-6

Molecular Formula:

C16H11Cl2N3O2S

InChIKeys:

WEDWLYRQKUTOAX-UHFFFAOYSA-N

Molecular Weight:

380.25

Exact Mass:

378.995

EC Number:

202-303-5

Color/Form:

White to off-white

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

92.23

XLogP3:

3.9852

Density:

1.50±0.1 g/cm3(Predicted)

PKA:

7.81±0.20(Predicted)

Critical Temperature & Pressure:

Store at -20°C

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10 days

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

53 Inquiries

Country	Product	Purchase Quantity	Date Posted
Russia	Factory Supply Pure 99% CS-2682 O304 O-304 Powder CAS 1261289-04-6	200 G	Aug 9, 2025
Denmark	Factory Supply Pure 99% CS-2682 O304 O-304 Powder CAS 1261289-04-6	500 G	Oct 23, 2025
United States	ATX-304/O-304	15 G	Sep 12, 2026
Portugal	O-304	100 G	Apr 30, 2026
Philippines	O-304	9 KG	Aug 31, 2026
Canada	O-304	100 G	Oct 10, 2026
New Zealand	O-304	200 G	Oct 8, 2026
United States	O-304	1 G	Oct 3, 2026
Netherlands	O-304	10 G	Oct 1, 2026
Denmark	O-304	50 PCS	Sep 30, 2026
United Kingdom	O-304	100 G	Sep 30, 2026
India	O-304	10 G	Sep 22, 2026
United Kingdom	O-304	10 G	Sep 16, 2026
Germany	O-304	10 G	Sep 4, 2026
Thailand	O-304	100 G	Sep 1, 2026
France	RTX-304	20 MG	Aug 13, 2026
United States	o-304 atx-304	100 G	Jun 22, 2026
Canada	ATX-304	10 G	Jun 16, 2026
United States	ATX304 / O304	50 G	May 28, 2026
Singapore	ATX-304	100 G	May 23, 2026

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Product Name	Grade / Content	Price	Supplier Name	Details
99% Pure Raw Powder O-304 CAS 1261289-04-6 ATX-304	Industrial Grade/99	$164-169/G FOB	Hebei Shunxing Import and Export Co.,Ltd	Inquiry
O-304 O304 ATX-304 powder CAS 1261289-04-6 Purity 99% AMPK Inhibitor	Pharmaceutical Grade/99	$1/G EXW	Hubei Meisang Trading Co.,Ltd	Inquiry
99% High Quality O-304 ATX-304 Pharmaceutical Raw Material CAS 1261289-04-6	Pharmaceutical Grade/99	$22-23/G FOB	NATURE INDUSTRIAL LIMITED	Inquiry
High-Quality O-304 CAS 1261289-04-6 Research Chemical ATX-304 O-304	Pharmaceutical Grade/99	$8-9/G FOB	Fulecare	Inquiry
ATX-304	/	$1-1.2/KG FOB	Hangzhou zhongqi chem co.,Ltd	Inquiry

O-304 1261289-04-6

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