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(±)-Dropropizine

(±)-Dropropizine structure

CAS No:
17692-31-8
Formula:
C13H20N2O2
Chemical Name:
(±)-Dropropizine
Synonyms:
1,2-Propanediol,3-(4-phenyl-1-piperazinyl)-;3-(4-Phenyl-1-piperazinyl)-1,2-propanediol;Dropropizine;Dopropizin;Larylin;Catabex;Katril;Ribex;Tussilex;U.C.B. 1967;Ditustat;(±)-Dropropizine;117067-01-3
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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Description

Dropropizine is a racemic non-opiate antitussive agent which has been used clinically for many years.

3-(4-phenyl-1-piperazinyl)propane-1,2-diol is a member of piperazines.

(±)-Dropropizine Basic Attributes

Molecular Weight：

236.31

Exact Mass：

236.31

EC Number：

241-683-7

NSC Number：

757820

DSSTox ID：

DTXSID0045624

ATC Code：

R - Respiratory system

HScode：

2933599090

Characteristics

PSA：

46.9

XLogP3：

0.6

Appearance：

white or almost white powder

Density：

1.168±0.06 g/cm3(Predicted)

Melting Point：

105 °C

Boiling Point：

205 °C @ Press: 1 Torr

Flash Point：

220.9±24.3 °C

Refractive Index：

1.577

Water Solubility：

>35.4 [ug/mL]

Vapor Pressure：

1.5E-07mmHg at 25°C

Toxicity：

LD50 in rats (mg/kg): 200 i.v., 750 orally (Morren)

Collision Cross Section：

155.7 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

RTECS Number：

TZ1074800

Marks：

Stability/Shelf Life：

Stable at normal temperatures and pressures.

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 43 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally. (See all compounds classified as Antitussive Agents.)

MeSH Entry Terms：

DF 526

(±)-Dropropizine Use and Manufacturing

Dropropizine is a cough suppressant and central sedative therapeutic agent.

Computed Properties

Molecular Weight:236.31
XLogP3:0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:236.152477885
Monoisotopic Mass:236.152477885
Topological Polar Surface Area:46.9
Heavy Atom Count:17
Complexity:212
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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