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Home > Encyclopedia > 2-Pyrazinemethanamine, hydrochloride (1:1)

2-Pyrazinemethanamine, hydrochloride (1:1)

2-Pyrazinemethanamine, hydrochloride (1:1) structure

2-Pyrazinemethanamine, hydrochloride (1:1) 

structure
  • CAS No:

    39204-49-4

  • Formula:

    C5H7N3.ClH

  • Chemical Name:

    2-Pyrazinemethanamine, hydrochloride (1:1)

  • Synonyms:

    2-Pyrazinemethanamine,hydrochloride (1:1);Pyrazinemethanamine,monohydrochloride;(Aminomethyl)pyrazine hydrochloride;2-Aminomethylpyrazine hydrochloride;2-Pyrazinemethanamine hydrochloride

  • Categories:

    Pharmaceutical Intermediates  >  Heterocyclic Compound

2-Pyrazinemethanamine, hydrochloride (1:1) Basic Attributes

145.59

145.040680

2933990090

Characteristics

51.8

245°C at 760 mmHg

102ºC

Safety Information

IRRITANT

2-Pyrazinemethanamine, hydrochloride (1:1) Use and Manufacturing

(Pyrazin-2-ylmethyl)-carbamic acid [(5alpha, 8beta)-1-oxo-2-(4-trifluoromethoxy-phenyl)-2-aza-spiro[4.5]dec-8-yl]ester A solution of [(5alpha, 8beta)-1-oxo-2-(4-(trifluoromethoxy)phenyl)-2-azaspiro[4.5]decan-8-yl]carbonochloridate (135 mg, obtained in example 25, step 1) in DMF (3 mL) was added dropwise over a period of 5 minutes to a suspension of N-ethyldiisopropylamine (0.70 mL) and Example 28(Pyrazin-2-ylmethyl)-carbamic acid [(5a, 8 )-l-oxo-2-(4-trifiuoromethoxy-phenyl)- aza-spiro[4.5]dec-8-yl] esterA solution of [(5a, 8 )-l-oxo-2-(4-(trifiuoromethoxy)phenyl)-2-azaspiro[4.5]decan-8-yl] carbonochloridate (135mg, obtained in example 25, step 1) in DMF (3mL) was added dropwise over a period of 5 minutes to a suspension of N-ethyldiisopropylamine (0.70mL) and EXAMPLE 54 2-[1-(3, 4-Dimethoxy-benzyl)-7, 8-dimethoxy-1, 3, 4, 5-tetrahydro-benzo[c]azepin-2-yl]-2-phenyl-N-pyrazin-2-ylmethyl-acetamide: prepared by reaction of [1-(3, 4-dimethoxy-benzyl)-7, 8-dimethoxy-1, 3, 4, 5-tetrahydro-benzo[c]azepin-2-yl]-phenyl-acetic acid with REFERENCE EXAMPLE 16-1 N-(2-pyrazinylmethyl)-3-chloropropionamide To an aqueous solution of sodium hydroxide (2.31 g) in water (30 ml) was added

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