6-METHYL-2,3-PYRIDINEDICARBOXYLIC ACID

6-methyl-2, 3-PYRIDINEDICARBOXYLIC acid (5.1 g, 0.03 mol) was dissolved in MEOH (80 ml) and the pH was adjusted to 2 with HCI/isopropanol 6N. This mixture was heated at reflux for 16 hrs. After evaporating MEOH, the residue was co-evaporated two times with toluene and dried in a vacuum oven to get a yellow solid (5. 81g, 98.7%). MS: [M+H] +=210In a 100 ml round-bottomed flask Preparation 2 2-Methyl-furo[3, 4-b]pyridine-5, 7-dione A solution of 6-methyl-1, 2-pyridine dicarboxylic acid (25 g, 138 mmol) and acetic acid (42 mL, 733 mmol) in DME (150 mL) is treated with pyridine (22 mL, 272 mmol) and stirred at room temperature for 2 h. The pale yellow solution is diluted with ether (250 mL) and then hexane (1250 mL) is added slowly. A white precipitate is formed. The solution is cooled to 0 C. for 30 min and the white solid is collected by filtration. The solid is washed with hexane and dried to give the title compound as a white solid (16.7 g, 74%).A mixture of In a 100 ml round-bottomed flask in a 100 ml round-bottomed flask Description 23: 2-methylfuro[3, 4-b]pyridine-5, 7-dione (D23); In a 100 ml round-bottomed flask In a 100 ml round-bottomed flask In a 100 ml round-bottomed flask In a 100 ml round-bottomed flask (5.50 g, 30.36 mmol) was dissolved in Acetic anhydride (14.3 ml_) and the mixture heated at 100 C under nitrogen for 5 hours. Volatiles were removed under vacuum to give 2-methyl-5H, 7H-furo[3, 4-b]pyridine-5, 7- dione (Int. a, 4.97 g).

Molecular Weight:181.15
XLogP3:0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:181.03750770
Monoisotopic Mass:181.03750770
Topological Polar Surface Area:87.5
Heavy Atom Count:13
Complexity:228
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes