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6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride structure

CAS No:
84163-13-3
Formula:
C12H13FN2O.ClH
Chemical Name:
6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride
Synonyms:
1,2-Benzisoxazole,6-fluoro-3-(4-piperidinyl)-,hydrochloride (1:1);1,2-Benzisoxazole,6-fluoro-3-(4-piperidinyl)-,monohydrochloride;4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidine hydrochloride;6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride;6-Fluoro-3-(4-piperidinyl)benzisoxazole hydrochloride;6-Fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride;6-Fluoro-3-(piperidinyl-4-yl)-benzisoxazole hydrochloride;6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole monohydrochloride
Categories:
Pharmaceutical Intermediates > Antipsychotics

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6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Basic Attributes

Molecular Weight：

256.7

Exact Mass：

256.077881

EC Number：

1806241-263-5

HScode：

2934999090

Characteristics

PSA：

38.1

XLogP3：

3.56470

Appearance：

White powder

Melting Point：

293-295 °C

Boiling Point：

387.3ºC at 760 mmHg

Flash Point：

188ºC

Safety Information

Hazard category：

IRRITANT

Transport codes：

NONH for all modes of transport

Marks：

Precautionary statement(s)：

P261, P264, P270, P271, P273, P280, P301+P310, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P391, P403+P233, P405, P501

Hazard Statements：

H301

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Use and Manufacturing

Methods of Manufacturing

Potassium hydroxide (27 g) was added to 600 mL of methanol and added(2, 4-difluorophenyl) - (4-piperidinyl) methanone oxime hydrochloride (55 g)Heating reaction for about 2.5 hours. Cold to room temperature, add appropriate amount of anhydrous MgSO4, stirring about 1h. The filtrate was concentrated under reduced pressure. Join500 mL of acetone, stirred at room temperature for about 0.5 h, filtered, the filtrate stirred into the hydrochloric acid to pH = 2 ~ 3, filter, dry, white solidBody 35g. The methanol content is 0.4percent.EXAMPLE 35

Uses

Intermediates of ziprasidone and pipelopirone

Recommended Suppliers of 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

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6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride 99% Pharm Intermediate Professional Producer Greenbo

CAS No.: 84163-13-3

Grade: Pharmaceutical Grade

Content: 99%

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6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

CAS No.: 84163-13-3

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Guide of 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
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6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride

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