Hyaluronic acid (HA) is a glycosaminoglycan that occurs naturally in the skin. It possesses a remarkable capacity to absorb and retain large amounts of water, helping the skin stay hydrated. Within the dermis, hyaluronic acid works alongside collagen and elastin to provide structural support, thereby maintaining skin elasticity.
▶ Widely applied in:
☑ Ophthalmology ☑ Arthrology ☑ Pulmonology ☑ Rhinology
☑ Aesthetic Medicine ☑ Oncology ☑ Nutrition ☑ Cosmetics
Benefits of Exogenous Hyaluronic Acid
How Hyaluronic Acid Provides Hydration
Moisturizing and Reducing Fine Lines
When applied topically, high-molecular-weight hyaluronic acid (typically with a molecular weight in the millions) forms a film on the skin’s surface. This film locks in moisture, reduces transepidermal water loss, and leaves the skin feeling softer.
Experimental evidence confirms that low-molecular-weight hyaluronic acid (20–50 kDa) can penetrate into the deeper layers of the epidermis, helping to increase skin hydration and improve elasticity. Furthermore, research indicates that the use of 0.1% low-molecular-weight hyaluronic acid (130 kDa and 50 kDa) over a period of 60 consecutive days can help reduce the depth of skin wrinkles. Topical hyaluronic acid has a wide range of applications. Research indicates that hyaluronic acid gels can facilitate the physiological processes involved in wound healing, thereby reducing the time required for a wound to heal. One study found that a cream containing 0.5% low-molecular-weight hyaluronic acid (20–50 kDa) and 3% high-molecular-weight hyaluronic acid (1–1.4 MDa) significantly improved the appearance of wrinkles around the eyes after 28 consecutive days of use. Another study suggested that a combination of hyaluronic acids with six different molecular weights can help improve the facial appearance of aging skin.
How Hyaluronic Acid Provides Hydration
In general, depending on its molecular weight, hyaluronic acid can absorb moisture, diminish the appearance of wrinkles, and repair the skin. When using hyaluronic acid, it is important to pair it with products that provide hydration and seal in moisture. Because of its inherent properties, hyaluronic acid continuously draws in water; if the skin is not adequately hydrated before applying hyaluronic acid, the substance may instead draw moisture out of the stratum corneum (the outermost layer of the skin), leaving it even drier. Following up with an occlusive (moisture-sealing) product helps prevent water loss and prolongs the hydrating effect.
activity, and promotes memory function.
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