Dimethylformamide
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Dimethylformamide
structure -
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CAS No:
68-12-2
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Formula:
C3H7NO
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Chemical Name:
Dimethylformamide
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Synonyms:
Formamide,N,N-dimethyl-;N,N-Dimethylformamide;Dimethylformamide;DMF;N-Formyldimethylamine;DMFA;DMF (amide);N,N-Dimethylmethanamide;N,N-Dimethylformaldehyde;Virodene-P 058;NSC 5356;D 165635;114057-15-7;15175-63-0;15175-77-6;33513-42-7
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CAS No:
Description
N,N-Dimethylformamide is a colorless or slightly yellow liquid with a boiling point of 153°C and a vapor pressure of 380 Pa at 20°C. It is freely soluble in water and soluble in alcohols, acetone and benzene. N,N-Dimethylformamide is used as solvent, catalyst and gas absorbent. React violently with concentrated sulfuric acid, fuming nitric acid and can even explode. Pure Dimethylformamide is odorless, but industrial grade or modified Dimethylformamide has a fishy smell because it contains impur
Dimethylformamide is an organic compound with the formula (CH3)2NC(O)H. Commonly abbreviated as DMF (although this acronym is sometimes used for dimethylfuran, or dimethyl fumarate), this colourless liquid is miscible with water and the majority of organic liquids. DMF is a common solvent for chemical reactions. Dimethylformamide is odorless whereas technical grade or degraded samples often have a fishy smell due to impurity of dimethylamine. As its name indicates, it is a derivative of formamide, the amide of formic acid. DMF is a polar (hydrophilic) aprotic solvent with a high boiling point. It facilitates reactions that follow polar mechanisms, such as SN2 reactions.
Characteristics
20.31000
0.3403
Transparent colorless liquid
0.9445 g/cm3 @ Temp: 25 °C
-61 °C
153 °C @ Press: 760 Torr
136 °F
n20/D 1.430(lit.)
H2O: soluble
Packing intact、handling with care,Warehouse ventilation、Keep away from open flames、 high temperature、Separate storage with oxidant and acid
2.7 mm Hg ( 20 °C)
2.5 (vs air)
LD50 in mice, rats (ml/kg): 6.8, 7.6 orally; 6.2, 4.7 i.p. (Bartsch)
Class II Combustible Liquid: Fl.P. at or above 100°F and below 140°F.
Explosion hazard when exposed to flame.
Fishy odor
pH = 6.7 (0.5 molar solution in water)
Safety Information
III
3
UN 2265 3/PG 3
1
R20/21; R36; R61
S53-S45
LQ2100000
T
Separated from incompatible materials. See Chemical Dangers.
DMF is stable. It is hygroscopic and easily absorbs water form a humid atmosphere and should therefore be kept under dry nitrogen. High purity DMF, required for acrylic fibers, is best stored in aluminum tanks. DMF dose not change under light or oxygen and does not polymerize spontaneously. Temperatures >350 deg C may cause decomposition to form dimethylamine and carbon dioxide, with pressure developing in closed containers.
P201-P280-P305 + P351 + P338-P308 + P313
H226-H312 + H332-H319-H360D
UN 2265
P201; P210; P261; P280; P308 + P313; P370 + P378
Dimethylformamide Use and Manufacturing
Dimethylformamide is an organic compound with the formula (CH3)2NC(O)H. Commonly abbreviated as DMF (although this acronym is sometimes used for dimethylfuran, or dimethyl fumarate), this colourless liquid is miscible with water and the majority of organic liquids. DMF is a common solvent for chemical reactions. Dimethylformamide is odorless whereas technical grade or degraded samples often have a fishy smell due to impurity of dimethylamine. As its name indicates, it is a derivative of formamide, the amide of formic acid. DMF is a polar (hydrophilic) aprotic solvent with a high boiling point. It facilitates reactions that follow polar mechanisms, such as SN2 reactions.
Computed Properties
Molecular Weight:73.09
XLogP3:-1
Hydrogen Bond Acceptor Count:1
Exact Mass:73.052763847
Monoisotopic Mass:73.052763847
Topological Polar Surface Area:20.3
Heavy Atom Count:5
Complexity:33.9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Price Analysis
- Data: 2026-07-24
- Price: 4420.00Yuan/mt
- Change: 0
Drug Function and Efficacy
This product is an antiviral drug that has an inhibitory effect on herpes simplex type I or type II virus and varicella zoster virus. Its mechanism of action is to inhibit the early synthesis of viral DNA (deoxyribonucleic acid) and protein. In addition, this product has good antifungal and antipruritic effects.
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