Tirofiban hydrochloride monohydrate
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Tirofiban hydrochloride monohydrate
structure -
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CAS No:
150915-40-5
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Formula:
C22H36N2O5S.ClH.H2O
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Chemical Name:
Tirofiban hydrochloride monohydrate
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Synonyms:
L-Tyrosine,N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-,hydrochloride,hydrate (1:1:1);L-Tyrosine,N-(butylsulfonyl)-O-[4-(4-piperidinyl)butyl]-,monohydrochloride,monohydrate;Tirofiban hydrochloride monohydrate
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Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs
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CAS No:
Description
White SolidTirofiban is an anti-angina drug, it is successfully developed by the United States Merck company , Patent Number is EP 478363, and in 1998 it was sold in the United States, the trade name is Aggrastat,it is clinically used in treating acute coronary syndromes, including unstable angina or non-Q-wave myocardial infarction, and percutaneous transluminal coronary angioplasty (PTCA) or atherosclerotic plaque excision patients with in combination with heparin.
Tirofiban hydrochloride is a hydrochloride. It contains a tirofiban.|Tirofiban Hydrochloride is the hydrochloride salt form of tirofiban, a non-peptide tyrosine derivative with anticoagulant property. Tirofiban antagonizes fibrinogen binding to the platelet cell surface receptor, glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. The antagonism prevents adenylyl cyclase activation, which mediated via GP IIb/IIIa receptor complex, and results in decreased levels of cAMP and thereby interferes with platelet membrane function and subsequent platelet-platelet interaction, release of platelet granule constituents and prolongation of bleeding time.|Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in the treatment of ACUTE CORONARY SYNDROME.
Tirofiban hydrochloride monohydrate Basic Attributes
495.07
494.221741
1312995-182-4
6H925F8O5J
DTXSID5048635
C47759
Characteristics
114
5.48870
White Solid
131-132 °C
611.7ºC at 760 mmHg
323.7ºC
DMSO: >12mg/mL at warmed to 60°C
-20°C Freezer
Safety Information
NONH for all modes of transport
3
36/37/38
26-37-45
Xi
P261-P305 + P351 + P338
H315-H319-H335
|Danger|H302 (45.45%): Harmful if swallowed [Warning Acute toxicity, oral]|P260, P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P314, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 77 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN. (See all compounds classified as Fibrinolytic Agents.)|Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (See all compounds classified as Platelet Aggregation Inhibitors.)
Aggrastat
Tirofiban hydrochloride monohydrate Use and Manufacturing
Tirofiban is a specific nonpeptide platelet fibrinogen receptor (GPIIb/IIIa) antagonist. Tirofiban is an antithrombotic used in the treatment of unstable angina.
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:495.1
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:14
Exact Mass:494.2217358
Monoisotopic Mass:494.2217358
Topological Polar Surface Area:114
Heavy Atom Count:32
Complexity:579
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Unspecified
Registered Holders
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FARMABIOS S.P.A.
Active
Italy
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Chengdu Sino-Strong Pharmaceutical Co., Ltd.
Active
China
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Zhejiang Zhebang Pharmaceutical Co., Ltd.
Active
China
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Tirofiban hydrochloride monohydrate
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