Bifendate
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Bifendate
structure -
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CAS No:
73536-69-3
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Formula:
C20H18O10
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Chemical Name:
Bifendate
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Synonyms:
[4,4′-Bi-1,3-benzodioxole]-5,5′-dicarboxylic acid,7,7′-dimethoxy-,5,5′-dimethyl ester;[4,4′-Bi-1,3-benzodioxole]-5,5′-dicarboxylic acid,7,7′-dimethoxy-,dimethyl ester;Bifendate;DDB;Dimethyl 4,4′-dimethoxy-5,6,5′,6′-di(methylenedioxy)biphenyl-2,2′-dicarboxylate;DDB (pharmaceutical);α-DDB;Dimethyl dicarboxylate biphenyl;Diphenyl dimethyl bicarboxylate;Bifendatatum;111897-19-9;80944-39-4
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CAS No:
Drug Information
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)|Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 ENZYMES. (See all compounds classified as Cytochrome P-450 Enzyme Inhibitors.)|Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)
Bifendate has known human metabolites that include Mono-O-demethylated bdd and methyl 4-(2,3-dihydroxy-4-methoxy-6-methoxycarbonylphenyl)-7-methoxy-1,3-benzodioxole-5-carboxylate.
7,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester
Bifendate Use and Manufacturing
Bifendate is a synthetic intermediate of Schisandrin C and also a anti-HBV drug used in the treatment of chronic hepatitis B.
Computed Properties
Molecular Weight:418.3
XLogP3:2.8
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:7
Exact Mass:418.08999677
Monoisotopic Mass:418.08999677
Topological Polar Surface Area:108
Heavy Atom Count:30
Complexity:587
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
This product is an intermediate in the synthesis of Schisandrae Chinensis A, which can reduce liver damage and alanine aminotransferase (ALT) elevation caused by carbon tetrachloride; inhibit liver microsomal lipid peroxidation caused by carbon tetrachloride, carbon tetrachloride metabolic conversion to carbon monoxide, and reduce the consumption of reduced coenzyme II and oxygen in the process of carbon tetrachloride metabolism, thereby protecting the structure and function of liver cell biomembrane; reduce the increase of liver ALT induced by prednisone, and promote liver regeneration in mice with partial hepatectomy; have a significant induction effect on cytochrome P450 enzyme activity, enhance the detoxification ability of carbon tetrachloride and certain carcinogens; improve protein metabolism in some hepatitis patients, increase albumin and reduce globulin. However, it has no negative conversion effect on HbsAg and HbeAg, and cannot shrink enlarged liver and spleen.
Registered Holders
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Jiangsu Hengfeng Pharmaceutical Co., Ltd.
Active
China
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Beijing Xiehe Pharmaceutical Co., Ltd.
Active
China
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Wanbangde Pharmaceutical Group Co., Ltd.
Active
China
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