2-[4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]acetic acid
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![2-[4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]acetic acid structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220811/5b003b8781074635b2d6fd327b97da7d.png "2-[4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]acetic acid")
2-[4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]acetic acid
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CAS No:
317318-84-6
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Formula:
C21H17F4NO3S2
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Chemical Name:
2-[4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]acetic acid
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Synonyms:
Acetic acid,2-[4-[[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]-;Acetic acid,[4-[[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]-;2-[4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]acetic acid;GWδ 0742;GW 0742;GW 0742X;GW 610742;848749-45-1;861854-14-0
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CAS No:
Description
GW0742 is a high affinity PPAR β/δ agonist with an IC50 of 1 nM for human PPARδ, and EC50s of 1 nM, 1.1 μM and 2 μM for human PPARδ, PPARα, and PPARγ, respectively.
2-[4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]acetic acid Basic Attributes
471.49
471.49
Characteristics
113
6
white solid
1.5±0.1 g/cm3
134.5-135.5 °C
591.476°C at 760 mmHg
311.5±32.9 °C
1.609
DMSO: >5 mg/mL
2-8°C
2-[4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]acetic acid Use and Manufacturing
A small molecule agonist of the human Peroxisome Proliferator-Activated Recept δ (PPAR δ).It shows an EC50 of 1.1 nM against PPAR δ with 100-fold selectivity over the other human subtypes.
Recommended Suppliers of 2-[4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]acetic acid
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![China]()
CN
2 YRS
Business licensedTrader Supplier of Semaglutide,Tirzepatide,Retatrutide,Pharmaceutical Peptide,Cosmetic peptide,Custom peptidesInquiryCAS No.: 317318-84-6Grade: Pharmaceutical GradeContent: 99% -
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2-[4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]acetic acid
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