1,3,5-Triazine-2,4-diamine, 6-(2,5-dichlorophenyl)-, (2Z)-2-butenedioate (1:1)
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1,3,5-Triazine-2,4-diamine, 6-(2,5-dichlorophenyl)-, (2Z)-2-butenedioate (1:1)
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CAS No:
84504-69-8
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Formula:
C9H7Cl2N5.C4H4O4
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Chemical Name:
1,3,5-Triazine-2,4-diamine, 6-(2,5-dichlorophenyl)-, (2Z)-2-butenedioate (1:1)
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Synonyms:
1,3,5-Triazine-2,4-diamine,6-(2,5-dichlorophenyl)-,(2Z)-2-butenedioate (1:1);1,3,5-Triazine-2,4-diamine,6-(2,5-dichlorophenyl)-,(Z)-2-butenedioate (1:1);MN 1695;2,4-Diamino-6-(2,5-dichlorophenyl)-s-triazine maleate;Irsogladine maleate;Gaslon;Gaslon N
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CAS No:
Description
Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.Target: PDE4; mACHRIrsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reduction of angiogenesis in wild-type mice by 21 and 45.3% (P < 0.02, P < 0.001), in tPA-deficient mice by 42.6 and 46% (P < 0.001, P < 0.001), and in uPA-deficient mice by 27.2 and 46% (P < 0.05, p < 0.001), respectively. Irsogladine inhibits bFGF-induced angiogenesis in wild-type, tPA-knockout, and uPA-knockout mice
1,3,5-Triazine-2,4-diamine, 6-(2,5-dichlorophenyl)-, (2Z)-2-butenedioate (1:1) Basic Attributes
372.16
371.018799
2933699090
Characteristics
165
2.88400
205 °C (decomp)
552.2ºC at 760 mmHg
287.8ºC
Desiccate at RT
LD50 in male, female mice, rats (mg/kg): 6035, 5697, 3898, 2917 orally; 2841, 3216, 1600, 1524 s.c.; 775, 1006, 558, 545 i.p. (Ueda, 1984 p 474)
Safety Information
NONH for all modes of transport
XY5930000
P201, P202, P281, P308+P313, P405, P501
H361
1,3,5-Triazine-2,4-diamine, 6-(2,5-dichlorophenyl)-, (2Z)-2-butenedioate (1:1) Use and Manufacturing
antiulcerative;selective PDE4 inhibitor which also enhances gap junction intercellular communication
Drug Function and Efficacy
It has anti-ulcer effect, can strengthen the combination between gastric mucosal epithelial cells, enhance the stability of the mucosa itself, play a cellular defense role, and increase the blood flow of gastric mucosa; it does not affect the basic gastric acid secretion, and does not stimulate acid secretion. It shows the inhibitory or curative effect of dosage compliance on experimental gastritis.
Registered Holders
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Zhejiang Haizhou Pharmaceutical Co., Ltd.
Active
China
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Jiangxi Pharmaceutical Co., Ltd.
Active
China
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Qilu Pharmaceutical Co., Ltd.
Active
China
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1,3,5-Triazine-2,4-diamine, 6-(2,5-dichlorophenyl)-, (2Z)-2-butenedioate (1:1)
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