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1,3,5-Triazine-2,4-diamine, 6-(2,5-dichlorophenyl)-, (2Z)-2-butenedioate (1:1)

1,3,5-Triazine-2,4-diamine, 6-(2,5-dichlorophenyl)-, (2Z)-2-butenedioate (1:1) structure

CAS No:
84504-69-8
Formula:
C9H7Cl2N5.C4H4O4
Chemical Name:
1,3,5-Triazine-2,4-diamine, 6-(2,5-dichlorophenyl)-, (2Z)-2-butenedioate (1:1)
Synonyms:
1,3,5-Triazine-2,4-diamine,6-(2,5-dichlorophenyl)-,(2Z)-2-butenedioate (1:1);1,3,5-Triazine-2,4-diamine,6-(2,5-dichlorophenyl)-,(Z)-2-butenedioate (1:1);MN 1695;2,4-Diamino-6-(2,5-dichlorophenyl)-s-triazine maleate;Irsogladine maleate;Gaslon;Gaslon N
Categories:
Active Pharmaceutical Ingredients > Digestive System Drugs

Description

Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.Target: PDE4; mACHRIrsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reduction of angiogenesis in wild-type mice by 21 and 45.3% (P < 0.02, P < 0.001), in tPA-deficient mice by 42.6 and 46% (P < 0.001, P < 0.001), and in uPA-deficient mice by 27.2 and 46% (P < 0.05, p < 0.001), respectively. Irsogladine inhibits bFGF-induced angiogenesis in wild-type, tPA-knockout, and uPA-knockout mice

1,3,5-Triazine-2,4-diamine, 6-(2,5-dichlorophenyl)-, (2Z)-2-butenedioate (1:1) Basic Attributes

Molecular Weight：

372.16

Exact Mass：

371.018799

HScode：

2933699090

Characteristics

PSA：

165

XLogP3：

2.88400

Melting Point：

205 °C (decomp)

Boiling Point：

552.2ºC at 760 mmHg

Flash Point：

287.8ºC

Storage Conditions：

Desiccate at RT

Toxicity：

LD50 in male, female mice, rats (mg/kg): 6035, 5697, 3898, 2917 orally; 2841, 3216, 1600, 1524 s.c.; 775, 1006, 558, 545 i.p. (Ueda, 1984 p 474)

Safety Information

Transport codes：

NONH for all modes of transport

RTECS Number：

XY5930000

Precautionary statement(s)：

P201, P202, P281, P308+P313, P405, P501

Hazard Statements：

H361

1,3,5-Triazine-2,4-diamine, 6-(2,5-dichlorophenyl)-, (2Z)-2-butenedioate (1:1) Use and Manufacturing

antiulcerative;selective PDE4 inhibitor which also enhances gap junction intercellular communication

Recommended Suppliers of 1,3,5-Triazine-2,4-diamine, 6-(2,5-dichlorophenyl)-, (2Z)-2-butenedioate (1:1)

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
YRS

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Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Irsogladine maleate

CAS No.: 84504-69-8

Content: 99.00%

Inquiry
Hangzhou Royalchem Co.,LTD Contact Supplier

CN
YRS

Business licensed

Trader Supplier of Pharmaceutical intermediates

Irsogladine maleate RC09725

Unit Price: nullnull /null null

CAS No.: 84504-69-8

Grade: Pharmaceutical Grade

Content: 99%

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Guide of 1,3,5-Triazine-2,4-diamine, 6-(2,5-dichlorophenyl)-, (2Z)-2-butenedioate (1:1)

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Recommended Suppliers
Learn More Other Chemicals

1,3,5-Triazine-2,4-diamine, 6-(2,5-dichlorophenyl)-, (2Z)-2-butenedioate (1:1)

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