 Home > Encyclopedia > Citalopram

Citalopram

Citalopram structure

CAS No:
59729-33-8
Formula:
C20H21FN2O
Chemical Name:
Citalopram
Synonyms:
5-Isobenzofurancarbonitrile,1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-;1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile;Lu 10-171;Citalopram;Nitalapram;(±)-Citalopram;1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile;Bonitrile;1-(3-Dimethylaminopropyl)-1-(4-fluorophenyl)-5-cyanophthalan;Prepram;1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile;103146-27-6;128196-03-2
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

ChEBI: A nitrile that is 1,3-dihydro-2-benzofuran-5-carbonitrile in which one of the hydrogens at position 1 is replaced by a p-fluorophenyl group, while the other is replaced by a 3-(dimethylamino)propyl group.

Citalopram Basic Attributes

Molecular Weight：

324.39

Exact Mass：

324.39

EC Number：

261-891-1

Characteristics

PSA：

36.3

XLogP3：

3.5

Appearance：

Solid

Density：

1.2±0.1 g/cm3

Melting Point：

156-157 °C

Boiling Point：

178 °C

Flash Point：

212.8±28.7 °C

Refractive Index：

1.591

Water Solubility：

Sparingly soluble

Storage Conditions：

Store at RT

Vapor Pressure：

1.13X10-7 mm Hg at 25 °C (est)

PKA：

9.78None

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

3249

Stability/Shelf Life：

Stable under recommended storage conditions. /Citalopram hydrobromide/

Precautionary statement(s)：

P201, P202, P261, P264, P270, P271, P272, P273, P280, P281, P301+P312, P302+P352, P304+P340, P305+P351+P338, P308+P313, P312, P321, P330, P333+P313, P337+P313, P363, P391, P403+P233, P405, P501

Hazard Statements：

H302

Citalopram Use and Manufacturing

antidepressant monoamine oxidase inhibitor (MAOIs)

Computed Properties

Molecular Weight:324.4
XLogP3:3.2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:324.16379146
Monoisotopic Mass:324.16379146
Topological Polar Surface Area:36.3
Heavy Atom Count:24
Complexity:466
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Citalopram is an antidepressant and a dicyclic hydrogenated phthalide derivative. Its antidepressant mechanism may be related to inhibiting the reuptake of 5-HT by neurons in the central nervous system, thereby enhancing the function of central serotonergic nerves. In vitro and animal experiments indicate that citalopram is a highly selective 5-HT reuptake inhibitor with little effect on the reuptake of norepinephrine and dopamine. Rats were given citalopram for 14 days, and the effect of inhibiting 5-HT uptake was not tolerated. Citalopram is a racemic body, and its effect of inhibiting 5-HT reuptake is mainly exerted by its (S)-enantiomer. Citalopram has no obvious affinity for 5-HT1A, 5-HT2A, D1 receptor, D2 receptor, а1 receptor, а2 receptor, β receptor, H1 receptor, GABA receptor, etc.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Citalopram Hydrobromide Capsules
Ingredients	(±)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-cyanoisobenzofuran hydrobromide
Indication	This product cannot be taken with monoamine oxidase inhibitors (such as isocarboxazid and moclobemide used to treat depression, and deprenyl hydrochloride used to treat Parkinson's disease), otherwise it will cause serious side effects. The interval between the use of this product and monoamine oxidase inhibitors should be more than 14 days. However, if a reversible monoamine oxidase inhibitor with a short half-life, such as moclobemide (half-life of 1 to 2 hours), is used, it can be used one day after stopping the medication. Central nervous system drugs - Since citalopram mainly acts on the central nervous system, it should be used with caution when used in combination with other drugs that act on the central nervous system. Alcohol - Although citalopram did not enhance the effects of alcohol on sensory and motor nerves in clinical trials, like other drugs for the treatment of psychiatric disorders, it is recommended to take citalopram with a depressant.
Specifications	20mg (calculated as Citalopram)
Manufacturer	Sichuan Kelun Pharmaceutical Co., Ltd.

Registered Holders

FABBRICA ITALIANA SINTETICI SPA

United States
Inactive

Recommended Suppliers of Citalopram

Hangzhou Hyper Chemicals Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

High Quality 99% Citalopram CAS 59729-33-8 Powder Fast Shipping Good Price

CAS No.: 59729-33-8

Grade: Pharmaceutical Grade

Content: 99.5%

Inquiry