2-Chloro-6-hydroxynicotinic acid
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2-Chloro-6-hydroxynicotinic acid
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CAS No:
38025-90-0
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Formula:
C6H4ClNO3
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Chemical Name:
2-Chloro-6-hydroxynicotinic acid
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Synonyms:
2-Chloro-6-Hydroxynicotinic Acid;2-CHLORO-6-HYDROXYNICOTINIC ACID,98%;2-Chloro-6-hydroxy-3-pyridinecarboxylic Acid;2-Chloro-6-hydroxypyridine-3-carboxylic acid
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CAS No:
Safety Information
IRRITANT
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, P501
H302+H312+H332
|Warning|H302+H312+H332 (50%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2-Chloro-6-hydroxynicotinic acid Use and Manufacturing
Step a 2-chloro-6-oxo-1 , 6-dιhydropyrιdιne-3-carboxylιc acιd; ° A 500-mL round-bottom flask was charged with 2, 6-dιchloronιcotιnιc acid (25 0 g 130 mmol), NaOH solution (325 ml_, 2N) and the solution was refluxed at 1292, 6-Dichloronicotinic acid (6 g) was placed in a 250 mL round bottom flask, and sodium hydroxide solution (80 mL) was added.The mixture was heated to 120 ° C for 4 hours. After the reaction was completed, it was cooled to room temperature, acidified with 6N hydrochloric acid, and the solid was precipitated, filtered, and dried to give the title compound (4 g).Step a 2-chloro-6-oxo-1 , 6-dιhydropyrιdιne-3-carboxylιc acιd; ° A 500-mL round-bottom flask was charged with 2, 6-dιchloronιcotιnιc acid (25 0 g 130 mmol), NaOH solution (325 ml_, 2N) and the solution was refluxed at 1292, 6-Dichloronicotinic acid (6 g) was placed in a 250 mL round bottom flask, and sodium hydroxide solution (80 mL) was added.The mixture was heated to 120 ° C for 4 hours. After the reaction was completed, it was cooled to room temperature, acidified with 6N hydrochloric acid, and the solid was precipitated, filtered, and dried to give the title compound (4 g).
Computed Properties
Molecular Weight:173.55
XLogP3:0.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:172.9879707
Monoisotopic Mass:172.9879707
Topological Polar Surface Area:66.4
Heavy Atom Count:11
Complexity:280
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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2-Chloro-6-hydroxynicotinic acid
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