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Dantrolene sodium

Dantrolene sodium structure

CAS No:
14663-23-1
Formula:
C14H10N4O5.Na
Chemical Name:
Dantrolene sodium
Synonyms:
2,4-Imidazolidinedione,1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-,sodium salt (1:1);Hydantoin,1-[[5-(p-nitrophenyl)furfurylidene]amino]-,sodium salt;2,4-Imidazolidinedione,1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-,sodium salt;F 440;Dantrolene sodium;Dantrium;Sodium dantrolene;Ryanodex
Categories:
Active Pharmaceutical Ingredients > Anesthetic Agents

Description

mp 279-280C 3415821ChEBI: The anhydrous sodium salt of dantrolene.

Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.

Dantrolene sodium Basic Attributes

Molecular Weight：

336.23

Exact Mass：

336.047058

EC Number：

238-706-8

DSSTox ID：

DTXSID4044585

HScode：

2934999090

Characteristics

PSA：

127.05000

XLogP3：

1.71410

Appearance：

COA

Boiling Point：

85°C 4mm

Flash Point：

283.1ºC

Water Solubility：

18.4 [ug/mL]

Storage Conditions：

Store at RT

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

22-24/25

RTECS Number：

MU3875000

Drug Information

MeSH：

A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358) (See all compounds classified as Muscle Relaxants, Central.)

MeSH Entry Terms：

Dantrium

Dantrolene sodium Use and Manufacturing

Uses

Skeletal muscle relaxant;Blocker of Ca2+ release

Use Classification：

Human drugs -> Rare disease (orphan)|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:336.23
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:336.04706368
Monoisotopic Mass:336.04706368
Topological Polar Surface Area:127
Heavy Atom Count:24
Complexity:536
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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Grade: Good Grade

Content: 99%

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