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Conivaptan hydrochloride

Conivaptan hydrochloride structure

CAS No:
168626-94-6
Formula:
C32H26N4O2.ClH
Chemical Name:
Conivaptan hydrochloride
Synonyms:
[1,1′-Biphenyl]-2-carboxamide,N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-,hydrochloride (1:1);[1,1′-Biphenyl]-2-carboxamide,N-[4-[(4,5-dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-,monohydrochloride;YM 087;Conivaptan hydrochloride;Vaprisol;conivaptan monohydrochloride
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

White to Off-White SolidChEBI: The hydrochloride salt of conivaptan. It is an antagonist for two of the three types of arginine vasopressin (AVP) receptors, V1a and V2, and is used for the treatment of hyponatraemia (low blood sodium levels) cau ed by syndrome of inappropriate antidiuretic hormone (SIADH).Arginine vasopressin is intimately involved in volume homeostasis, and elevated levels of arginine vasopressin are responsible for the pathogenesis and progression of diseases with an imbal

Conivaptan hydrochloride is the hydrochloride salt of conivaptan. It is an antagonist for two of the three types of arginine vasopressin (AVP) receptors, V1a and V2, and is used for the treatment of hyponatraemia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). It has a role as a vasopressin receptor antagonist. It contains a conivaptan.

Conivaptan hydrochloride Basic Attributes

Molecular Weight：

535.04

Exact Mass：

534.182251

EC Number：

1312995-182-4

UNII：

75L57R6X36

DSSTox ID：

DTXSID70168585

Characteristics

PSA：

78.1

XLogP3：

7.44730

Melting Point：

>250 °C

Boiling Point：

751.2°C at 760 mmHg

Flash Point：

408.1ºC

Vapor Pressure：

1.89E-22mmHg at 25°C

Drug Information

MeSH：

Endogenous compounds and drugs that inhibit or block the activity of ANTIDUIRETIC HORMONE RECEPTORS. (See all compounds classified as Antidiuretic Hormone Receptor Antagonists.)

MeSH Entry Terms：

(1,1'-biphenyl)-2-carboxamide, N-(4-((4,5-dihydro-2-methylimidazo(4,5-D)(1)benzazepin-6(1H)-yl)carbonyl)phenyl)-

Conivaptan hydrochloride Use and Manufacturing

Uses

Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin receptor antagonist).

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:535.0
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:534.1822538
Monoisotopic Mass:534.1822538
Topological Polar Surface Area:78.1
Heavy Atom Count:39
Complexity:820
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Recommended Suppliers of Conivaptan hydrochloride

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Conivaptan Hydrochloride API - A Dual Vasopressin Receptor Antagonist for Hyponatremia.

CAS No.: 168626-94-6

Grade: Pharmaceutical Grade

Content: 98.5%

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CN
5 YRS

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Conivaptan hydrochloride 99% see COA Kanbei kanbei

CAS No.: 168626-94-6

Grade: Industrial Grade

Content: 99%

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