Sodium nitroprusside dihydrate
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Sodium nitroprusside dihydrate
structure -
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CAS No:
13755-38-9
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Formula:
C5FeN6O.2H2O.2Na
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Chemical Name:
Sodium nitroprusside dihydrate
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Synonyms:
Ferrate(2-),pentakis(cyano-κC)nitrosyl-,sodium,hydrate (1:2:2),(OC-6-22)-;Ferrate(2-),pentacyanonitrosyl-,disodium,dihydrate;Ferrate(2-),pentakis(cyano-C)nitrosyl-,disodium,dihydrate,(OC-6-22)-;Sodium nitroprusside dihydrate;Disodium nitroprusside dihydrate;Disodium pentacyanonitrosylferrate(2-) dihydrate;SNP;15695-00-8
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Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs
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CAS No:
Description
Nitroprusside disodium dihydrate is a potent vasodilator working through releasing NO spontaneously in blood.Target: OthersNitroprusside disodium dihydrate is a potent vasodilator. Sodium nitroprusside has potent vasodilating effects in arterioles and venules. Sodium Nitroprusside breaks down in circulation to release nitric oxide (NO). NO activates guanylate cyclase in vascular smooth muscle and increases intracellular production of cGMP. The end result is vascular smooth muscle relaxat
Sodium nitroprusside dihydrate is a hydrate that is the dihydrate form of sodium nitroprusside. It has a role as a nitric oxide donor and a vasodilator agent. It contains a sodium nitroprusside.|Sodium nitroprusside is a nitrovasodilator that is used intravenously for therapy of severe hypertension, hypertensive emergencies and heart failure. Despite its use for many years, nitroprusside has not been convincingly linked to cases of clinically apparent liver injury.|A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.
Sodium nitroprusside dihydrate Basic Attributes
297.95
297.948975
238-373-9
DTXSID7041126
2837199090
Safety Information
III
6.1
UN 3288 6.1/PG 3
3
25-26/27/28
45-36/37/39-22
LJ8925000
T,T+
P301 + P310
H301
|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 75 companies from 3 notifications to the ECHA C&L Inventory.|H301: Toxic if swallowed [Danger Acute toxicity, oral]
Toxicity
Serum aminotransferase elevations during nitroprusside therapy are uncommon and are more likely attributable to hepatic ischemia due to hypotension, heart failure or anoxia. Nitroprusside has not been convincingly linked to cases of clinically apparent acute liver injury.
Drug Information
Sodium nitroprusside is a nitrovasodilator that is used intravenously for therapy of severe hypertension, hypertensive emergencies and heart failure. Despite its use for many years, nitroprusside has not been convincingly linked to cases of clinically apparent liver injury.
Antihypertensive Agents
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant and Hackh's Chemical Dictionary, 5th ed, p301, p499) (See all compounds classified as Indicators and Reagents.)|A diverse group of agents, with unique chemical structures and biochemical requirements, which generate NITRIC OXIDE. These compounds have been used in the treatment of cardiovascular diseases and the management of acute myocardial infarction, acute and chronic congestive heart failure, and surgical control of blood pressure. (Adv Pharmacol 1995;34:361-81) (See all compounds classified as Nitric Oxide Donors.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)
Cyanonitrosylferrate
Sodium nitroprusside dihydrate Use and Manufacturing
Reagent for the detection of many organic Compounds, e.g., acetone, aldehydes, also of alkali sulfides, zinc, SO2.
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:297.95
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:14
Exact Mass:297.948962
Monoisotopic Mass:297.948962
Topological Polar Surface Area:139
Heavy Atom Count:17
Complexity:119
Covalently-Bonded Unit Count:11
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Sodium nitroprusside is a fast-acting and short-acting vasodilator. It has a direct dilating effect on both arterial and venous smooth muscles, but does not affect the contraction of the uterus, duodenum or myocardium. Vasodilation reduces peripheral vascular resistance, thus having a hypotensive effect. Vasodilation reduces both the preload and afterload of the heart and improves cardiac output, so it is beneficial for heart failure. Reducing afterload can reduce the impedance of the aorta and left ventricle during valvular insufficiency and reduce reflux.
Registered Holders
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MICRO LABS LTD
Active
United States
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EMCURE PHARMACEUTICALS LTD
Active
United States
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ALCHYMARS ICM SM PRIVATE LTD
Active
United States
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