2-Pyridinamine, 6-chloro-5-methyl
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2-Pyridinamine, 6-chloro-5-methyl
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CAS No:
442129-37-5
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Formula:
C6H7ClN2
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Chemical Name:
2-Pyridinamine, 6-chloro-5-methyl
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Synonyms:
2-Pyridinamine, 6-chloro-5-methyl;2-Pyridinamine,6-chloro-5-methyl-(9CI);6-Chloro-5-methyl-2-pyridinamine;6-chloro-5-methylpyridin-2-amine;6-Chloro-5-Methyl-pyridin-2-ylaMine;6-AMino-2-chloro-3-Methylpyridine;EOS-61005
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CAS No:
2-Pyridinamine, 6-chloro-5-methyl Use and Manufacturing
II-1 (2.26 g, 10 mmol), methanol (20 ml), concentrated hydrochloric acid (1 eq) was placed in a 50 ml reaction flask.Heat to 70 °C for 1 hour, concentrate, add 10 ml of water, The pH of the system was adjusted to neutral with sodium hydroxide, and filtered to obtain a product of 1.2 g.The yield is 85percent.Step d: 6-Chloro-5-methyl-pyridin-2-ylamine; To N-(6-chloro-5-methyl-pyridin-2-yl)- 2, 2-dimethyl-propionamide (4.00 g, 17.7 mmol) was added 6 ν HCl (20 mL) at room temperature. The mixture was stirred at 80 To a stirred solution of 2-chloro-3-methyl pyridine-1-oxide (9g) and pyridine (1 9. 9mL) in acetonitrile (9OmL) at about 65°C, was added a solution of trifluoroacetic anhydride (19. 53g in acetonitrile (1 8mL). The reaction mixture was stirred for about ih at about70°C. The reaction mixture was allowed to cool to about 10°C to about 15°C and ethanolamine (37. 82g) was added to it, The reaction mixture was maintained for about I 2h at about room temperature and water and ethyl acetate were added to it. The two layers were separated and the organic layer was washed with water and saturated brine solution, dried and concentrated under reduced pressure at about 45°C. The residue waspurified by column chromatography (20-25percent ethyl acetate in hexane). Yield: 4.1 g (44percent).‘H NIVIR (300IVIHz, CDC13): ö 7.29-7.26 (d, J7.8Hz, 1H), 6.37-6.34 (d, J8.lHz, 1H), 4.22(brs, 2H), 2.22 (s, 3H)Mass [M+Hfb: 142.58
Computed Properties
Molecular Weight:142.58
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:142.0297759
Monoisotopic Mass:142.0297759
Topological Polar Surface Area:38.9
Heavy Atom Count:9
Complexity:97.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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