Product Overview

Benzenesulfonyl chloride is an organic compound with the molecular formula C₆H₅ClO₂S and molecular weight of 176.62 g/mol. This colorless to light yellow liquid is a widely used sulfonylating agent in organic synthesis. The compound features a sulfonyl chloride group attached to a benzene ring.

Synthetic Process

• Chlorination: Benzenesulfonic acid is reacted with thionyl chloride, phosphorus pentachloride, or chlorosulfonic acid to form benzenesulfonyl chloride

• Purification: The crude product is purified by fractional distillation

• Quality Control: The final product is analyzed to ensure ≥99.0% purity by GC

Mechanism of Action

• Sulfonylating Agent: The sulfonyl chloride group reacts with amines to form sulfonamides and with alcohols to form sulfonate esters

• Hinsberg Test: Used for the separation and identification of primary, secondary, and tertiary amines

• Friedel-Crafts Sulfonylation: Used for the introduction of sulfonyl groups onto aromatic rings

Research Applications & Market Significance

• Pharmaceutical Research: Building block for drug discovery programs

• Organic Synthesis: Key reagent for the preparation of sulfonamides and sulfonate esters

• Agrochemical Synthesis: Intermediate for pesticide development

• Dye Industry: Intermediate for the preparation of dyes and pigments

Quality Specifications

• Purity: ≥99.0% determined by GC

• Boiling point: 251-253°C

• Density: 1.384 g/mL at 25°C

• Refractive index: n²⁰/D 1.551

• Flash point: >110°C

• Storage: 2-8°C, sealed, protected from moisture

• Stable for 24 months when properly stored

Packaging & Shipping

• Research quantities: 100mL, 500mL amber glass bottles

• Bulk quantities: 1L, 2.5L amber glass bottles

• Shipped at ambient temperature under inert atmosphere