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Dapoxetine hydrochloride

Dapoxetine hydrochloride structure

CAS No:
129938-20-1
Formula:
C21H24ClNO
Chemical Name:
Dapoxetine hydrochloride
Synonyms:
DL-Dapoxteine HCL;N,N-DiMethyl-1-phenyl-3-(1-naphthalenyloxy)propanaMinehydrochloride;(S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine hydrochloride;Dapoxetine/Dapoxetine HCl/Dapoxetine hydrochloride;LY-210448 hydrochloride;Priligy;PRILIGY;LY-210448 HYDROCHLORIDE;(S)-N,N-dimethyl-3-
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Off-white CrystPE is the most common form of male sexual dysfunction affecting20-40% of men globally at some point in their lives. Ejaculation is areflex comprising different sensory pathways, motor centers, and nervepathways. This ejaculatory reflex has been shown to be controlledprimarily by serotonin and dopamine. Dapoxetine isa short-acting SSRI. It is differentiated from the existing SSRI treatmentsfor PE by the fact that it can be administered on an as-needed basis. Inheal

Dapoxetine hydrochloride is a white to slightly yellow powder. It is freely soluble in methanol, propylene glycol, some organic solvents (eg. N,N-dimethylformamide) , slightly soluble in ethanol and almost insoluble in water. It is a BCSI class II compound, and poor solubility is a key factor affecting the difference in clinical efficacy. Dapoxetine hydrochloride exists in various crystal forms, the solubility of different crystal forms is quite different, and there is a phenomenon of phase and transformation between crystal forms.

Dapoxetine ((+)-(S)-N,N-dimethyl-(α)-[2(1naphthal enyloxy)ethyl]-benzenemethanamine hydrochloride) possess a similar structure as that of fluoxetine.

Dapoxetine hydrochloride Basic Attributes

Molecular Weight：

341.88

Exact Mass：

341.154633

EC Number：

640-411-8

UNII：

U4OHT63MRI

Color/Form：

white

HScode：

29221990

Characteristics

PSA：

12.5

XLogP3：

5.71360

Appearance：

white

Melting Point：

175-1790C

Boiling Point：

454.4ºC at 760 mmHg

Flash Point：

132.6ºC

Water Solubility：

DMSO: ≥20mg/mL

Storage Conditions：

-20°C Freezer

Vapor Pressure：

1.27E-09mmHg at 25°C

Specific rotation：

D +135.78° (c = 2.18 in methanol)

Critical Temperature & Pressure：

room temp

Safety Information

Transport codes：

UN 3077 9 / PGIII

wgk germany：

hazard class code：

Xn,N

safety instructions：

36-60-61

Marks：

Xn,N

Storage features：

room temperature (desiccate)

Precautionary statement(s)：

P305 + P351 + P338

Hazard Statements：

22-36-50/53

RIDADR：

UN 3077 9 / PGIII

GHS Classification：

|Warning|H302 (97.67%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P273, P280, P301+P312, P305+P351+P338, P330, P337+P313, and P501|Aggregated GHS information provided by 43 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

dapoxetine

Dapoxetine hydrochloride Use and Manufacturing

Dapoxetine impurities are organic synthesis intermediates and pharmaceutical intermediates, which can be used in laboratory research and development processes and chemical and pharmaceutical synthesis processes, and are mainly used as bulk drug dapoxetine hydrochloride intermediates. Dapoxetine hydrochloride intermediate

Dapoxetine hydrochloride is a short-acting novel selective serotonin reuptake inhibitor marketed for the treatment of premature ejaculation in men. Premature ejaculation (PE) is the most common male sexual disorder, estimated to affect up to 30% of men.

Computed Properties

Molecular Weight:341.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:341.1546421
Monoisotopic Mass:341.1546421
Topological Polar Surface Area:12.5
Heavy Atom Count:24
Complexity:337
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

See the instruction manual for details

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Dapoxetine Hydrochloride Tablets (Aitingjiu)
Ingredients	The main ingredient of this product is dapoxetine hydrochloride
Indication	See instructions for details.
Specifications	30 mg (calculated as C21H23NO); 3 tablets/box, 6 tablets/box.
Manufacturer	Yantai Luyin Pharmaceutical Co., Ltd.

Dapoxetine Hydrochloride Tablets
Specifications	60 mg

Dapoxetine Hydrochloride Tablets
Ingredients	Dapoxetine Hydrochloride
Specifications	30 mg x 6 tablets
Manufacturer	Sichuan Kelun Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

MAITHRI DRUGS PRIVATE LTD

United States
Active
Guangzhou Tosun Pharmaceutical Ltd

China
Active
Biobetta Pharmaceuticals (Shanghai) Co., Ltd.

China
Active

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