Factory Direct 99% Purity Retatrutide CAS 2381089-83-2 In Stock for Glucose Metabolism Research

Retatrutide (LY3437943) acetate is a triple agonist peptide for the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R).

Retatrutide acetate inhibits human GCGR, GIPR, and GLP-1R with EC50 values of 5.79, 0.0643, and 0.775 nM, respectively. It exhibits activity on mouse GCGR, GIPR, and GLP-1R with EC50 values of 2.32, 0.191, and 0.794 nM, respectively.

In vivo, Retatrutide (LY3437943) acetate engages with GCGR and enhances glucose tolerance in an ipGTT by acting through GIP or GLP-1 receptors. Activation via the glucagon receptor by Retatrutide acetate leads to significant weight reduction and increased energy expenditure. Retatrutide acetate can be utilized in research related to obesity.

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Product Name: Retatrutide
Other Name: Retatrutide;GIPR/GLP-1R;LY3437943Retatrutide;Retalutide;Retatrutide (sodium salt);Retatrutide RT5;retatrutide 5mg;Retatratide
CAS No.: 2381089-83-2
InChIKeys: MLOLQJNKXBNWFW-SAGGEDDASA-N
Molecular Weight: 0
EC Number: 200-001-8
Color/Form: White lyophilized
Categories: Bulk Drug Intermediates

Water Solubility: Soluble in water (5mg/ml).
Storage Conditions: -20°C
Critical Temperature:-20℃

Class: Triple agonist — GCGR, GIPR, GLP-1R
Status: Investigational (Phase 3)
Mechanism: Simultaneously activates glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). Engineered from the native GIP backbone with amino acid substitutions to confer GCGR and GLP-1R activity.
EC50 (Human GCGR): 5.79 nM
EC50 (Mouse GIPR): 0.191 nM
EC50 (Mouse GLP1R): 0.794 nM
EC50 (Mouse GCGR): 2.32 nM
EC50 (Human GLP1R): 0.775 nM
EC50 (Human GIPR): 0.0643 nM
Source: Jastreboff AM, et al. N Engl J Med. 2023;389(6):514-526.DOI
Clinical Development: NCT04881760; NCT05882045; NCT06354660

ChEMBL: CHEMBL5095485
DrugBank: DB18993
KEGG DRUG: D12430
PubChem: PubChem
Literature: NEJM: Jastreboff et al. (2023) — Phase 2 Trial; FDA Drugs@FDA
Disclaimer: Retatrutide is an investigational compound not yet approved by FDA or EMA. This listing is for industrial and laboratory research use only. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.