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Losartan carboxylic acid

Losartan carboxylic acid structure

CAS No:
124750-92-1
Formula:
C22H21ClN6O2
Chemical Name:
Losartan carboxylic acid
Synonyms:
1H-Imidazole-5-carboxylic acid,2-butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-;1H-Imidazole-5-carboxylic acid,2-butyl-4-chloro-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-;2-Butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid;EXP 3174;E 3174;Losartan carboxylic acid;2-Butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Light-Yellow SolidChEBI: A biphenylyltetrazole that is losartan with the hydroxymethyl group at position 5 on the imidazole ring replaced with a carboxylic acid.

Losartan carboxylic acid is a biphenylyltetrazole that is losartan with the hydroxymethyl group at position 5 on the imidazole ring replaced with a carboxylic acid. It has a role as a metabolite. It is a biphenylyltetrazole, a member of imidazoles and an organochlorine compound. It derives from a losartan.

Losartan carboxylic acid Basic Attributes

Molecular Weight：

436.89

Exact Mass：

436.89

UNII：

GD76OCH73X

DSSTox ID：

DTXSID80154474

HScode：

29339900

Characteristics

PSA：

110

XLogP3：

Appearance：

Light-Yellow Solid

Density：

1.41±0.1 g/cm3(Predicted)

Melting Point：

176-178 °C

Boiling Point：

707.8±70.0 °C(Predicted)

Flash Point：

381.8±35.7 °C

Refractive Index：

1.695

Storage Conditions：

-20°C Freezer

Vapor Pressure：

5.04E-21mmHg at 25°C

Collision Cross Section：

205.08 Å² [M-H]-

Safety Information

safety instructions：

24/25

Drug Information

MeSH：

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

Metabolism/Metabolites：

Losartan carboxylic acid is a known human metabolite of losartan and losartan carboxaldehyde.

MeSH Entry Terms：

1H-imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-((2'-(2H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-

Losartan carboxylic acid Use and Manufacturing

A metabolite of Losartan

Computed Properties

Molecular Weight:436.9
XLogP3:5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:436.1414516
Monoisotopic Mass:436.1414516
Topological Polar Surface Area:110
Heavy Atom Count:31
Complexity:590
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes