CAS 859216-15-2Quality Peptides Raw Powder Factory Adipotide

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It is a synthetic, small molecule that acts like a pair of "intelligent scissors." Its sole mission is to accurately locate and cut off the "supply lines"—the blood vessels—that deliver nutrients to the body's stubborn fat (especially visceral and subcutaneous fat), causing the fat cells to shrink and die from lack of sustenance.



Think of it as a "special forces operation" against fat:

1. Step 1: Precision Targeting (Identify the "Bad Guys")

   • The body's fat tissue has its own dedicated "supply network" of blood vessels. The surface of these vessels has a special "address tag" (specific proteins like Prohibitin and ANXA2).

   • Adipotide is like a "smart missile." Its "guidance system" can accurately recognize and lock onto this "address tag" that is unique to fat blood vessels.

2. Step 2: Mission Execution (Cut the Supply Lines)

   • Once it "locks on" to a fat blood vessel, Adipotide's "warhead" (the KLA peptide) activates.

   • It attacks the "engine" (mitochondria) of the vascular cells, giving them a "self-destruct" order. The result is that the capillary network supplying the fat is destroyed and disintegrates.

3. Step 3: The Final Outcome (Starve the Target)

   • Fat cells are like "warehouses" that rely on supply lines (blood vessels) to deliver "supplies" (oxygen and nutrients). Once the supply lines are cut, the fat in the warehouse can't be mobilized, and new supplies can't get in.

   • Deprived of nourishment, the fat cells continuously shrink and are eventually cleaned up as waste by the body's clean-up crew (the immune system). This leads to actual thinning and reduction of the fat layer.

Under ideal, controlled conditions, Adipotide once showed promising advantages:
Highly Targeted and Direct:​ Unlike general weight-loss drugs that work systemically by suppressing appetite or boosting metabolism, it directly "destroys" the fat tissue itself, theoretically making it more efficient.
Potentially Fast-Acting:​ In monkey studies, significant body fat reduction was observed within weeks.

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ECHEMI Editorial Reference
Adipotide is a synthetic chimeric peptidomimetic composed of a prohibitin-targeting peptide and a pro-apoptotic peptide sequence. Its defined structure, commonly represented as CKGGRAKDC-GG-D(KLAKLAK)₂, combines a vascular-targeting domain with a pro-apoptotic domain. As a specialized peptide research and pharmaceutical raw material, Adipotide is suitable for biochemical research, analytical studies, and pharmaceutical development.

Basic Info
Product Name:HKPao
Other Name:D-Lysine, L-cysteinyl-L-lysylglycylglycyl-L-arginyl-L-alanyl-L-lysyl-L-α-aspartyl-L-cysteinylglycylglycyl-D-lysyl-D-leucyl-D-alanyl-D-lysyl-D-leucyl-D-alanyl-D-lysyl-D-lysyl-D-leucyl-D-alanyl-D-lysyl-D-leucyl-D-alanyl-;Adipotide Powder;Weight Loss Peptides Adipotide Adipotide Ftpp;HKPao;Adipotide (FTPP) 5mg 10mg;Prohibitin-targeting peptide 1D-Lysine, L-cysteinyl-L-lysylglycylglycyl-L-arg…
CAS No.:859216-15-2
Molecular Formula:C111H206N36O28S2
InChIKeys:GZESIPHLGJDZRG-XRIURATCNA-N
Molecular Weight:2557.21
EC Number:200-001-8
Categories:Polypeptide

Characteristics
Density:1.40±0.1 g/cm3(Predicted)

Research
Class:Chimeric peptidomimetic (fat-targeting vascular disruptor)Chimeric peptidomimetic (fat-targeting vasc…
Status:Research compound — Not FDA approved, clinical development discontinuedResearch compound — Not FDA approved, c…
Mechanism:A synthetic chimeric peptide composed of a fat-vascular-targeting cyclic peptide (CKGGRAKDC) linked via a GG spacer to a pro-apoptotic peptide (KLAKLAK)2. Adipotide selectively binds prohibitin in the vasculature of white adipose tissue, then delivers the pro-apoptotic domain to induce vascular disruption, causing fat tissue death. In primate studies (2011), it produced significant weight loss (~11%) but also caused renal toxicity, leading to development discontinuation.A synthetic chimeric peptide composed of a f…
Activity note:Adipotide is not a receptor agonist. It functions as a targeted vascular disruptor. Functional activity is measured by tissue-specific apoptosis, not traditional EC50.Adipotide is not a receptor agonist. It functio…
Source:PubChem: Adipotide (CID 163360068); Kolonin MG, et al. Sci Transl Med. 2004;6(148):148ra16.PubChem: Adipotide (CID 163360068); Koloni…DOI

References
PubChem:PubChem
Literature:Sci Transl Med: Kolonin MG, et al. (2004) — Adipotide mechanism; ChemicalBook: Adipotide (CAS 859216-15-2)
Disclaimer:Adipotide is NOT FDA-approved or EMA-approved. It is a research compound only. Clinical development was discontinued due to renal toxicity observed in primate studies. This listing is for industrial and laboratory research use only. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.