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Gabexate mesilate

Gabexate mesilate structure

CAS No:
56974-61-9
Formula:
C16H23N3O4.CH4O3S
Chemical Name:
Gabexate mesilate
Synonyms:
Benzoic acid,4-[[6-[(aminoiminomethyl)amino]-1-oxohexyl]oxy]-,ethyl ester,methanesulfonate (1:1);Benzoic acid,4-[[6-[(aminoiminomethyl)amino]-1-oxohexyl]oxy]-,ethyl ester,monomethanesulfonate;FOY;Gabexate mesilate;Gabexate mesylate;FOY-S 983;Mesyl gabexate;FOY 007;Megacert;Gabexate monomethanesulfonate;Arodate;Reminaron;101963-28-4
Categories:
Active Pharmaceutical Ingredients > Digestive System Drugs

Description

Gabexate Mesylate is a Factor X inhibitor; serine protease inhibitor .Target: Factor XGabexate mesylate is a non-antigenic synthetic inhibitor of trypsin-like serine proteinases that is therapeutically used in the treatment of pancreatitis and disseminated intravascular coagulation and as a regional anticoagulant for hemodialysis. Values of the inhibition constant (K(i)) for gabexate mesylate binding to human and bovine tryptase were 3.4 x 10(-9) M and 1.8 x 10(-7) M (at pH 7.4 and 37.0

Gabexate mesilate Basic Attributes

Molecular Weight：

417.48

Exact Mass：

417.156982

EC Number：

1312995-182-4

HScode：

29252900

Characteristics

PSA：

180

XLogP3：

3.58790

Appearance：

solid

Melting Point：

89.0 to 93.0 °C

Boiling Point：

508.6ºC at 760 mmHg

Flash Point：

261.4ºC

Toxicity：

LD50 in mice (mg/kg): 8000 orally; 4700 s.c.; 25 i.v. (Fujita)

Safety Information

Transport codes：

3077

wgk germany：

RTECS Number：

DG2800800

Marks：

Gabexate mesilate Use and Manufacturing

Pancreatitis;Serine protease inhibitor

Drug Function and Efficacy

The specific pharmacological effects cannot be determined from the above information, please refer to the detailed instructions.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Gabexate Mesylate for Injection
Specifications	0.1g

Gabexate mesylate

Gabexate Mesylate for Injection
Ingredients	Gabexate mesylate
Indication	This experiment has not been conducted and there are no reliable references.

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Registered Holders

桂化学株式会社

Japan
Active
Chongqing Pharscin Pharmaceutical Co., Ltd.

China
Active
Sichuan Tiandao Pharmaceutical Co., Ltd.

China
Active

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