NAD+ High purity Nad+ Lyophilized powder with 99% Purity and Factory Price

Biosynthesis and Metabolism

NAD+ levels in cells are maintained through multiple pathways:
De Novo Synthesis: NAD+ can be synthesized from dietary amino acids like tryptophan via the kynurenine pathway.
Preiss-Handler Pathway: Converts dietary nicotinic acid (NA) into NAD+ through intermediate steps.
Salvage Pathway: The predominant pathway in most cells, recycling nicotinamide (NAM), nicotinamide riboside (NR), and nicotinamide mononucleotide (NMN) back into NAD+ to maintain cellular levels. The rate-limiting enzyme in this pathway is nicotinamide phosphoribosyltransferase (NAMPT).
Methylation and Excretion: Excess NAM is methylated by nicotinamide N-methyltransferase (NNMT) and ultimately excreted, regulating NAD+ homeostasis.

Physiological Roles

Energy Metabolism: NAD+ is indispensable for glycolysis, TCA cycle, and oxidative phosphorylation, enabling efficient ATP production.
Redox Homeostasis: Maintains cellular redox balance by cycling between NAD+ and NADH.
DNA Repair and Genomic Stability: Serves as a substrate for PARPs involved in DNA repair mechanisms.
Regulation of Gene Expression: Through sirtuins, NAD+ influences chromatin remodeling and transcriptional regulation.
Immune Response and Inflammation: Modulates immune cell function and inflammatory processes.
Circadian Rhythm: NAD+ levels influence circadian clock regulation via sirtuin activity.
Aging and Disease: Dysregulation or depletion of NAD+ is linked to aging, metabolic disorders, neurodegeneration, cancer, and cardiovascular diseases.

Pharmacokinetics and Cellular Distribution

Our NAD+ CAS 53-84-9 is supplied as a high-purity raw material with strict quality control. The product can be tested by professional analytical methods according to customer requirements. Standard quality documents such as COA, HPLC report, MS report, or other related testing documents can be provided when available. We understand that international buyers often require complete product information before placing an order, so we support detailed specifications, batch information, packaging details, and shipping documents.

As a biochemical raw material, NAD+ should be handled carefully under suitable laboratory conditions. It is generally recommended to store the product in a cool, dry, and sealed environment, away from moisture, heat, and direct sunlight. For long-term storage, low-temperature conditions are usually preferred to help maintain product stability. After opening the package, users should avoid repeated exposure to air and humidity. Proper handling and storage are important for maintaining product quality.

This product is intended for laboratory research, biochemical research, and further manufacturing use only. It is not intended for human consumption, medical treatment, diagnostic use, food use, or direct personal use. Customers should evaluate the product according to their own research purpose, application requirements, and local regulations before purchase. We recommend that all buyers confirm the required purity, testing standards, packaging size, and shipping method before placing an order.

With high purity, stable quality, flexible packaging, and professional service, NAD+ CAS 53-84-9 is a suitable choice for biochemical research suppliers, laboratory reagent distributors, and companies looking for reliable raw material sources. We welcome inquiries for product specifications, price, available stock, packaging details, quality documents, and shipping information.