 Home > Encyclopedia > Urapidil

Urapidil

Urapidil structure

CAS No:
34661-75-1
Formula:
C20H29N5O3
Chemical Name:
Urapidil
Synonyms:
2,4(1H,3H)-Pyrimidinedione,6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-;6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione;Urapidil;Ebrantil;BKU;Mediatensyl;B 66256;Eupressyl;Uraprene;NSC 310405;Uropidil
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Urapidil is an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist.

Urapidil is a member of piperazines.|Urapidil has been investigated for the treatment of Hypertension During Pre-Eclampsia.

Urapidil Basic Attributes

Molecular Weight：

387.48

Exact Mass：

387.48

EC Number：

252-130-4

UNII：

A78GF17HJS

NSC Number：

310405

DSSTox ID：

DTXSID9021425

ATC Code：

C02CA06|C - Cardiovascular system

Characteristics

PSA：

68.4

XLogP3：

2.28

Density：

1.3±0.1 g/cm3

Melting Point：

156-158 °C

Boiling Point：

549.0±60.0 °C at 760 mmHg

Flash Point：

285.8±32.9 °C

Refractive Index：

1.622

Toxicity：

LD50 in male mice, rats (mg/kg): 750, 550 orally; 260, 145 i.v. (Koenig)

Safety Information

hazard class code：

22-36/37/38

safety instructions：

RTECS Number：

YQ9862000

Marks：

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 130 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS. (See all compounds classified as Serotonin Receptor Agonists.)|Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS. (See all compounds classified as Adrenergic alpha-1 Receptor Antagonists.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

MeSH Entry Terms：

6-(3-(4-(o-methoxyphenyl)-1-piperazinyl)propylamino)-1,3-dimethyluracil

Urapidil Use and Manufacturing

antihypertensive

Computed Properties

Molecular Weight:387.5
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:387.22703980
Monoisotopic Mass:387.22703980
Topological Polar Surface Area:68.4
Heavy Atom Count:28
Complexity:588
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Extract from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Urapidil
Specifications	API
Manufacturer	HUA-YU (WUXI) Pharmaceutical Co., Ltd.

Urapidil sustained-release tablets
Ingredients	The main ingredient of this product is urapidil, chemical name 6-[[3-[4-(0-methoxyphenyl)-1-piperazinyl]-propyl]-1,3-dimethyluracil
Indication	Not yet clear.
Specifications	30mg
Manufacturer	Xi'an Lijun Pharmaceutical Co.Limited

Urapidil Injection
Ingredients	The main ingredient of this product is urapidil. The auxiliary materials are sodium chloride, hydrochloric acid and sodium hydroxide.
Indication	If the patient is using other antihypertensive drugs, drinking alcohol, or has hypovolemia (such as diarrhea, vomiting), the antihypertensive effect of this product may be enhanced. The simultaneous use of cimetidine may increase the blood concentration of this product by up to 15%.
Specifications	5ml:25mg
Manufacturer	Livzon (GROUP) Pharmaceutical FACTORY

See More Related Drugs

Registered Holders

ERREGIERRE SPA

Italy
Active
HUA-YU (WUXI) Pharmaceutical Co., Ltd.

China
Active
Changzhi Yuanyan Pharmaceutical Technology Co., Ltd.

China
Active

See More Registered Holders

Recommended Suppliers of Urapidil

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Urapidil

CAS No.: 34661-75-1

Content: 99.00%

Inquiry
Hangzhou Dawn Ray Pharmaceutical Co.,Ltd Contact Supplier

CN
5 YRS

Business licensed Certified factory

Manufactory Supplier of D-Biotin,Tobramycin base,L(-)-Carnitine base,Polymyxin B sulfate USP,Kanamycin sulfate monohydrate,Finasteride 99% USP

Urapidil 99%min Pharmaceutical API Hypertension drugs made in china

CAS No.: 34661-75-1

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

high purity hot sale 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil 99% high quality see COA KANBEI

CAS No.: 34661-75-1

Grade: Industrial Grade

Content: 99%

Inquiry
lijunchem Contact Supplier

CN
4 YRS

Business licensed

Trader Supplier of APIS,Cosmetic Raw Materials,Pharmaceutical Intermediates,Active Ingredients

6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil 99.5% White crystalline powder lijun

CAS No.: 34661-75-1

Grade: Pharmaceutical Grade

Content: 99.5%

Inquiry
Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals,CATALYST AND AUXILIARY,FLAVORS AND FRAGRANCES,Chemical Pesticides,ADDITIVE

urapidil 34661-75-1

CAS No.: 34661-75-1

Grade: Pharmaceutical Grade

Content: 99%

Inquiry