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Minocycline hydrochloride

Minocycline hydrochloride structure

CAS No:
13614-98-7
Formula:
C23H27N3O7.ClH
Chemical Name:
Minocycline hydrochloride
Synonyms:
2-Naphthacenecarboxamide,4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-,hydrochloride (1:1),(4S,4aS,5aR,12aS)-;2-Naphthacenecarboxamide,4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-,monohydrochloride;2-Naphthacenecarboxamide,4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-,monohydrochloride,[4S-(4α,4aα,5aα,12aα)]-;2-Naphthacenecarboxamide,4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-,monohydrochloride,(4S,4aS,5aR,12aS)-;Minocycline hydrochloride;Minocin;Minocycline chloride;Periocline;Klinomycin;Vectrin;Minomycin;NSC 141993;Acnez;Periofeel;11006-27-2;150231-24-6;1071702-75-4;1236362-29-0
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Minocycline hydrochloride is a broad-spectrum tetracycline antibiotic, acting by binding to the bacterial 30S ribosomal subunit and inhibiting protein synthesis.

Minocycline Hydrochloride is the hydrochloride salt of minocycline, a broad spectrum long-acting derivative of the antibiotic tetracycline, with antibacterial and anti-inflammatory activities. Minocycline binds to the bacterial 30S ribosomal subunit and interferes with the binding of tRNA to the ribosomal complex, thereby inhibiting protein translation in bacteria. In addition, minocycline inhibits the inflammatory enzyme 5-lipoxygenase (5LOX) and may impede T cell-microglia interactions; both activities may contribute to minocycline's neuroprotective effects. 5LOX catalyzes the synthesis of inflammatory mediators such as prostaglandins and leukotrienes.|A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections.

Minocycline hydrochloride Basic Attributes

Molecular Weight：

493.93700

Exact Mass：

493.16200

EC Number：

237-099-7

UNII：

0020414E5U

NSC Number：

757120

DSSTox ID：

DTXSID8044545

NCI Thesaurus Code：

C47622

HScode：

2942000000

Characteristics

PSA：

164.63000

XLogP3：

1.68890

Appearance：

crystalline yellow

Melting Point：

155-161 °C (decomp)

Boiling Point：

659.4ºC at 760mmHg

Flash Point：

352.6ºC

Water Solubility：

In water, 52,000 mg/l at 25 deg C.

Storage Conditions：

2-8ºC

Vapor Pressure：

6.33E-28mmHg at 25°C

Collision Cross Section：

208.1 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

UN 3249

wgk germany：

hazard class code：

R36/37/38

safety instructions：

S26-S36

RTECS Number：

QI7630500

Marks：

Stability/Shelf Life：

Light Sensitive

Precautionary statement(s)：

P201, P202, P260, P261, P263, P264, P270, P271, P280, P281, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (92%): Causes skin irritation [Warning Skin corrosion/irritation]|P201, P260, P261, P263, P264, P270, P271, P280, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 50 companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

MeSH Entry Terms：

Akamin

Minocycline hydrochloride Use and Manufacturing

Uses

Second generation tetracycline antibiotic. Antibacterial.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:493.9
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:3
Exact Mass:493.1615779
Monoisotopic Mass:493.1615779
Topological Polar Surface Area:165
Heavy Atom Count:34
Complexity:971
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Minocycline is a semi-synthetic tetracycline antibiotic with antibacterial activity against both Gram-positive and Gram-negative bacteria. Its antibacterial spectrum is basically the same as that of tetracyclines. It exerts its antimicrobial effect by inhibiting protein synthesis. It is relatively sensitive to sensitive Gram-positive bacteria (such as Staphylococcus aureus, Streptococcus, and Neisseria meningitidis) and Gram-negative bacteria (such as Neisseria gonorrhoeae and Haemophilus influenzae), and also has a certain effect on microorganisms such as Chlamydia trachomatis and Ureaplasma.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Minocycline Hydrochloride Capsules
Ingredients	Minocycline Hydrochloride
Indication	1Since tetracyclines can inhibit prothrombin activity, patients treated with anticoagulants should reduce the dose of anticoagulants. 2Since tetracyclines are antibacterial agents that can interfere with (hinder) the bactericidal effect of penicillin, they should be avoided in combination with penicillin. 3Calcium, magnesium, aluminum, and iron preparations may reduce drug absorption when used in combination with this drug. 4The combination of tetracyclines and methoxazole can cause severe nephrotoxicity. 5The simultaneous use of tetracyclines can reduce the efficacy of oral contraceptives.
Specifications	50mg
Manufacturer	TC Pharmaceuticals (Jiangsu) Co., Ltd.

Minocycline hydrochloride ointment
Ingredients	Chemical name: Molecular formula: Molecular weight:
Indication	drugInteractions
Specifications	0.5 g

Minocycline Hydrochloride Tablets
Ingredients	Minocycline Hydrochloride
Indication	1. Since this product can reduce the activity of prothrombin, the dose of anticoagulants should be reduced when it is used in combination with anticoagulants. 2. Since antacids (such as sodium bicarbonate) can reduce the absorption and activity of this product, this product and antacids should be avoided to be taken at the same time. 3. When this product is used in combination with drugs containing aluminum, calcium, magnesium, and iron ions, it can form insoluble complexes, which reduces the absorption of this product. 4. When lipid-lowering drugs cholestyramine or colestipol are used in combination with this product, the absorption of this product may be affected. 5. Since barbiturates, phenytoin or carbamazepine can induce the activity of microsomal enzymes and reduce the blood concentration of this product, the dose of this product must be adjusted when used in combination. 6. The combination of general anesthetic methoxyflurane and this product can lead to fatal nephrotoxicity. 7. Since this product can interfere with the bactericidal activity of penicillin, it should be avoided to use this product in combination with penicillins. 8. The combined use of this product with strong diuretics (such as furosemide, etc.) can aggravate kidney damage. 9. The combined use of this product with other hepatotoxic drugs (such as anti-tumor chemotherapy drugs) can aggravate liver damage. 10. The combined use of this product with oral contraceptives can reduce the effectiveness of oral contraceptives.
Specifications	0.1g
Manufacturer	Dandong Yichuang Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Curia Italy S.r.l.

Japan
Active
CIPAN-Companhia Industrial Produtora de Antibioticos,S.A.

Japan
Active
HOVIONE FARMACIENCIA SA

Japan
Active

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Guide of Minocycline hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
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