2-Methoxy-4-pyridinecarboxylic acid
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2-Methoxy-4-pyridinecarboxylic acid
structure -
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CAS No:
105596-63-2
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Formula:
C7H7NO3
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Chemical Name:
2-Methoxy-4-pyridinecarboxylic acid
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Synonyms:
2-METHOXYISONICOTINIC ACID;2-METHOXYPYRIDINE-4-CARBOXYLIC ACID;2-METHOXY-4-PYRIDINECARBOXYLIC ACID;2-METHOXYISONICOTONIC ACID;4-Pyridinecarboxylicacid,2-methoxy-(9CI);4-METHOXY-4-PYRIDINECARBOXYLIC ACID;Zinc00336011;2-methoxy-4-picolinic acid
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CAS No:
Characteristics
59.4
0.9
White to pale brown Solid or Crystalline Powder
1.284±0.06 g/cm3(Predicted)
197-200°C
383.0±22.0 °C(Predicted)
185.4±22.3 °C
1.550
1.5E-06mmHg at 25°C
Safety Information
IRRITANT
NONH for all modes of transport
3
36/37/38-36
26-36/37/39
Xi
Irritant
P305 + P351 + P338
H319
|Warning|H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]|P264, P280, P305+P351+P338, and P337+P313|Aggregated GHS information provided by 41 companies from 3 notifications to the ECHA C&L Inventory.
2-Methoxy-4-pyridinecarboxylic acid Use and Manufacturing
To a suspension of the title compound of Preparation 22 (1.94 g, 6.49 mmol) in acetonitrile (150 mL), sodium iodide (4.90 g, 32.69 mmol) and trimethylsilyl chloride (4.10 mL, 32.42 mmol) were added. The resulting suspension was stirred under nitrogen atmosphere at 40General procedure: The corresponding dianiline (1 eq.), the corresponding aromatic acid (1.1 eq.), HATU (1.1 eq.) and N, N-diisopropyl-ethylamine (2 eq.) in dichloromethane (2 mL/g) was stirred overnight at room temperature. The product was isolated as per specification.To a solution of 2- methoxyisonicotinic acid (50.0 g, 326.0 mmol) in DMF (1.0 L) was added N.O- dimethylhydroxylamine hydrochloride (63.8 g, 654.0 mmol), AAV-d i i s o p ro p y 1 c th y 1 am i n c (21 1.0 g, 1630 mmol) and HATU (248.0 g, 653.0 mmol). The resulting mixture was stirred at room temperature for 2 h. General Work-up Procedure 1 was followed. The residue was purified by Chromatography A to afford A/ 2-dimethoxy-A-methyl isonicotinamide (58.3 g, 91%) as a yellow oil.
Computed Properties
Molecular Weight:153.14
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:153.042593085
Monoisotopic Mass:153.042593085
Topological Polar Surface Area:59.4
Heavy Atom Count:11
Complexity:149
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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2-Methoxy-4-pyridinecarboxylic acid
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