 Home > Encyclopedia > Ranitidine hydrochloride

Ranitidine hydrochloride

Ranitidine hydrochloride structure

CAS No:
66357-59-3
Formula:
C13H22N4O3S.ClH
Chemical Name:
Ranitidine hydrochloride
Synonyms:
1,1-Ethenediamine,N-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N′-methyl-2-nitro-,hydrochloride (1:1);1,1-Ethenediamine,N-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N′-methyl-2-nitro-,monohydrochloride;Ranitidine hydrochloride;AH 19065;Zantac;Ranigast;Ranuber;Normon;Azantac;Ultac;Sostril;Raniogas;Urantac;Rantacid;Antagonin;Ranisen;Ranix;Ezopta;Ranacid;Radinat;Histac;Achedos;Xanidine;Axoban;Raticina;Ratic;Histak;Zinetac;Ranitiget;Ulcex;Ulceranin;Ulceran;Consec;Quicran;Raniplex;Anistal;Rosimol;Simetac;Lydin;Apozan;Rantac;Aciloc;Apo-Ranitidine;Randin;Ptinolin;Eltidine;Gastrosedol;Raniben;Zantab;Zantadin;Galidrin;Vesyca;Microtid;Ranidil;Ulcirex;Coralen;Rani 2;Ranimex;Gastridin;Gastrial;Neoceptin R;Ranial;Aldin;Zantic;Atural;Weidos;Ranital;RND;Rantin;Acloral;Ranin;Vizerul;Ulsal;Ranidine;Ul-Pep;Weichilin;Verlost;Acidex;Curan;Taural;Quantor;Trigger;Melfax;Terposen;Noctone;Ultidine;Ranitidine-akri;Rantidol;Ranitin;Zintac;Ranitab
Categories:
Active Pharmaceutical Ingredients > Digestive System Drugs

Description

Ranitidine is a histamine H2-receptor antagonist that inhibits stomach acid production. Target: Histamine H2-ReceptorRanitidine (Zantac) is a histamine H2-receptor antagonist with IC50 of 3.3 ± 1.4 uM. It inhibits stomach acid production. It is also used alongside fexofenadine and other antihistamines for the treatment of skin conditions such as hives. It has 10% the affinity that cimetidine has to CYP450 so it causes fewer side effects, but other H2 blockers famotidine and nizatidine ha

A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.

Ranitidine hydrochloride Basic Attributes

Molecular Weight：

350.86

Exact Mass：

350.117950

EC Number：

266-332-5

DSSTox ID：

DTXSID0052835

HScode：

2933990090

Characteristics

PSA：

112 Å²

XLogP3：

3.56600

Appearance：

tan solid

Melting Point：

133-134 °C

Water Solubility：

soluble in water, 2-hydroxypropyl-beta-cyclodextrin, acetic acid, methanol, ethanol and dimethyl sulfoxide. Insoluble in chloroform.

Storage Conditions：

Hygroscopic, -20°C Freezer, Under Inert Atmosphere

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

20/21/22-39/23/24/25-23/24/25-11

safety instructions：

22-24/25-45-36/37-16-7

RTECS Number：

KM6557000

Marks：

F,T

GHS Classification：

|Danger|H315 (89.04%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P272, P280, P285, P302+P352, P304+P340, P304+P341, P305+P351+P338, P312, P321, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 76 companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)|Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood. (See all compounds classified as Histamine H2 Antagonists.)

MeSH Entry Terms：

AH 19065

Ranitidine hydrochloride Use and Manufacturing

Uses

antifungal

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:350.87
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:9
Exact Mass:350.1179395
Monoisotopic Mass:350.1179395
Topological Polar Surface Area:112
Heavy Atom Count:22
Complexity:347
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It competitively blocks the binding of histamine to H2 receptors, inhibiting gastric acid secretion. It is a potent H2 receptor blocker, and its gastric acid inhibition effect is 5 to 12 times that of cimetidine.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Ranitidine Hydrochloride Capsules
Ingredients	Ranitidine hydrochloride, its chemical name is: N'-methyl-N-[2-[[[5-[(dimethylamino)methyl]-2-furyl]-methyl]thio]ethyl]-2-nitro-1,1-ethylenediamine hydrochloride.
Indication	1. When used with warfarin, lidocaine, diazepam, propranolol and other drugs that are metabolized by the liver, the blood concentration of ranitidine will not increase and cause toxic side effects. 2. When used with anticoagulants and anti-epileptic drugs, it is safer than cimetidine. 3. When used with procainamide, the clearance rate of procainamide can be reduced. 4. It can reduce liver blood flow, so when used with propranolol, lidocaine and other drugs whose metabolism is greatly affected by liver blood flow, it can delay the effects of these drugs.
Specifications	0.15 g (calculated as C13H22N4O3S)

Ranitidine hydrochloride

Ranitidine Hydrochloride Capsules
Ingredients	Ranitidine hydrochloride, its chemical name is: N'-methyl-N-[2-[[[5-[(dimethylamino)methyl]-2-furyl]-methyl]thio]ethyl]-2-nitro-1,1-ethylenediamine hydrochloride.
Indication	1. When used with warfarin, lidocaine, diazepam, propranolol and other drugs that are metabolized by the liver, the blood concentration of ranitidine will not increase and cause toxic side effects. 2. When used with anticoagulants and anti-epileptic drugs, it is safer than cimetidine. 3. When used with procainamide, the clearance rate of procainamide can be reduced. 4. It can reduce liver blood flow, so when used with propranolol, lidocaine and other drugs whose metabolism is greatly affected by liver blood flow, it can delay the effects of these drugs.
Specifications	0.15g (calculated as C13H22N403S)
Manufacturer	Shaanxi Panlong Pharmaceutical Group Limited By Share Ltd

See More Related Drugs

Registered Holders

ORCHEV PHARMA PVT LTD

India
Active
QUIMICA SINTETICA SA

Spain
Active
Shanghai Huiren (Xiayi) Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of Ranitidine hydrochloride

Hainan Flying International Trade Co., L Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of vitamin

Top Quality API 99% Ranitidine Hydrochloride powder 66357-59-3 pure Ranitidine HCl

CAS No.: 66357-59-3

Grade: Food grade

Content: 99%

Inquiry
HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Noctone

CAS No.: 66357-59-3

Content: 99.00%

Inquiry
Xian ZB Biotech Co.,Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of Herb Extracts,Cosmetic raw materails,API

Ranitidine Hydrochloride

CAS No.: 66357-59-3

Grade: Pharmaceutical grade

Content: 0.99%

Inquiry
Nanjing Huaman Import and Exp Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of Propylene glycol

China Supplier Factory Direct Supply High Quality 99% Ranitidine Hydrochloride CAS 66357-59-3

CAS No.: 66357-59-3

Grade: Top Product

Content: 99%

Inquiry