Dantrolene sodium salt 14663-23-1
14663-23-1
QINGDAO
25kg/DRUM
2023-06-14
Dichloromethane,Linocaine hydrochloride
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Product Description
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Seller Information
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DescriptionECHEMI Editorial Referencemp 279-280C 3415821ChEBI: The anhydrous sodium salt of dantrolene.
Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
Dantrolene is an inhibitor of calcium release from the sarcoplasmic reticulum (IC50= 0.3 μM). It binds to sarcoplasmic reticulum vesicles isolated from normal and malignant hyperthermia-susceptible (MHS) pigs with Kdvalues of 0.3 and 0.09 μM, respectively. Dantrolene reduces spontaneous calcium wave frequency and amplitude in the presence of calmodulin in isolated mouse cardiomyocytes with IC50values of 0.42 and 0.19 μM, respectively. It reduces the magnitude of electrically stimulated twitch tensions in isolated rat extensor digitorum longus and soleus muscles (IC50= 3 μg/ml) and MHS pigs (ED50= 0.85 mg/kg). Formulations containing dantrolene have been used in the treatment of malignant hyperthermia.
mp 279-280C 3415821Basic Info-
Product Name:
Dantrolene sodium salt
Other Name:Dantrolene Sodium Salt;1-[[5-(p-Nitrophenyl)furfurylidene]amino]-hydantoin sodium salt anhydrous;DantroloneSodium;SODIUM DANTROLENE;1-[[[5-(4-NITROPHENYL)-2-FURANYL]METHYLENE]AMINO]-2,4-IMIDAZOLINEDIONE SODIUM SALT;1-[[[5-(4-NITROPHENYL)-2-FURANYL]-METHYLENE]IMINO]2,4-IMIDAZOLIDINEDIONE SODIUM SALT;1-[(5-[P-NITROPHENYL]FURFURYLIDENE)-AMINO]HYDANTOIN SODIUM SALT;DANTRIUM
CAS No.:14663-23-1
Molecular Formula:C14H11N4NaO5
InChIKeys:KSRLIXGNPXAZHD-HAZZGOGXSA-M
Molecular Weight:337.24
Exact Mass:336.047058
EC Number:238-706-8
DSSTox ID:DTXSID4044585
Color/Form:Orange
HScode:2942.00.3500
Categories:
Characteristics-
PSA:
127.05000
XLogP3:1.71410
Appearance:COA
Boiling Point:85°C 4mm
Flash Point:283.1ºC
Water Solubility:18.4 [ug/mL]
Storage Conditions:Store at RT
Critical Temperature & Pressure:Store at RT
Hazard IdentificationClassification of the substance or mixture
Germ cell mutagenicity, Category 2
Carcinogenicity, Category 2
Reproductive toxicity, Category 2
Specific target organ toxicity â repeated exposure, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H341 Suspected of causing genetic defects
H351 Suspected of causing cancer
H361 Suspected of damaging fertility or the unborn child
H373 May cause damage to organs through prolonged or repeated exposure
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Response P318 IF exposed or concerned, get medical advice.
P319 Get medical help if you feel unwell.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Dichloromethane,Linocaine hydrochloride
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Location:
BUILDING 1,HISENSE INTELLIGENCE VALLEY,NO.2116,OF PHOEIX ROAD, HIGH-TECH ZONE ,JINAN CITY ,SHANDONG PROVINCE,CHINA
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Payment Terms:
D/P,L/C,D/A
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Average lead Time:
15
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Total Annual Revenue:
$10 million-$25 million
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Total Employees:
11-50
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Year of Establishment:
2016
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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