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Escitalopram oxalate

Escitalopram oxalate structure

CAS No:
219861-08-2
Formula:
C20H21FN2O.C2H2O4
Chemical Name:
Escitalopram oxalate
Synonyms:
5-Isobenzofurancarbonitrile,1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-,(1S)-,ethanedioate (1:1);Escitalopram oxalate;Lu 26-054-0;Lexapro;Cipralex;(+)-(S)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile oxalate (1:1);(S)-(+)Citalopram oxalate;Cipra-Pro;Szetalo
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Escitalopram is a selective serotonin reuptake inhibitor (SSRI) with Ki of 0.89 nM.Target: SSRIsEscitalopram, the S-enantiomer of citalopram, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). Escitalopram may be used to treat major depressive disorder (MDD) and generalized anxiety disorder (GAD). Escitalopram has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (

Escitalopram Oxalate is the oxalate salt of escitalopram, a pure S-enantiomer of the racemic bicyclic phthalane derivative citalopram, with antidepressant activity. As a selective serotonin reuptake inhibitor (SSRI), escitalopram blocks the reuptake of serotonin by neurons in the central nervous system (CNS), thereby potentiating CNS serotonergic activity.|A furancarbonitrile that is one of the serotonin uptake inhibitors used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from TARDIVE DYSKINESIA in preference to tricyclic antidepressants, which aggravate dyskinesia.

Escitalopram oxalate Basic Attributes

Molecular Weight：

414.43

Exact Mass：

414.159088

EC Number：

1806241-263-5

UNII：

5U85DBW7LO

NSC Number：

758934

DSSTox ID：

DTXSID1046003

NCI Thesaurus Code：

C47518

HScode：

29322090

Characteristics

PSA：

111

XLogP3：

2.96858

Appearance：

white solid

Melting Point：

144-146 °C

Boiling Point：

428.3ºC at 760 mmHg

Flash Point：

212.8ºC

Water Solubility：

DMSO: ≥15mg/mL

Storage Conditions：

-20°C Freezer, Under Inert Atmosphere

Specific rotation：

D +12.31° (c = 1 in methanol)

Collision Cross Section：

178.8 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36

RTECS Number：

NP6333500

Marks：

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (13.64%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 66 companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake. (See all compounds classified as Antidepressive Agents, Second-Generation.)|Compounds that specifically inhibit the reuptake of serotonin in the brain. (See all compounds classified as Serotonin Uptake Inhibitors.)

MeSH Entry Terms：

Celexa

Escitalopram oxalate Use and Manufacturing

Uses

antineoplastic

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:414.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:6
Exact Mass:414.15910000
Monoisotopic Mass:414.15910000
Topological Polar Surface Area:111
Heavy Atom Count:30
Complexity:537
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Escitalopram is the mono-S-enantiomer of the dicyclic hydrogenated phthalide derivative citalopram. Its antidepressant effect may be related to inhibiting the reuptake of 5-HT by central nervous system neurons, thereby enhancing the function of central serotonergic nerves. It is a highly selective 5-HT reuptake inhibitor (SSRI) with little effect on the reuptake of norepinephrine and dopamine. Escitalopram has no affinity or only low affinity for multiple receptors, and has no affinity or only low affinity for Na, K, Cl-, and Ca2 channels.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Escitalopram Oxalate Tablets
Ingredients	Active ingredient: Escitalopram oxalate. Chemical name: S()-1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-nitrile oxalate Molecular weight: C20H21FN2O·C2H2O4
Indication	Contraindications to concomitant use: Non-selective MAOIs Serious adverse reactions have been reported in patients receiving SSRIs who have been treated with non-selective monoamine oxidase inhibitors (MAOIs) concomitantly and in patients who have recently discontinued SSRI treatment and started MAOI treatment. Some patients have developed serotonin syndrome. Escitalopram oxalate is contraindicated for concomitant use with non-selective MAOIs. Lexapro may be started at least 14 days after discontinuation of irreversible MAOI treatment and at least 1 day after reversible MAOIs (e.g., moclobemide). Non-selective MAOIs may be started at least 7 days after discontinuation of Lexapro. Concomitant therapy not recommended: Reversible, selective MAO-A inhibitors (moclobemide). Due to the risk of serotonin syndrome,
Specifications	5mg
Manufacturer	Zhejiang Jinhua Conba BIO-PHARM. Co., Ltd.

Escitalopram Oxalate Tablets
Ingredients	Active ingredient: Escitalopram oxalate. Chemical name: S()-1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-nitrile oxalate Molecular weight: C20H21FN2O·C2H2O4
Indication	Pharmacodynamic interactions Contraindications for concomitant use: Non-selective MAOIs, irreversible AOIs There have been reports of serious adverse reactions in patients receiving SSRIs who were treated with non-selective monoamine oxidase inhibitors (MAOIs) and in patients who recently discontinued SSRIs and started MAOI treatment. Some patients developed serotonin syndrome. This product is contraindicated for use with non-selective MAOIs. Treatment with this product can be started at least 14 days after stopping irreversible MAOI treatment and at least 1 day after reversible MAOIs such as moclobemide. Non-selective MAOI treatment can be started at least 7 days after stopping treatment with this product. Pimozide Patients treated with this product 40 mg per day and taking a single dose of pimozide 2 mg at the same time can result in a decrease in the pimozide AUC
Specifications	10mg
Manufacturer	Zhejiang Jinhua Conba BIO-PHARM. Co., Ltd.

Escitalopram Oxalate Tablets
Specifications	5 mg

See More Related Drugs

Registered Holders

MAITHRI LABORATORIES PRIVATE LTD

United States
Active
RAKS PHARMA PVT LTD

United States
Active
VIRUPAKSHA ORGANICS LTD

United States
Active

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