Bupivacaine hydrochloride
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Bupivacaine hydrochloride
structure -
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CAS No:
14252-80-3
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Formula:
C18H28N2O.ClH
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Chemical Name:
Bupivacaine hydrochloride
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Synonyms:
BUPIVACAINE HYDROCHLORIDE;(+,-)-1-butyl-2’,6’-pipecoloxylididemonohydrochloride,monohydrate;Bupivacaine hydrochloride 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide hydrochloride;Bupivacaine Hydrochloride, USP;IN STOCK BUPIVACAINE HYDROCHLORIDE CAS NO.14252-80-3;BUPIVACAINE HYDROCHLORIDE CAS NO.14252-80-3;Local Anesthetic Pharmaceutical Raw Material Bupivacaine HCl CAS 14252-80-3;1-butyl-2’,6’-pipecoloxylididehydrochloride(+-)
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CAS No:
Description
White Solid
ChEBI: Bupivacaine hydrochloride (anhydrous) is a racemate composed of equimolar amounts of dextrobupivacaine hydrochloride and levobupivacaine hydrochloride. The monohydrate form is commonly used as a local anaesthetic. It has a role as an adrenergic antagonist, an amphiphile, an EC 3.1.1.8 (cholinesterase) inhibitor, an EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor and a local anaesthetic. It contains a levobupivacaine hydrochloride (anhydrous), a dextrobupivacaine hydrochloride (anhydrous) and a bupivacaine(1+).
Bupivacaine hydrochloride Basic Attributes
324.89
324.196838
627-065-3
White to Off-White
2933399090
Characteristics
32.3
4.70940
white solid
249-2510C
423.4ºC at 760 mmHg
209.9ºC
soluble in water, freely soluble in alcohol.
Refrigerator
2.24E-07mmHg at 25°C
LD50 in mice (mg/kg): 7.8 i.v., 82 s.c. (Henn, Brattsand)
Thermal decomposition releases toxic nitrogen oxides and hydrogen chloride fumes
Refrigerator
Safety Information
III
6.1(b)
UN 2811 6.1/PG 2
3
T+
22-36/37/39-45
TK6125000
T+
The warehouse is ventilated, low temperature and dry; stored separately from food raw materials
P264, P270, P273, P280, P301+P310, P305+P351+P338, P321, P330, P337+P313, P405, P501
26/27/28
UN 2811 6.1/PG 2
Bupivacaine hydrochloride Use and Manufacturing
Sodium channel blocker, local anesthetic Bupivacaine hydrochloride is an amide-type local anesthetic, generally used for nerve block anesthesia, local infiltration anesthesia and epidural anesthesia. Its mechanism of action is similar to that of amide-type local anesthetics, that is, the drug is first combined with plasma proteins, metabolized by the liver, and then excreted from the urine through the kidneys.
antineoplastic
Bupivacaine Hydrochloride is the salt form of Bupivacaine (B689561); is a sodium channel blocker, local anesthetic.
Drug Function and Efficacy
It is an amide long-acting local anesthetic. Its anesthesia time is 2 to 3 times longer than that of lidocaine hydrochloride, and its diffusion is similar to that of lidocaine hydrochloride. It has little effect on circulation and respiration, is non-irritating to tissues, and does not produce methemoglobin. The usual dosage has no effect on cardiovascular function. A large dosage can cause a decrease in blood pressure and a slow heart rate. It has a significant blocking effect on β-receptors. There is no obvious rapid tolerance. The maternal drug blood concentration is 4 times that of the fetus.
Registered Holders
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DISHMAN CARBOGEN AMCIS LTD
Active
United States
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EXCELLA GMBH AND CO KG
Active
United States
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SOCIETA ITALIANA MEDICINALI SCANDICCI SIMS SRL
Active
United States
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